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Found 15 clinical trials
Superenhancer Inhibitor Minnelide in Advanced Refractory Adenosquamous Carcinoma of the Pancreas (ASCP)

Background Pancreatic cancer is one of the most lethal types of cancer. ASCP is a highly aggressive type of pancreatic cancer. It is very rare. Researchers want to see if a drug called Minnelide can be used to treat ASCP. Objective To see if Minnelide is an effective treatment for …

  • 0 views
  • 15 Sep, 2021
  • 1 location
A Randomized Study of Olaparib or Placebo in Patients With Surgically Removed Pancreatic Cancer Who Have a BRCA1 BRCA2 or PALB2 Mutation The APOLLO Trial

This phase II trial investigates how well the addition of olaparib following completion of surgery and chemotherapy works in treating patients with pancreatic cancer that has been surgically removed (resected) and has a pathogenic mutation in BRCA1, BRCA2, or PALB2. Olaparib is an inhibitor of PARP, an enzyme that helps …

adenocarcinoma
carcinoma
palb2
cancer chemotherapy
BRCA1
  • 0 views
  • 15 Sep, 2021
  • 218 locations
Testing the Use of the Usual Chemotherapy Before and After Surgery for Removable Pancreatic Cancer

This phase III trial compares perioperative chemotherapy (given before and after surgery) versus adjuvant chemotherapy (given after surgery) for the treatment of pancreatic cancer that can be removed by surgery (removable/resectable). Chemotherapy drugs, such as fluorouracil, irinotecan, leucovorin, and oxaliplatin, work in different ways to stop the growth of tumor …

fluorouracil
leucovorin
cancer chemotherapy
calcium
pancreatic adenocarcinoma
  • 60 views
  • 26 Jan, 2021
  • 179 locations
Testing the Addition of a New Anti-Cancer Drug Triapine to the Usual Chemotherapy Treatment (Cisplatin) During Radiation Therapy for Advanced-stage Cervical and Vaginal Cancers

This randomized phase III trial studies radiation therapy and cisplatin with triapine to see how well they work compared to the standard radiation therapy and cisplatin alone in treating patients with newly diagnosed stage IB2, II, or IIIB-IVA cervical cancer or stage II-IVA vaginal cancer. Radiation therapy uses high energy …

cancer of the cervix
pet/ct scan
vaginal carcinoma
adenosquamous carcinoma
anticancer agents
  • 606 views
  • 15 Sep, 2021
  • 80 locations
Studying the Physical Function and Quality of Life Before and After Surgery in Patients With Stage I Cervical Cancer

This clinical trial studies the physical function and quality-of-life before and after surgery in patients with stage I cervical cancer. Studying quality-of-life in patients undergoing surgery for cervical cancer may help determine the intermediate-term and long-term effects of surgery.

adenocarcinoma
carcinoma
positron emission tomography
lymphadenectomy
metastasis
  • 842 views
  • 29 Jan, 2021
  • 54 locations
Radiation Therapy With or Without Chemotherapy in Patients With Stage I-IIA Cervical Cancer Who Previously Underwent Surgery

This randomized phase III trial studies radiation therapy with chemotherapy to see how well they work compared to radiation therapy alone in treating patients with stage I-IIA cervical cancer who previously underwent surgery. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as cisplatin, work …

adenocarcinoma
carcinoma
lymphadenectomy
absolute neutrophil count
adenosquamous carcinoma
  • 431 views
  • 01 Feb, 2021
  • 333 locations
Triapine With Chemotherapy and Radiation Therapy in Treating Patients With IB2-IVA Cervical or Vaginal Cancer

This phase I trial studies the side effects and best dose of triapine when given with radiation therapy and cisplatin in treating patients with stage IB2-IVA cervical or vaginal cancer. Triapine may stop the growth of cancer cells by blocking an enzyme needed for cell growth. Cisplatin is a drug …

adenosquamous carcinoma
pet/ct scan
external beam radiation therapy
x-rays
cervical carcinoma
  • 29 views
  • 15 Sep, 2021
  • 8 locations
Yoga Therapy During Chemotherapy and Radiation Treatment for the Improvement of Physical and Emotional Well-Being in Patients With Stage IB2-IIIB Cervical Cancer

This trial studies how well yoga therapy works during chemotherapy and radiation treatment in improving physical and emotional well-being in patients with stage IB2-IIIB cervical cancer. Yoga therapy may help to balance the mind and body through exercise, meditation (focusing thoughts), and control of breathing and emotions.

  • 0 views
  • 27 Jan, 2021
  • 1 location
Nab-Paclitaxel and Bevacizumab in Treating Patients With Unresectable Stage IV Melanoma or Gynecological Cancers

This phase I trial studies the side effects and best dose of nab-paclitaxel and bevacizumab in treating patients with stage IV melanoma that cannot be removed by surgery (unresectable), cancer of the cervix, endometrium, ovary, fallopian tube or peritoneal cavity. Drugs used in chemotherapy, such as nab-paclitaxel, work in different …

biomarker analysis
monoclonal antibodies
positron emission tomography
pet/ct scan
squamous cell carcinoma
  • 7 views
  • 08 Sep, 2021
  • 4 locations
Niraparib Combined With Brivanib or Toripalimab in Patients With Cervical Cancer

A Clinical Proof-of-concept Study Evaluating Efficacy and Safety of ZL-2306 (Niraparib) Combined With Brivanib or Toripalimab in Patients With Metastatic, Recurrent, and Persistent Cervical Cancer

adenocarcinoma
carcinoma
chemoradiotherapy
metastasis
adenosquamous carcinoma
  • 0 views
  • 29 May, 2021
  • 1 location