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Found 116 clinical trials
Stereotactic Body Radiation Therapy or Intensity-Modulated Radiation Therapy in Treating Patients With Stage IIA-B Prostate Cancer

This randomized phase III trial studies how well stereotactic body radiation therapy works compared to intensity-modulated radiation therapy in treating patients with stage IIA-B prostate cancer. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Stereotactic body radiation therapy is a specialized radiation therapy that sends …

  • 934 views
  • 12 Jun, 2021
  • 179 locations
Therapeutic Effect of Cytoreductive Radical Prostatectomy in Men With Newly Diagnosed Metastatic Prostate Cancer

This randomized phase II trial studies how well surgical removal of the prostate and antiandrogen therapy with or without docetaxel work in treating men with newly diagnosed prostate cancer that has spread to other places in the body. Androgens can cause the growth of prostate cancer cells. Antiandrogen therapy may …

  • 22 views
  • 18 Apr, 2021
  • 15 locations
To Determine an Effective Dose of VERU-100 for the Treatment of Advanced Prostate Cancer

To determine an effective dose of VERU-100 for the treatment of advanced prostate cancer by assessing its effect on testosterone levels by Day 28 and maintenance through Day 91.

  • 0 views
  • 11 Jun, 2021
  • 7 locations
HDR vs LDR Brachytherapy as Monotherapy in the Treatment of Localized Prostate Cancer.

Investigators compare in a randomized clinical trial the results and side effects of high-dose- and low-dose-rate brachytherapy as monotherapy in the treatment of early, organ confined prostate cancer patients.

prostate specific antigen
cancer
brachytherapy
  • 18 views
  • 08 Nov, 2020
  • 1 location
Radium-223 in Biochemically Recurrent Prostate Cancer

Background Some men who have been treated for localized prostate cancer with surgery or radiation still show signs of the disease in their blood. This is called biochemically recurrent prostate cancer. Radium-223 is a small molecule. It uses radiation to kill cancer cells and improves survival in advanced prostate cancer. …

  • 0 views
  • 15 Jun, 2021
  • 1 location
A Phase I Gene Therapy Study of FP253/Fludarabine for Prostate Cancer

The primary objective of this study is to determine the safety and tolerability of a gene-directed enzyme prodrug therapy for prostate cancer. FP253 contains an ovine atadenovirus that expresses the E. coli enzyme purine nucleoside phosphorylase (PNP) under the control of a prostate-directed promoter. PNP converts systemically administered fludarabine (the …

adenocarcinoma of prostate
antiandrogen therapy
gonadorelin
adenocarcinoma
androgen suppression
  • 90 views
  • 07 Nov, 2020
  • 1 location
Prostate Adenocarcinoma TransCutaneous Hormones

RATIONALE: The increasingly prolonged and extended use of androgen deprivation therapy (ADT) in the treatment of prostate cancer, usually achieved through the administration of LHRH agonists, has raised concerns about long-term toxicities, in particular osteoporosis and adverse metabolic changes which may be associated with type II diabetes and increased cardiovascular …

antiandrogen therapy
diabetes
metastatic prostate cancer
adenocarcinoma
androgen suppression
  • 291 views
  • 27 Jan, 2021
  • 2 locations
Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Using PET/CT Imaging

This phase III trial compares the addition of apalutamide, with or without targeted radiation therapy, to standard of care treatment versus standard of care treatment alone in patients with prostate cancer biochemical recurrence (a rise in the blood level of prostate-specific antigen [PSA] after treatment with surgery or radiation). Diagnostic …

leuprolide
antiandrogen therapy
stereotactic body radiation therapy
bone scan
androgen suppression
  • 0 views
  • 15 Mar, 2021
  • 3 locations
A Phase III of Cabazitaxel and Pelvic Radiotherapy in Localized Prostate Cancer and High-risk Features of Relapse

The objective of this study is to assess the effect of neoadjuvant cabazitaxel and pelvic radiotherapy in combination with androgen deprivation therapy (ADT)-radiotherapy on clinical progression-free survival in patients with high-risk localized prostate cancer (with a stringent selection of patients with at least 2 high-risk features), in a 2 by …

neutrophil count
lymphadenectomy
cancer
antiandrogen therapy
androgen suppression
  • 0 views
  • 26 Jan, 2021
  • 1 location
Antiandrogen Therapy and Radiation Therapy With or Without Docetaxel in Treating Patients With Prostate Cancer That Has Been Removed by Surgery

This randomized phase II/III trial studies docetaxel, antiandrogen therapy, and radiation therapy to see how well it works compared with antiandrogen therapy and radiation therapy alone in treating patients with prostate cancer that has been removed by surgery. Androgen can cause the growth of prostate cells. Antihormone therapy may lessen …

  • 1468 views
  • 10 Jun, 2021
  • 329 locations