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Found 15 clinical trials
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30-Day Trial of Oral Valtrex or Valtrex Plus Aspirin on Shedding of HSV DNA in Tears and Saliva of Volunteers

The purpose of this study is to determine whether oral Valtrex alone or in combination with aspirin will reduce the shedding of herpes simplex virus DNA in the tears and saliva from volunteers with no evidence of ocular herpes infection. The secretion of virus into the tears and saliva might …

herpes simplex virus dna
valacyclovir
valtrex
herpes infection
heart disease
  • 1679 views
  • 07 Nov, 2020
  • 1 location
None
Do We Need to Taper Down Steroid Therapy for Bell's Palsy

Bell's palsy [BP] is defined as acute idiopathic peripheral facial palsy or paralysis. Additional symptoms frequently include pain around or behind the ear, impaired tolerance to ordinary levels of noise and disturbed sense of taste on the same side. It affects men and women more or less equally. There is …

  • 1 views
  • 24 Jan, 2021
  • 1 location
None
Effect of Lactobacillus Brevis CD2 in Prevention of Radio-chemotherapy Induced Oral Mucositis in Head and Neck Cancer

Oral mucositis is a debilitating side effect for oncology patients and there is a clear need for new therapeutic options. The lozenges containing Lactobacillus brevis CD2 proved a potential new alternative for the prevention of grade III and IV mucositis. The main endpoint of this study is to verify if …

cancer
neck cancer
head and neck cancer
concurrent chemotherapy
neutrophil count
  • 42 views
  • 08 Nov, 2020
  • 1 location
None
Trial on Efficacy and Safety of Pritelivir Tablets for Treatment of Acyclovir-resistant Mucocutaneous HSV (Herpes Simplex Virus) Infections in Immunocompromised Subjects

Randomized, open-label, multi-center, comparative trial to assess the efficacy and safety in immunocompromised subjects with acyclovir resistant or acyclovir susceptible mucocutaneous HSV

tingling
valacyclovir
vasectomy
copper
pritelivir
  • 15431 views
  • 19 Jan, 2022
  • 20 locations
None
Valacyclovir in Neonatal Herpes Simplex Virus Disease

of the standard of care treatment dose of intravenous acyclovir. 6 (up to 10 infants) with virologically confirmed neonatal herpes simplex virus (HSV) disease who meet all inclusion/exclusion

  • 0 views
  • 01 Oct, 2021
  • 1 location
None
Intratympanic Steroid for Bell's Palsy

Facial nerve paralysis is due to inflammation around the facial nerve. Current treatment for facial nerve paralysis is a 10 day course of oral steroids (which will reduce the inflammation), with electrodiagnostic testing. There have been limited studies on the use of intratympanic steroid injection, in addition to oral steroid, …

  • 21 views
  • 21 Apr, 2021
  • 1 location
None
Occlusion vs Standard Treatment for the Treatment of Herpes Zoster

This study evaluates the addition of occlusive dressings (hydrocolloids) or topical silicone gel in the treatment of shingles (herpes zoster). One third of the participants will receive a hydrocolloid occlusive dressing, one third will receive the topical silicone gel and one third will receive the current treatment of the rash …

calcium acetate
aluminum
rash
silicone gel
herpes
  • 184 views
  • 24 Jan, 2021
  • 2 locations
None
Combination of Pembrolizumab With TGR-1202 in Patients With Relapsed/Refractory CLL and B-cell NHL

This study will be a standard 3+3 design with a lead in of TGR-1202 at dose of 600mg (dose level 1) or 800mg daily (dose level 2) for 6 weeks, i.e. 2 cycles, followed by pembrolizumab at 200mg every 3 weeks for 8 cycles along with TGR-1202 for patients with …

chronic lymphocytic leukemia refractory
idelalisib
measurable disease
pembrolizumab
neutrophil count
  • 78 views
  • 16 Jan, 2022
  • 3 locations
None
Anti-Viral Clinical Trial for Alzheimer's Disease

Viruses may cause or contribute to the pathology of Alzheimer's disease. This research treatment study at the MEMORY DISORDERS CLINIC is the first ever clinical trial to address this hypothesis. This study includes: brain imaging, clinical assessments, anti-viral research treatment with pills.

mild cognitive impairment
mini-mental state examination
benzodiazepines
cholinesterase inhibitors
cognitive impairment
  • 0 views
  • 13 Oct, 2021
  • 2 locations
None
Anti-viral Therapy in Alzheimer's Disease

Anti-viral therapy in Alzheimer's disease will investigate the efficacy of treating patients with mild Alzheimer's disease with the U.S.A marketed generic anti-viral drug Valtrex (valacyclovir, 500mg oral tablet). Valacyclovir, titrated to 4 grams per day, repurposed to treat Alzheimer's disease, will be compared to matching placebo in the treatment of …

mild cognitive impairment
tau protein
mini-mental state examination
amyloidosis
benzodiazepines
  • 95 views
  • 19 Jan, 2022
  • 3 locations