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Found 34 clinical trials
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Metastatic Colorectal Cancer with wild-type KRAS tumors.

Metastatic Colorectal Cancer with wild-type KRAS tumors.

  • 204 views
  • 25 Mar, 2021
  • 1 location
Development of Clinical and Biological Database in Colorectal Cancer

Creation of circulating cancer cell-lines and caracterisation of these cell-lines which will be collected before any treatment in patients with metastatic colon adenocarcinoma

metastatic colorectal cancer
cancer
adenocarcinoma
  • 1 views
  • 26 Jan, 2021
  • 1 location
Randomised Study Evaluating Adjuvant Chemotherapy After Resection of Stage III Colonic Adenocarcinoma in Patients of 70 and Over

Colorectal cancer occurs mainly in elderly patients. Recent estimation showed that in France more than 50% of the patients diagnosed with a colorectal cancer are 70 years old or more. Adjuvant chemotherapy has demonstrated a benefit on disease-free survival and overall survival after a stage III colon cancer resection. Nevertheless …

stage iii colon cancer
colon cancer
primary tumor
fluoropyrimidine
oxaliplatin
  • 31 views
  • 24 Jan, 2021
  • 203 locations
Extended Peri-operative Tinzaparin to Improve Disease-free Survival in Patients With Resectable Colorectal Cancer

The human body has a natural stress response to surgery, including the formation of blood clots. This response to surgery has been shown to increase metastases (the spread of cancer cells to other organs in the body). These metastases cannot be seen at the time of surgery but when they …

metastasis
colon cancer
low molecular weight heparin
ct scan
cancer
  • 119 views
  • 24 Jan, 2021
  • 17 locations
Circulating Tumor DNA Testing in Predicting Treatment for Patients With Stage IIA Colon Cancer After Surgery

This phase II/III trial studies how well circulating tumor deoxyribonucleic acid (ctDNA) testing in the blood works in predicting treatment for patients with stage IIA colon cancer after surgery. ctDNA are circulating tumor cells that are shed by tumors into the blood. Finding ctDNA in the blood means that there …

absolute neutrophil count
leucovorin
calcium
oxaliplatin
capecitabine
  • 0 views
  • 23 Jan, 2021
  • 1 location
Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

This phase III trial studies combination chemotherapy and atezolizumab to see how well it works compared with combination chemotherapy alone in treating patients with stage III colon cancer and deficient deoxyribonucleic acid (DNA) mismatch repair. Drugs used in combination chemotherapy, such as oxaliplatin, leucovorin calcium, and fluorouracil, work in different …

stage iii colon cancer
hiv viral load
atezolizumab
absolute neutrophil count
monoclonal antibodies
  • 1047 views
  • 13 May, 2021
  • 575 locations
Assessing the Additional Neoplasia Yield of Computer-aided Colonoscopy in a Screening Setting

Even if colonoscopy is considered the reference standard for the detection of colonic neoplasia, polyps are still missed. The risk of early post-colonoscopy cancer appeared to be independently predicted by a relatively low polyp/adenoma detection rate. When considering the very high prevalence of advanced neoplasia in the FIT-positive enriched population, …

endoscopy
adenoma
cancer
  • 0 views
  • 24 Jan, 2021
  • 1 location
Tucatinib Plus Trastuzumab in Patients With HER2+ Colorectal Cancer

This trial studies how well the drug tucatinib works when given with trastuzumab and when given by itself. The participants in this trial have HER2-positive (HER2+) metastatic colorectal cancer (mCRC). 'Metastatic' means that the cancer has spread to other parts of the body. In the first part of this study, …

aflibercept
measurable disease
monoclonal antibodies
HER2
bevacizumab
  • 308 views
  • 09 May, 2021
  • 80 locations
The Pathogenesis of Chronic Diarrhoea After Treatment for Cancer in Cecum and the Ascending Colon

Many patients suffer from chronic diarrhoea after surgical treatment for cancer in the right side of the colon. The investigators' main hypothesis is that colon cancer patients with chronic diarrhoea have a higher risk of bile acid malabsorption compared with colon cancer patients without diarrhoea. The investigators also expect that …

cancer
antibiotic therapy
colon cancer
colesevelam
rifaximin
  • 1 views
  • 26 Jan, 2021
  • 1 location
MoLiMoR - A Study With FOLFIRI-based First-line Therapy With or Without Intermittent Cetuximab

This is an open-label, prospective, randomized, multicenter phase II trial that will evaluate the efficacy and safety of intermittent addition of cetuximab to a FOLFIRI-based first line therapy to patients with RAS (Rat sarcoma)-mutant mCRC (Metastatic colorectal cancer) diagnosis who convert to RAS wild-type using monitoring of the RAS mutation …

  • 0 views
  • 06 May, 2021
  • 20 locations