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Found 201 clinical trials
A Phase II Study of Neoadjuvant Nivolumab Plus Ipilimumab and Short-Course Radiation in MSI-H/dMMR Locally Advanced Rectal Adenocarcinoma

This phase II trial investigates the effect of nivolumab and ipilimumab when given together with short-course radiation therapy in treating patients with rectal cancer that has spread to other places in the body (advanced). Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack …

  • 0 views
  • 21 Oct, 2022
  • 78 locations
Concordance in MRI and Pathology Diagnosis of Extranodal Tumour Deposits (COMET)

Predicting prognosis in rectal cancer and determining indications for neoadjuvant treatment is an ongoing challenge for colorectal multidisciplinary teams (MDTs). Staging is almost universally based on the TNM system which, despite multiple changes and increasing levels of sub-classification and complexity, is still flawed in its ability to stratify patients and …

cancer
adjuvant therapy
rectal carcinoma
  • 0 views
  • 30 Jan, 2022
  • 1 location
MRI-Guided Adaptive Radiation Therapy for Organ Preservation in Rectal Cancer

This study is a prospective, open-label, phase I design.

  • 0 views
  • 04 Oct, 2022
  • 1 location
Comparison Between Tailored Surgery Versus Total Mesorectal Excision in ycT2-3N0M0

The purpose of this study is to show that tailored treatment based on local excision can expand the target of non-radical treatment in ycT2-3N0M0 patients after neoadjuvant chemoradiotherapy for low rectal cancer and that the oncologic safety is not inferior to that of total mesorectal excision.

  • 0 views
  • 26 Mar, 2022
  • 1 location
Microbiome and Rectal Cancer

The purpose of our study is to determine if an association exists between the microbiome of those with rectal adenocarcinoma who are complete pathologic responders and those who have a partial

cancer
rectal carcinoma
adenocarcinoma of rectum
chemoradiotherapy
adenocarcinoma
  • 16 views
  • 28 Feb, 2022
  • 2 locations
Watch and Wait in PD-1 Monoclonal Antibody Treated dMMR/MSI-H Distal Rectal Cancer

Immunotherapy has achieved significant therapeutic effect in DNA mismatch repair-deficient or microsatellite instability-high (dMMR/MSI-H) colorectal cancer (CRC) , more than fifty percent of dMMR/MSI-H CRC patients might get pathological complete response(pCR) after PD-1 monoclonal antibody treatment. For distant rectal cancer(RC), radical resection and neoadjuvant chemotherapy or chemoradiotherapy might cause lots …

rectal surgery
obstruction
metastasis
transrectal ultrasound
chemoradiotherapy
  • 0 views
  • 23 May, 2021
  • 1 location
Total Neoadjuvant Therapy With mFOLFOX and Short-course Radiation in Resectable Rectal Cancer

This is phase 2 trial of neoadjuvant therapy and short-course radiotherapy in resectable rectal cancer.

renal function
leucovorin
adenocarcinoma
oxaliplatin
fluorouracil
  • 0 views
  • 25 Nov, 2021
  • 1 location
Computer Navigation-assisted Surgery for Locally Advanced and Recurrent Rectal Cancer

The aim of this study is to investigate feasibility of computer navigation-assisted surgery in particularly difficult cases of locally advanced (LARC) and recurrent (LRRC) rectal cancer where the standard surgical strategy is expected to result in incomplete tumour removal. The investigators hypothesize that computer navigation-assisted surgery can facilitate improved anatomic …

  • 0 views
  • 01 Jul, 2021
  • 1 location
Multicenter Study on Postoperative Urinary and Sexual Function During Laparoscopic Functional Total Mesorectum Excision

Urinary and sexual dysfunctions are among the most common complications in rectal cancer surgery. The aim of this study was to investigate the protective effect of laparoscopic functional total mesorectum excision (FTME) on urinary and sexual function in male patients with mid-low rectal cancer. This is a prospective, single-arm, multicenter, …

total mesorectal excision
  • 0 views
  • 08 Nov, 2021
  • 1 location
Magnetomotoric Ultrasound (MMUS) in Rectal Cancer

Magnetomotoric ultrasound, combines conventional ultrasound with a time-varying magnetic field. The aim is to improve diagnosis of mesolectal lymph nodes.

  • 0 views
  • 29 Sep, 2021
  • 1 location