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Found 411 clinical trials
Understanding Pain Perception in Osteoarthritis

Osteoarthritis (OA)is a painful and disabling disease, predicted to be the fourth largest cause of disability worldwide by 2020. It commonly affects the hip or knee ultimately resulting in total joint replacement. In order to assess disease progression and plan surgery, x-rays are taken as part of routine practice. However …

knee surgery
joint replacement
steroidal anti-inflammatory drugs
total knee replacement
osteoarthritis of knee
  • 26 Jan, 2021
  • 1 location
Evaluation of the Nociception Guided by NoL Index and PK of Fentanyl in Pediatric Patients Under General Anesthesia

Fentanyl is one of the most common used opioids for analgesia during general anesthesia, however there are few studies that describe the relationship between its pharmacokinetics and pharmacodynamics, especially in the pediatric population. The monitoring of the analgesia component during general anesthesia has been traditionally by changes in patient's vital …

  • 15 Mar, 2021
  • 1 location
Bio-significance of LPC16:0 in Fibromyalgia

Fibromyalgia (FM) is a very common but mysterious pain disorder characterized by chronic widespread muscular pain. Fatigue, anxiety and depression are common comorbidities. The syndrome is commonly associated with several symptoms, including fatigue, sleeping disturbance, cognitive impairment, and comorbid pain syndrome, especially irritable bowel symptoms and temporomandibular disease. Anxiety and …

  • 15 Apr, 2021
  • 1 location
Nociception-Level (NOL) for the Assessment of Pain in Patient Unable to Self-Report

In this study we aimed to investigate the performance and effectiveness of NOL and/or NOLedge as a tool for pain assessment in geriatric and critical ill non communicating patients. Our hypothesis was that NOL and the NOLedge may have good correlation with the health-care professional assessment PAINAD, BPS values, even …

cognitive assessment
pain assessment
  • 14 Jul, 2021
  • 1 location
Comparison of Receiving Painless Gastrointestinal Endoscopy in the Morning or Afternoon on Postoperative Sleep Quality

Gastrointestinal endoscopy (GIE) are important examinations for screening, diagnosing, and treating a variety of gastrointestinal diseases. Specifically, endoscopy is one of the best surveillance tools for early detection of several cancers, GIE is increasingly being used because of government support for cancer screening and growing interest in preventive medicine. But …

  • 16 May, 2021
  • 1 location
Multimodal Pain Treatment for Breast Cancer Surgery - a Prospective Cohort Study

) Postoperative pain is frequent in this population, with almost 50 % experiencing acute pain and 25-60 % subsequently live with chronic pain. (3-5) Today no golden standard for postoperative pain management

  • 15 May, 2021
  • 1 location
Neurotoxicity and Cardiotoxicity in Total Joint Arthroplasty

The purpose of this research is to understand whether patients who previously had total hip or total knee replacement experience memory, thinking or heart problems. This study will help us determine if and how often these problems occur.

joint arthroplasty
total knee replacement
aseptic loosening
joint reconstruction
repeat surgery
  • 27 Jan, 2021
  • 1 location
Postoperative Recovery and Comfort in Patients Undergoing Urologic Robotic Surgery

Previously published studies show that adding intrathecal morphine to general anesthesia can reduce the postoperative pain and length of stay (LOS) in varies types of surgery. A recent meta-analysis showed that the addition of intrathecal morphine at doses below 500g did not increase the risk of respiratory depression compared with …

  • 30 Jan, 2021
  • 1 location
AIMS Medical Outcomes Study

This epidemiologic research is being conducted as an observational prospective case series outcomes study of the use of advanced integrative specialty medical care and its effect on adult and pediatric patients with chronic or serious illnesses or mental health disorders.

  • 24 Jan, 2021
  • 1 location
Evaluation of ESMO Guidelines Applicability and Adherence in Cancer Pain Management in the Palliative Care Setting

Palliative care (PC) is focused on improving the Quality of Life (QoL) of patients living with a life-threatening illness. Each year, an estimated 40 million people need PC management in the world. In the European Union, it is estimated that about 4,5 million of people are in the need of …

palliative care
advanced cancer
cancer diagnosis
pain relieving
  • 28 Jun, 2021
  • 8 locations