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Found 28 clinical trials
HDM201 and Midostaurin (HDMM) in Relapsed/Refractory AML With FLT3mut and TP53wt. (HDMM)

This is a non-randomized prospective open-label single-arm clinical phase I trial investigating dose finding, feasibility and safety of the combined treatment of HDM201 and midostaurin in patients with relapsed/refractory acute myeloid leukemia (AML) with FLT3mut applying an accelerated titration design.

  • 0 views
  • 24 Mar, 2022
  • 1 location
Selinexor With Combination With Induction/Consolidation Therapy in Acute Myeloid Leukemia Patients

This pilot phase II trial studies how well selinexor works when given together with induction, consolidation, and maintenance therapy in treating older patients with acute myeloid leukemia. Selinexor may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such …

  • 13 views
  • 13 May, 2022
  • 1 location
Microtransplantation Combined With Azacytidine to Improve the Efficacy of EAML

Patients enrolled from each center according to confirmed criteria specified in cooperative scheme are recieved induction and consolidation chemotherapy with microtransplantation . Observe the remission rate and 2-year disease-free survival (DFS) and overall survival(OS) rate.

  • 0 views
  • 13 Mar, 2022
  • 1 location
Study of MGTA-117 in Patients With Adult Acute Myeloid Leukemia (AML) and Myelodysplasia-Excess Blasts (MDS-EB)

This research study is designed to selectively deplete CD117-positive cells from participants with AML and MDS-EB.

leukemia
serum bilirubin level
blast cells
cancer
myeloid leukemia
  • 0 views
  • 10 May, 2022
  • 4 locations
Venetoclax + Decitabine vs. "7+3" Induction Chemotherapy in Young AML

This research is being done to assess the therapeutic efficacy and safety of a promising (venetoclax and decitabine) versus conventional "7+3"chemotherapy in induction young patients with acute myeloid leukemia. This study involves the following: Venetoclax and decitabine (investigational combination) Cytarabine and idarubicin (per standard of care)

  • 0 views
  • 13 Mar, 2022
  • 1 location
Organ-Sparing Marrow-Targeted Irradiation Before Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies

This pilot clinical trial aims to assess feasibility and tolerability of using an LINAC based "organ-sparing marrow-targeted irradiation" to condition patients with high-risk hematological malignancies who are otherwise ineligible to undergo myeloablative Total body irradiation (TBI)-based conditioning prior to allogeneic stem cell transplant. The target patient populations are those with …

methotrexate
stem cell transplantation
cyclophosphamide
anti-thymocyte globulin
tacrolimus
  • 27 views
  • 23 Mar, 2022
  • 1 location
Integrating Geriatric Assessment and Genetic Profiling to Personalize Therapy Selection in Older Adults With Acute Myeloid Leukemia

This phase II trial of the impact of clinicogenetic risk-stratified management on outcomes of acute myeloid leukemia in older patients is to determine the rate of complete remission and mortality at 90 days in the entire cohort of older patients (60 years) with newly diagnosed acute myeloid leukemia, who receive …

venetoclax
treatment related aml
idarubicin
cytarabine
daunorubicin
  • 8 views
  • 06 Aug, 2021
  • 2 locations
Phase 2, Open-Label, Single Arm Study, With BST-236 in Adults With R/R AML or Higher-Risk MDS

An open label multi center study to assess the safety and efficacy of BST-236 as single agent in adult patients unfit for standard therapy with Acute Myeloid Leukemia (AML) or higher-risk (HR) Myelodysplastic Syndromes (MDS) who fail to respond or relapsed following first line therapy. Approximately 20 adult patients with …

  • 0 views
  • 22 Mar, 2022
  • 4 locations
Precision Therapy Versus Standard Therapy in AML and MDS in Elderly

This is a randomized clinical trial that randomizes between treatment principles. The study will investigate if precision therapy determined by a tumour board is better than standard treatment for acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS) in elderly. The tumour board will decide the precision therapy based on identified …

azacitidine
hydroxyurea
leukemia
acute promyelocytic leukemia
  • 0 views
  • 03 Sep, 2021
  • 1 location
Intensity Modulated Total Marrow Irradiation, Fludarabine Phosphate, and Melphalan in Treating Patients With Relapsed Hematologic Cancers Undergoing a Second Donor Stem Cell Transplant

This phase I trial studies the side effects and the best dose of intensity modulated total marrow irradiation (IMTMI) when given together with fludarabine phosphate and melphalan in treating patients with cancers of the blood (hematologic) that have returned after a period of improvement (relapsed) undergoing a second donor stem …

mycophenolate mofetil
white blood cell count
stem cell transplantation
fludarabine
lymphoid leukemia
  • 13 views
  • 25 Mar, 2022
  • 1 location