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Found 23 clinical trials
Multicenter Pheochromocytoma and Paraganglioma Evaluation

Target population: Patients with (1) newly diagnosed or (2) past history of pheochromocytomas and paragangliomas (PPGL) or (3) carrier of genetic mutations in known PPGL susceptibility genes. International multicenter prospective cohort study with randomized intervention (special care follow-up vs. standard care follow-up). All patients will receive instructions about follow-up at …

adrenal pheochromocytoma
paraganglioma
special care
pheochromocytoma
  • 36 views
  • 24 Jan, 2021
  • 1 location
Study to Evaluate Safety and Dosimetry of Lutathera in Adolescent Patients With GEP-NETs and PPGLs

This is a multicenter, open-label, single-arm study to evaluate the safety and dosimetry of Lutathera in adolescent patients 12 to <18 years old with somatostatin receptor positive GEP-NETs and PPGLs. The study will enroll at least 8 patients in the GEP-NET cohort and as many adolescents with PPGL as possible …

somatostatin
metastatic disease
dotatate
  • 0 views
  • 15 Jul, 2022
  • 11 locations
A Novel Therapeutic Vaccine (EO2401) in Metastatic Adrenocortical Carcinoma, or Malignant Pheochromocytoma/Paraganglioma

This is a multicenter, Phase 1/2, First-In-Human study to assess the safety, tolerability, immunogenicity, and preliminary efficacy of EO2401 in Metastatic Adrenocortical Carcinoma, or Malignant Pheochromocytoma/Paraganglioma.

adrenal pheochromocytoma
paraganglioma
therapeutic vaccine
pheochromocytoma
metastatic disease
  • 14 views
  • 17 Dec, 2021
  • 13 locations
Diagnosis of Pheochromocytoma

The goal of this study is to develop better methods of diagnosis, localization, and treatment for pheochromocytomas. These tumors, which usually arise from the adrenal glands, are often difficult to detect with current methods. Pheochromocytomas release chemicals called catecholamines, causing high blood pressure. Undetected, the tumors can lead to severe …

positron emission tomography
chromogranin a
iobenguane
clonidine
dopamine
  • 20 views
  • 28 Jul, 2022
  • 1 location
Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

This phase II trial studies nivolumab and ipilimumab in treating patients with rare tumors. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. This trial enrolls participants for …

leuprolide
gastrointestinal stromal tumor
parathyroid
hysterectomy
oophorectomy
  • 6634 views
  • 10 Aug, 2022
  • 752 locations
LAnreotide in Metastatic Pheochromocytoma / PARAganglioma (LAMPARA)

The objectives of this study are: To assess the efficacy of lanreotide given every 4 weeks in participants with advanced or metastatic paraganglioma/ pheochromocytoma. To assess the toxicity and safety of lanreotide in participants with advanced or metastatic paraganglioma/ pheochromocytoma. To document the effects of lanreotide on markers of biochemical …

adrenal pheochromocytoma
chromogranin a
pheochromocytoma
catecholamines
metastatic disease
  • 0 views
  • 24 Nov, 2021
  • 2 locations
Preoperative Alpha Blockade for Pheochromocytoma

Pheochromocytoma is a rare, catecholamine (ex. adrenaline) secreting tumor that requires preoperative alpha blockade to minimize intraoperative hemodynamic instability, thereby reducing intra- and postoperative morbidity and mortality. Phenoxybenzamine is a non-selective alpha blocker that is significantly more expensive and is associated with increased adverse effects in comparison with selective alpha …

adrenal pheochromocytoma
paraganglioma
phenoxybenzamine
adrenaline
catecholamines
  • 51 views
  • 24 Feb, 2022
  • 1 location
18F-Fluorodopamine PET Studies of Neuroblastoma and Pheochromocytoma

PET (positron emission tomography) scans combined with a radioactive tracer will be used to identify and analyze tumors. Currently, the most common tracer used to analyze neuroblastoma tumors is called 123I-mIBG. However, the picture it provides is not always clear enough to see the very small areas of the disease. …

positron emission tomography
adrenal pheochromocytoma
ct scan
positron emission tomography/computed tomography
iobenguane
  • 8 views
  • 24 Mar, 2022
  • 1 location
Study of Axitinib (AG-013736) With Evaluation of the VEGF-pathway in Pheochromocytoma/Paraganglioma

Primary Objective: To determine the response rate (RR) of metastatic or locally advanced pheochromocytoma/paraganglioma to axitinib administered daily. Secondary Objectives: Determine the progression-free survival. In an exploratory manner examine the extent of activation of the VEGFR pathway in pheochromocytoma/paraganglioma using a semi-quantitative immunohistochemistry assay and examine the relationship with response …

paraganglioma
ag-013736
iobenguane
measurable disease
dopamine
  • 1 views
  • 07 Feb, 2022
  • 1 location
Infrared Thermography Associated With Cutaneous Microcirculation for Detection of Brown-adipose Tissue (MICROBAT)

Patients affected by pheochromocytoma (PHEO) have brown-adipose tissue (BAT) hyperactivation. They perform, in routine settings, a FDG PET-CT scan. The high metabolic activity of BAT and its ability to consume both glucose and fatty acid suggest that it may have potential as a therapeutic target in the treatment of obesity. …

adrenal pheochromocytoma
ct scan
positron emission tomography/computed tomography
fdg pet/ct
18f-fdg
  • 0 views
  • 25 Jan, 2021
  • 1 location