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Found 201 clinical trials
Trial Evaluating the Tailored Versus the Systematic Use of Defunctioning Stoma After Total Mesorectal Excision for Rectal Cancer (GRECCAR17) (GRECCAR17)

GRECCAR 17 will be the first prospective and randomized trial to assess a tailored policy in the use of defunctioning stoma after TME according to the personalized risk of anastomotic leakage. The tailored use of defunctioning stoma after TME for rectal cancer should improve both the quality of life of …

renal function
metastasis
stoma closure
adenocarcinoma
total mesorectal excision
  • 0 views
  • 09 Jul, 2022
  • 4 locations
Transanal Irrigation for the Management of LARS (TAI-LARS)

This study aims to evaluate the impact of Transanal irrigation (TAI) on the quality of life and low anterior resection symptoms (LARS) in Canadian rectal cancer survivors living with minor to major LARS. It proposes to teach TAI through a novel online platform and to provide virtual nursing support for …

low anterior resection
total mesorectal excision
  • 0 views
  • 22 Mar, 2022
  • 1 location
A Phase II Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid Tumors

The purpose of this study is to find out whether the study drug, TSR-042, followed by standard chemoradiotherapy (the chemotherapy drug capecitabine + radiation therapy) and standard surgery is an effective treatment for advanced dMMR solid tumors. The study will also look at the safety of the study drug.

serum bilirubin
chemoradiotherapy
metastasis
adjuvant therapy
rectal carcinoma
  • 0 views
  • 24 Oct, 2022
  • 9 locations
Study of Cabozantinib and Nivolumab in Refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer

Data from a prior phase II study of single agent cabozantinib in metastatic, refractory colorectal cancer (NCT03542877) combined with the compelling preclinical data in colorectal mouse models utilizing cabozantinib combined with nivolumab have led to this concept for a clinical trial to combine cabozantinib and nivolumab in patients with metastatic …

monoclonal antibodies
VEGFR2
  • 0 views
  • 08 Dec, 2021
  • 5 locations
Efferent Loop Stimulation Previous to Ileostomy Closure. Ileostim Trial. (Ileostim)

The loop ileostomy is an effective method used to bypass faecal contents and reduce the sequelae of possible anastomotic leakage. I t is most often performed after a low anterior resection indicated for lower-middle rectal cancer. A second operation is required for closure, with a morbidity of about 25%. Many …

ileostomy closure
rectal anastomosis
cancer
postoperative ileus
cancer surgery
  • 0 views
  • 23 Apr, 2022
  • 1 location
A Phase II, Randomized, Open Label, Parallel-group Study of Atezolizumab With or Without Tiragolumab Following Neoadjuvant Chemoradiotherapy in Patients With Locally Advanced Rectal Cancer

This study will evaluate the efficacy and safety of atezolizumab plus tiragolumab or atezolizumab alone following neoadjuvant chemoradiotherapy (nCRT) in participants with locally advanced rectal cancer (LARC). The study consists of a safety run-in phase and a randomization phase. Participants enrolled in the safety run-in phase will receive atezolizumab + …

fluorouracil
chemoradiotherapy
adenocarcinoma
capecitabine
measurable disease
  • 0 views
  • 24 Oct, 2022
  • 1 location
Patients With Rectal Cancer: a "Wait-and-see" Approach

Patients with histologically proven adenocarcinoma of the rectum will receive pelvic radiotherapy to a dose of 45Gy in 25 fractions with a tumor boost to a dose of 9Gy in 5 fractions (thus total

metastasis
neutrophil count
adenocarcinoma
  • 8 views
  • 07 Oct, 2022
  • 4 locations
Organ Preservation Program Using Short-Course Radiation & FOLFOXIRI in Rectal Cancer

The purpose of the research is to evaluate whether both chemotherapy and radiotherapy can lead to higher rates of clinical complete response leading to organ preservation in human subjects with cancer. The objective is to learn if this treatment approach may safely be used as an alternative to the standard …

adenocarcinoma
irinotecan
oxaliplatin
fluorouracil
xelox
  • 7 views
  • 24 Mar, 2022
  • 1 location
Neo-adjuvant Pembrolizumab and Radiotherapy in Localised MSS Rectal Cancer

This project investigates the clinical and biological impact of combining immunotherapy (pembrolizumab) with short course radiotherapy (5Gy, five times) in the neo-adjuvant treatment of localised microsatellite stable (MSS) rectal cancer.

pembrolizumab
adenocarcinoma
adenocarcinoma of rectum
  • 0 views
  • 10 Oct, 2021
  • 1 location
Neoadjuvant Chemoradiotherapy With Sequential Ipilimumab and Nivolumab in Rectal Cancer (CHINOREC)

This prospective randomized, open-label, multicenter, phase II clinical trial investigates the safety and tolerability of standard neoadjuvant chemoradiotherapy (CRT) with sequential ipilimumab and nivolumab in rectal cancer.

chemoradiotherapy
carcinoma
capecitabine
  • 0 views
  • 19 Apr, 2022
  • 5 locations