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Found 202 clinical trials
Mechanical Bowel Preparation and Oral Antibiotics Versus Mechanical Bowel Preparation Only Prior Rectal Surgery

MOBILE2 is a randomized controlled trial comparing mechanical and oral antibiotic bowel preparation to mechanical bowel preparation only in patients undergoing anterior rectal resection with primary anastomosis. Primary endpoint is Comprehensive Complication Index within 30 days from surgery.

rectal surgery
antibiotic therapy
bowel preparation
antibiotics
proctectomy
  • 0 views
  • 14 Jun, 2021
  • 3 locations
Non Inferiority Study of Preoperative Chemotherapy Without Pelvic Irradiation for Rectal Cancer (NORAD01)

This study is a non-inferiority phase III randomised trial comparing preoperative chemotherapy alone (modified FOLFIRINOX) to chemotherapy followed by chemoradiotherapy in patients with primary resectable locally advanced rectal cancer. The primary endpoint of the study is 3-year progression free survival. Expected 3 year PFS rate in the preoperative chemotherapy followed …

irinotecan
capecitabine
chemoradiotherapy
oxaliplatin
transrectal ultrasound
  • 0 views
  • 01 Jul, 2022
  • 3 locations
Volatile Anaesthesia and Perioperative Outcomes Related to Cancer: The VAPOR-C Trial

VAPOR-C is a randomised study of the impact of IV versus inhaled anaesthesia (propofol versus sevoflurane) and lidocaine versus no lidocaine on duration of disease free survival inpatients with either colorectal or non small cell lung cancer.

lung carcinoma
  • 0 views
  • 07 Oct, 2022
  • 20 locations
Oncologic Outcomes of Single-incision Laparoscopic Surgery Versus Conventional Laparoscopic Surgery for Colorectal Cancer: A Multi-center, Prospective, Open Label, Non-inferiority, Randomized Controlled Trial (CSILS)

This study is designed to investigate long-term oncologic outcomes of single-incision laparoscopic surgery (SILS) compared to conventional laparoscopic surgery (CLS) for colorectal cancer.

carcinoma
  • 0 views
  • 28 Oct, 2022
  • 10 locations
Effectiveness and Implementation of mPATH-CRC

Study Investigators are conducting this study to learn how to best implement a new iPad program in clinical practice.

fecal immunochemical test
blood test
KIT
  • 35 views
  • 10 May, 2022
  • 1 location
Molecular Analysis for Therapy Choice (MATCH)

This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic …

erdafitinib
dabrafenib
metastatic disease
fgfr inhibitor azd4547
gonadotropin releasing hormone
  • 6595 views
  • 20 Oct, 2022
  • 906 locations
Fluorescence for Sentinel Lymph Node Identification in Cancer Surgery (GASVERT)

This is a single-center prospective clinical trial to evaluate non-inferiority of indocyanine green guided sentinel lymph node biopsy compared with the gold standard Technecium99 guided sentinel lymph node biopsy in patients with cancers and subjected to surgery. The diagnostic performance and the tolerance of indocyanine green (ICG) to the radio-isotope …

sentinel lymph node biopsy
sentinel node
indocyanine green
mammogram
cancer surgery
  • 34 views
  • 27 Apr, 2022
  • 1 location
Adaptive Radiation for Locally Advanced Rectal Adenocarcinoma

The purpose of the study is to determine the feasibility of using magnetic resonance imaging (MRI)-guided adaptive chemoradiation therapy to improve response to treatment.

  • 0 views
  • 04 Oct, 2022
  • 1 location
Treatment of Adenocarcinoma of the Rectum With Transanal Local Excision for Complete Responders

The current standard of care for rectal cancer has diminished local recurrence and enhanced survival. Quality of life, however, remains poor for many patients and the probability of distant recurrence is high. In this study, we will attempt to reduce the distant recurrence rate and improve quality of life by …

local excision
rectal surgery
adenocarcinoma
pelvic mri
adenocarcinoma of rectum
  • 0 views
  • 06 Feb, 2022
  • 1 location
Organ Preservation Strategy of Total Neoadjuvant Chemoradiotherapy for Early Low Rectal Carcinoma: A Prospective, Exploratory Trial (OP-TNT)

This study aims to evaluate the efficacy and safety of an organ-sparing strategy after neoadjuvant chemoradiotherapy followed by transanal endoscopic microsurgery (TEM) or endoscopic local resection for early low rectal cancer(cT 1-3N0M0).Besides, the clinical complete response rate and near-clinical complete response rate, organ preservation rate, local recurrence rate, distant metastasis …

capecitabine
metastasis
oxaliplatin
carcinoma
local excision
  • 0 views
  • 22 Oct, 2022
  • 1 location