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Found 407 clinical trials
Focused Ultrasound and RadioTHERapy for Noninvasive Palliative Pain Treatment in Patients With Bone Metastases

The FURTHER study aims to evaluate the effectiveness and cost-effectiveness of MR-HIFU (alone or in combination with EBRT) compared to EBRT alone, the standard-of-care, as a palliative treatment option to relieve CIBP. This multicenter, three-armed randomized controlled trial will be performed in six hospitals in four European countries, and will …

palliative care
bone metastases
hifu
focused ultrasound therapy
heat
  • 16 views
  • 24 Jan, 2021
  • 6 locations
Enhanced EHR-facilitated Cancer Symptom Control (E2C2) Pragmatic Clinical Trial

The Enhanced, EHR-facilitated Cancer Symptom Control (E2C2) pragmatic clinical trial will test the population-level implementation of validated approaches to detect and effectively manage sleep disturbance, pain, anxiety, depression, energy deficit/fatigue, and functional decline among patients with all types and stages of cancer using a cluster-randomized, stepped wedge design.

depressed mood
fatigue
anxiety
depression
sleep disturbances
  • 18 views
  • 22 Aug, 2021
  • 1 location
Effects of Partical Excavation in One Versus Two Procedures of Primary Deep Caries (PAPRICA)

Background: Deep caries is the most frequent reason for performing root canal treatments. Minimally invasive methods for the treatment of deep carious lesions might therefore be relevant to avoid pulp exposures and consequently to prevent root canal treatments. A 2 step carious removal approach has shown to avoid exposures. But …

  • 5 views
  • 26 Jan, 2021
  • 13 locations
Perineal Local Infiltration Study

The prevalence of birth canal lacerations is more than 70% of all deliveries in Canada. The repair of such lacerations is usually done using a pre-existing epidural analgesia. Once the analgesic effect of the epidural analgesia fades, the laceration may cause intolerable pain, and result in emotional stress, difficulties in …

  • 7 views
  • 08 Mar, 2021
  • 1 location
Ketamine for Acute Pain Management After Trauma

The purpose of this study is to compare the effectiveness of Ketamine drip along with usual care and usual care alone on trauma patients and to longitudinally quantify the pain experience of patients during hospitalization.

  • 0 views
  • 26 Jan, 2021
  • 1 location
Phase III Efficacy and Tolerability Trial of the Fixed Dose Combination of Etodolac 400 mg and Cyclobenzaprine 10 mg Versus Isolated Active Substances in Pain Control After Impacted Third Molar Extraction

This Phase III study will compare the efficacy and tolerability of a Fixed Dose Combination of Etodolac + Cyclobenzaprine versus the isolated drugs in postoperative pain control after impacted third molar extraction.

postoperative pain
analgesia
  • 0 views
  • 26 Jan, 2021
  • 1 location
Dose Finding Study of STR-324

This study aims to evaluate the analgesic effect and the safety of 4 doses of STR-324 administered as an infusion, with or without initial bolus, to patients suffering from post-operative pain. The sensitivity of the pain model used in the trial will be evaluated with a standard group treated with …

pain assessment
morphine
  • 1 views
  • 22 Jul, 2021
  • 1 location
Intrathecal Midazolam Fentanyl and Nalbuphine as Adjuvants to Bupivacaine in Spinal Anesthesia for Cesarean Section

The main limitations of spinal anesthesia are its short duration of action and do not provide prolonged postoperative analgesia when it is performed only with local anesthetics. Adding adjuvants drugs to intrathecal local anesthetics improves quality and duration of spinal blockade, and prolongs postoperative analgesia. It is also possible to …

analgesics
analgesia
anesthesia
bupivacaine
local anesthetics
  • 0 views
  • 18 Jul, 2021
  • 1 location
Comparison Between Pupillometry and the Numerical Rating Scale

Given the difficulties encountered with subjective pain assessment tools, one of the ideas for reducing the occurrence of insufficient analgesia administration in the emergency department is to find a tool capable of measuring pain without requiring the patient's participation, and which could be integrated into the systematic measurement of the …

pain assessment
analgesia
  • 0 views
  • 03 Sep, 2021
  • 1 location
Methoxyflurane Analgesia for Paediatric Injuries

This is a randomised, double-blind, multicentre, placebo controlled study to evaluate the safety and efficacy of methoxyflurane (Penthrox) for the treatment of acute pain in children and

penthrox
analgesia
methoxyflurane
pain in children
  • 7 views
  • 10 Sep, 2021
  • 10 locations