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Found 119 clinical trials
Stereotactic Body Radiation Therapy or Intensity-Modulated Radiation Therapy in Treating Patients With Stage IIA-B Prostate Cancer

This randomized phase III trial studies how well stereotactic body radiation therapy works compared to intensity-modulated radiation therapy in treating patients with stage IIA-B prostate cancer. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Stereotactic body radiation therapy is a specialized radiation therapy that sends …

  • 934 views
  • 17 Dec, 2020
  • 161 locations
Therapeutic Effect of Cytoreductive Radical Prostatectomy in Men With Newly Diagnosed Metastatic Prostate Cancer

This randomized phase II trial studies how well surgical removal of the prostate and antiandrogen therapy with or without docetaxel work in treating men with newly diagnosed prostate cancer that has spread to other places in the body. Androgens can cause the growth of prostate cancer cells. Antiandrogen therapy may …

  • 22 views
  • 08 Oct, 2020
  • 15 locations
NBTXR3 Nanoparticles and EBRT or EBRT With Brachytherapy in the Treatment of Prostate Adenocarcinoma

This study is a Phase 1/2 open-label involving 2 groups of patients newly diagnosed with either unfavorable intermediate risk or high risk prostate adenocarcinoma. One group will receive only

adenocarcinoma of prostate
androgens
external beam radiation therapy
pet/ct scan
neutrophil count
  • 0 views
  • 08 Nov, 2020
  • 1 location
68Ga-RM2 PET/MRI in Biochemically Recurrent Prostate Cancer

This phase II/III trial studies how well gallium (Ga) 68-labeled gastrin-releasing peptide receptor (GRPR) antagonist BAY86-7548 (68Ga-RM2) positron emission tomography (PET)/magnetic resonance imaging (MRI) works in detecting prostate cancer in patients with negative computed tomography (CT) scan and elevated prostate-specific antigen levels after treatment with surgery or radiation. PET/MRI scans …

tumor cells
prostate specific antigen
positron emission tomography
karnofsky performance status
MRI
  • 32 views
  • 24 Jun, 2019
  • 1 location
Prostate Radiotherapy Comparing Moderate and Extreme Hypo-fractionation (PRIME Trial)

Aim: The aim of the study is to compare the efficacy with SBRT and moderate hypo-fractionation in high risk and node positive prostate cancer PRIMARY STUDY OBJECTIVES: To assess whether extreme hypo-fractionation with SBRT in high risk prostate cancer is non inferior to moderately hypo-fractionated standard radiotherapy STUDY DESIGN: Two …

stereotactic body radiation therapy
orchiectomy
endocrine therapy
hormone therapy
cancer
  • 2 views
  • 27 Jan, 2020
  • 1 location
Perioperative Atezolizumab With MVA-BN-Brachyury and PROSTVAC For Intermediate-Risk And High-Risk Localized Prostate Cancer

This study is a prospective, open label, single arm phase II trial. A total of 22 patients will be treated with atezolizumab, PROSTVAC, and pre-operative MVA-BN-Brachyury to confirm the efficacy of prostatic combination immunotherapy and to measure the relative change in the number of tumor infiltrating CD8+ lymphocytes within the …

biopsy of prostate
platelet count
neutrophil count
prostatectomy
gilbert's syndrome
  • 4 views
  • 09 Sep, 2020
  • 1 location
Combination of Entinostat and Enzalutamide in Advanced Prostate Cancer

To determine the safety and tolerability of Entinostat in combination with Enzalutamide in metastatic castrate resistant prostate cancer

androgens
luteinizing hormone-releasing hormone agonist
androgen synthesis inhibitors
denosumab
testosterone
  • 4 views
  • 12 Aug, 2019
  • 1 location
Soy Bread Diet in Improving Immune Function in Participants With Prostate Cancer

This phase II trial studies the effects of a soy bread versus a wheat bread in improving immune function in participants who are beginning a course of androgen deprivation therapy for prostate cancer. Components found in soy foods may influence the immune system in a way that may be beneficial …

biopsy of prostate
pc-spes
testosterone
androgens
androgen suppression
  • 17 views
  • 11 Nov, 2020
  • 1 location
Prostate Cancer - Localized Adenocarcinoma Proton Therapy

A Phase II Randomized Trial of Hypofractionated Proton Therapy in Patients With A Localized Prostate Adenocarcinoma

cancer
  • 11 views
  • 08 Nov, 2020
  • 1 location
Hyperpolarized Pyruvate (13C) MR Imaging in Monitoring Patients With Prostate Cancer on Active Surveillance

This phase II trial studies the side how well hyperpolarized carbon C 13 pyruvate (HP C-13 pyruvate) magnetic resonance imaging (MRI) works in monitoring patients with prostate cancer on active surveillance who have not received treatment. Diagnostic procedures, such as MRI, may help visualize HP C-13 pyruvate uptake and breakdown …

tumor cells
cancer
multiparametric magnetic resonance imaging
neutrophil count
MRI
  • 0 views
  • 30 Jul, 2020
  • 1 location