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Found 27 clinical trials
Intensity Modulated Total Marrow Irradiation, Fludarabine Phosphate, and Melphalan in Treating Patients With Relapsed Hematologic Cancers Undergoing a Second Donor Stem Cell Transplant

This phase I trial studies the side effects and the best dose of intensity modulated total marrow irradiation (IMTMI) when given together with fludarabine phosphate and melphalan in treating patients with cancers of the blood (hematologic) that have returned after a period of improvement (relapsed) undergoing a second donor stem …

bone marrow transplant
lymphoid leukemia
myeloid leukemia
fludarabine
cell transplantation
  • 13 views
  • 25 Mar, 2022
  • 1 location
Liposome-encapsulated Daunorubicin-Cytarabine and Venetoclax in Treating Participants With Relapsed, Refractory or Untreated Acute Myeloid Leukemia

This phase II trial studies how well liposome-encapsulated daunorubicin-cytarabine and venetoclax work in treating participants with acute myeloid leukemia that has come back (relapsed), does not respond to treatment (refractory), or has not been treated (untreated). Drugs used in chemotherapy, such as liposome-encapsulated daunorubicin-cytarabine and venetoclax, work in different ways …

  • 3 views
  • 06 Jun, 2022
  • 1 location
Fludarabine in Combination With Daunorubicin and Cytarabine Liposome in Newly-diagnosed Acute Myeloid Leukemia.

This phase 2 clinical trial will evaluate the effectiveness and safety of fludarabine in combination with CPX-351 in patients with untreated AML. Patients will receive fludarabine and CPX-351 during Induction 1 and 2 as well as 2 cycles of consolidation therapy.

  • 0 views
  • 08 Apr, 2021
  • 1 location
Palliative Care Oncology in Patients With Relapsed, Refractory, and High-Risk Leukemias or MDS

The purpose of this study is to estimate the potential benefit of early and continued palliative care (PC) consultation on end of life issues.

  • 0 views
  • 12 May, 2022
  • 1 location
A Phase I Study of CYC140, a PLK-1 Inhibitor, in Advanced Leukemias or MDS

A Phase I Pharmacologic Study of CYC140, a polo-like kinase 1 inhibitor, in Patients with Advanced Leukemias or Myelodysplastic Syndromes

  • 0 views
  • 12 May, 2022
  • 1 location
NKX101, Intravenous Allogeneic CAR NK Cells, in Adults With AML or MDS

This is a single arm, open-label, multi-center, Phase 1 study to determine safety and tolerability of an experimental therapy called NKX101 (allogeneic CAR NK cells targeting NKG2D ligands) in patients with relapsed/refractory AML or intermediate, high and very high risk relapsed/refractory MDS

leukemia
white blood cell count
cancer
refractory acute myeloid leukemia (aml)
  • 0 views
  • 01 May, 2022
  • 7 locations
FT538 in Subjects With Advanced Hematologic Malignancies

This is a Phase I dose-finding study of FT538 as monotherapy in acute myeloid leukemia (AML) and in combination with monoclonal antibodies in multiple myeloma (MM). The study will consist of a dose-escalation stage and an expansion stage where participants will be enrolled into indication-specific cohorts.

leukemia
measurable disease
fludarabine
refractory acute myeloid leukemia (aml)
  • 0 views
  • 06 Jun, 2022
  • 9 locations
Ipilimumab and Decitabine in Treating Patients With Relapsed or Refractory Myelodysplastic Syndrome or Acute Myeloid Leukemia

This phase I trial studies the side effects and best dose of ipilimumab when given together with decitabine in treating patients with myelodysplastic syndrome or acute myeloid leukemia that has returned after a period of improvement (relapsed) or does not respond to treatment (refractory). Immunotherapy with monoclonal antibodies, such as …

blast cells
myeloid leukemia
myelodysplastic syndromes
gilbert's syndrome
remission
  • 235 views
  • 16 Jun, 2022
  • 3 locations
Nintedanib and Azacitidine in Treating Participants With HOX Gene Overexpression Relapsed or Refractory Acute Myeloid Leukemia

The purpose of this study is to find the appropriate dose of the study drug nintedanib when combined with azacitidine and the associated side effects of the combination in older adults with AML characterized by HOX gene overexpression who are not interested in or not considered fit for standard intensive …

human chorionic gonadotropin
hematologic malignancy
remission
azacitidine
myeloproliferative disorder
  • 2 views
  • 01 Feb, 2022
  • 1 location
Cladribine, Idarubicin, Cytarabine, and Venetoclax in Treating Patients With Acute Myeloid Leukemia, High-Risk Myelodysplastic Syndrome, or Blastic Phase Chronic Myeloid Leukemia

This phase II trial studies how well cladribine, idarubicin, cytarabine, and venetoclax work in patients with acute myeloid leukemia, high-risk myelodysplastic syndrome, or blastic phase chronic myeloid leukemia. Drugs used in chemotherapy, such as cladribine, idarubicin, cytarabine, and venetoclax, work in different ways to stop the growth of cancer cells, …

blast cells
myeloid leukemia
midostaurin
venetoclax
decitabine
  • 42 views
  • 17 Mar, 2022
  • 1 location