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Found 35 clinical trials
Evaluation of the Efficacy and Safety of Nal-IRI for Progressing Brain Metastases in Breast Cancer Patients (Phenomenal)

Multicenter open-label, phase II trial, to evaluate the efficacy and safety of nal-IRI in patients with HER2-negative breast cancer, who have documented Central Nervous System (CNS) progression following Whole Brain Radio Therapy (WBRT), Stereotactic Radiosurgery (SRS) and/or surgery, as determined by the Response Assessment in Neuro-Oncology Brain Metastases (RANO-BM) criteria.

neutrophil count
brain metastases
HER2
serum pregnancy test
taxane
  • 23 views
  • 19 Jun, 2022
  • 14 locations
Intraoperative Radiation Therapy (IORT) in DCIS

The goal of this study is to examine the role of Intraoperative Radiotherapy (IORT) in Ductal Carcinoma In-Situ (DCIS) and to improve the understanding of the clinical, radiographic, and patient-related impact of adopting IORT.

ductal carcinoma in situ
ductal carcinoma
intraoperative radiation therapy
mammogram
carcinoma in situ
  • 82 views
  • 01 Sep, 2021
  • 1 location
Pilot Study of a an App to Improve Medication Adherence in Breast Cancer Survivors Receiving AIs

The purpose of this study is to evaluate the feasibility of an mobile-health strategy to improve patient-reported symptoms, promote life-saving medication adherence, and encourage healthy lifestyle behaviors in early stage breast cancer survivors receiving adjuvant Aromatase inhibitors, while beginning to predict psycho-social and demographic characteristics of those who benefit most …

exemestane
ductal carcinoma in situ
pertuzumab
immunostimulant
aromatase inhibitor
  • 0 views
  • 22 Mar, 2022
  • 1 location
Real-Time MRI-Guided 3-Fraction Accelerated Partial Breast Irradiation in Early Breast Cancer (MAPBI)

This trial will investigate a novel 3-fraction radiation regimen for participants undergoing breast-conserving therapy (BCT) for early breast cancer that will: 1) significantly reduce the duration of treatment and can be completed in one-week (5 working days) and 2) MRI-guided radiotherapy (MRIdian) would limit the volume of normal tissue radiated …

ductal carcinoma in situ
carcinoma in situ
carcinoma
cancer
invasive carcinoma
  • 1 views
  • 26 May, 2022
  • 1 location
Study of 3-Day Partial Breast Radiation Therapy in Women With Breast Cancer

The purpose of this study is to determine if the dose of radiation therapy that is effective in producing a treatment response, delivered over a shorter treatment period, is a safe approach that causes few or mild side effects in women with newly diagnosed breast cancer or DCIS who have …

eosin
re-excision
immunohistochemistry
partial breast irradiation
lumpectomy
  • 0 views
  • 07 Apr, 2022
  • 9 locations
(VELA) Study of BLU-222 in Advanced Solid Tumors

This is a Phase 1/2, open-label, first-in-human (FIH) study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and anticancer activity of BLU-222, a selective inhibitor of CDK2.

ovarian cancer
cancer of the ovary
erbb2
cancer
HER2
  • 0 views
  • 16 Jun, 2022
  • 3 locations
Testing the Addition of an Anti-cancer Drug, Berzosertib, to the Usual Treatment (Radiation Therapy) for Chemotherapy-Resistant Triple-Negative and Estrogen and/or Progesterone Receptor Positive, HER2 Negative Breast Cancer

This phase Ib trial studies the best dose of berzosertib when given together with the usual treatment (radiation therapy) in treating patients with triple negative or estrogen receptor and/or progesterone receptor positive, HER-2 negative breast cancer. Berzosertib may stop the growth of tumor cells by blocking some of the enzymes …

adjuvant chemotherapy
re-excision
progesterone receptor
mastectomy
her2/neu-negative breast cancer
  • 0 views
  • 13 Jun, 2022
  • 5 locations
RAPA-201 Therapy of Solid Tumors

The therapy of solid tumors has been revolutionized by immune therapy, in particular, approaches that activate immune T cells in a polyclonal manner through blockade of checkpoint pathways such as PD-1 by administration of monoclonal antibodies. In this study, the investigators will evaluate the adoptive transfer of RAPA-201 cells, which …

paclitaxel
temsirolimus
lung cancer
targeted therapy
cancer chemotherapy
  • 0 views
  • 05 Jan, 2022
  • 1 location
A Study of PY314 in Subjects With Advanced Solid Tumors

This is an open-label, multicenter, first in human, Phase 1a/1b study of PY314 in subjects with locally advanced (unresectable) and/or metastatic solid tumors that are refractory or relapsed to standard of care (including pembrolizumab, if approved for that indication).

combination chemotherapy
core needle biopsy
lung cancer
cancer chemotherapy
platinum-based chemotherapy
  • 6 views
  • 27 Apr, 2022
  • 11 locations
PEN-866 in Patients With Advanced Solid Malignancies

Protocol PEN-866-001 is an open-label, multi-center, first-in-human Phase 1/2a study evaluating PEN-866 in patients with advanced solid malignancies whose disease has progressed after treatment with previous anticancer therapies.

bone marrow procedure
adjuvant chemotherapy
lung cancer
cancer chemotherapy
adenocarcinoma
  • 279 views
  • 23 Mar, 2022
  • 16 locations