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Found 7 clinical trials
A Study to Assess the Effects of Itraconazole Rifampicin and Omeprazole on Pharmacokinetics of Adavosertib

This is a Phase 1, open-label, non-randomised, 3-arm (A, B, and C), drug-drug interaction study in patients with advanced solid tumours.

  • 0 views
  • 15 Sep, 2021
  • 6 locations
A Study of Adavosertib as Treatment for Uterine Serous Carcinoma

This Phase 2b study aims to evaluate the efficacy and safety of adavosertib, an inhibitor of the tyrosine kinase WEE1, in subjects with recurrent or persistent uterine serous carcinoma (USC) who

  • 1 views
  • 15 Sep, 2021
  • 50 locations
Adavosertib With or Without Olaparib in Treating Patients With Recurrent Ovarian Primary Peritoneal or Fallopian Tube Cancer

This phase II trial studies how well adavosertib with or without olaparib work in treating patients with ovarian, primary peritoneal, or fallopian tube cancer that has come back (recurrent

liver metastasis
fallopian tube
parp inhibitor
blood transfusion
direct bilirubin
  • 8 views
  • 24 Jan, 2021
  • 1 location
Testing AZD1775 in Advanced Solid Tumors That Have a Mutation Called SETD2

This phase II trial studies how well adavosertib works in treating patients with SETD2-deficient solid tumors that have spread to other places in the body (advanced/metastatic). Adavosertib may

liver metastasis
kinase inhibitor
direct bilirubin
tumor cells
measurable disease
  • 37 views
  • 15 Sep, 2021
  • 19 locations
Testing the Addition of an Anti-cancer Drug Adavosertib to Radiation Therapy for Patients With Incurable Esophageal and Gastroesophageal Junction Cancers

This phase I trial investigates the side effects and best dose of adavosertib and how well it works when given in combination with radiation therapy in treating patients with esophageal or

  • 0 views
  • 25 Aug, 2021
  • 5 locations
Testing the Sequential Combination of the Anti-cancer Drugs Olaparib Followed by Adavosertib (AZD1775) in Patients With Advanced Solid Tumors With Selected Mutations and PARP Resistance STAR Study

This phase I trial studies the side effects and best dose of adavosertib when given together with olaparib in treating patients with solid tumors that have spread to other places in the body

liver metastasis
palliative radiation therapy
parp inhibitor
nervous
oral contraception
  • 0 views
  • 24 Jun, 2021
  • 1 location
Adavosertib Before Surgery in Treating Patients With Advanced High Grade Ovarian Fallopian Tube or Primary Peritoneal Cancer

This pilot early phase I trial studies how adavosertib affects the tumor deoxyribonucleic acid (DNA) of patients undergoing surgery for high grade (fast growing or aggressive) ovarian, fallopian

fallopian tube
copper
tumor cells
absolute neutrophil count
azd1775
  • 0 views
  • 25 Jan, 2021
  • 9 locations