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Found 30 clinical trials
Adrenalectomy Versus Follow-up in Patients With Subclinical Cushings Syndrome (AUSC)

Incidental findings of adrenal tumours,"incidentalomas", occur in 1-5 % in the general population and 10-25 % of these patients will exhibit biochemical mild hypercortisolism. Although the

  • 30 views
  • 24 Mar, 2022
  • 3 locations
SPI-62 as a Treatment for Hypercortisolism Related to a Benign Adrenal Tumor (ACSPIRE)

This will be a randomized, double-blind study to evaluate the efficacy, safety, and pharmacological effect of SPI-62 in subjects with hypercortisolism related to a benign adrenal tumor.

  • 0 views
  • 23 Jul, 2022
  • 1 location
Cryoablation of Bone Metastases From Endocrine Tumors

This study will evaluate the clinical response and safety of cone beam computed-tomography guided percutaneous cryoablation in bone metastases from thyroid, adrenal and neuroendocrine tumors in 30 patients.

bone metastases
metastasis
metastatic disease
adrenaline
neuroendocrine tumor
  • 19 views
  • 04 May, 2022
  • 1 location
B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)

3CAR is being done to investigate an immunotherapy for patients with solid tumors. It is a Phase I clinical trial evaluating the use of autologous T cells genetically engineered to express B7-H3-CARs for patients ≤ 21 years old, with relapsed/refractory B7-H3+ solid tumors. This study will evaluate the safety and …

fludarabine
ifosfamide
oximetry
solid tumor
pulse oximetry
  • 0 views
  • 25 Jul, 2022
  • 1 location
Anti-CTLA4-NF mAb (BMS986218), Nivolumab, and Stereotactic Body Radiation Therapy for the Treatment of Metastatic Solid Malignancies

This phase I/II trial studies the side effects of anti-CTLA4-NF monoclonal antibody (mAb) (BMS986218), nivolumab, and stereotactic body radiation therapy in treating patients with solid malignancies that has spread to other places in the body (metastatic). Immunotherapy with monoclonal antibodies, such as anti-CTLA4-NF mAb (BMS-986218) and nivolumab, may help the …

  • 0 views
  • 22 Mar, 2022
  • 1 location
Prospective Exploratory Study of FAPi PET/CT With Histopathology Validation in Patients With Various Cancers (FAPI PET RDRC)

This exploratory study investigates how an imaging technique called 68Ga-FAPi-46 PET/CT can determine where and to which degree the FAPI tracer (68Ga-FAPi-46) accumulates in normal and cancer tissues in patients with cancer. Because some cancers take up 68Ga-FAPi-46 it can be seen with PET. FAP stands for Fibroblast Activation Protein. …

thymus cancer
ct scan
cholangiocarcinoma
bladder tumor
pet scan
  • 0 views
  • 23 Jul, 2022
  • 1 location
Calcium Channel Blockade in Primary Aldosteronism

Primary aldosteronism is a common cause of hypertension. Recent evidence suggests that many patients with bilateral idiopathic hyperaldosteronism harbor gain-of-function somatic mutations in zona glomerulosa calcium channels that results in aldosterone production. This finding raises the possibility that calcium channel antagonists may be a targeted therapy to reduce aldosterone production …

amlodipine
hypertension
calcium channel
adrenal venous sampling
renin
  • 0 views
  • 16 Dec, 2021
  • 1 location
Precise Diagnosis, Treatment and Prognostic Evaluation of Complicated Adrenal Tumor Diseases

The adrenal gland is an important organ that produces life hormones. There are many types of adrenal tumors, which tend to occur in young adults and affect the whole body. It has the dual threat

  • 0 views
  • 08 Jan, 2022
  • 1 location
Structured Evaluation of adRENal Tumors Discovered Incidentally - Prospectively Investigating the Testing Yield

Standard diagnostic work-up for adrenal incidentalomas (AI) consists of periodical biochemical analysis and CT-scanning in case the initial work-up does not demonstrate the presence of hormonal hypersecretion or adrenocortical carcinoma (ACC), respectively. The overall aim of this study is to improve the cost-effectiveness of the diagnostic strategy for AI. Cost-effectiveness …

Accepts healthy volunteers
adrenal tumor
  • 11 views
  • 07 Oct, 2021
  • 1 location
Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks

Background The adrenal gland makes the hormone aldosterone. This helps regulate blood pressure. An adrenal gland tumor that makes too much aldosterone can cause

Accepts healthy volunteers
adrenal gland tumor
aldosterone
anesthesia
primary aldosteronism
  • 124 views
  • 25 Jul, 2022
  • 1 location