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Found 401 clinical trials
A Depression and Opioid Pragmatic Trial in Pharmacogenetics (DCRI Coordinating Center)

are the Acute Pain Trial, the Chronic Pain Trial, and the Depression Trial. Participants can enroll in only one of the three trials. Acute Pain Trial: A prospective, multicenter, two arm

headache
codeine
acute pain
depressed mood
fibromyalgia
  • 11 views
  • 10 Sep, 2021
  • 10 locations
Opioid Prescription After Cesarean Trial

Non-inferiority randomized trial of 5,500 women with a cesarean delivery randomized prior to discharge to either an individualized opioid prescription protocol (IOPP) that includes shared decision making or to a fixed opioid prescription of 20 tablets of oxycodone 5mg.

oxycodone
opioid
cesarean section
  • 100 views
  • 26 Jul, 2021
  • 10 locations
One vs Two Visits Root Canal Treatments in Infected Teeth

The primary aim of the study is to compare the outcome of one vs two visits endodontics (root canal treatments) performed in general dental practice of infected (necrotic) teeth, one and four years after treatment. Secondary aims are to compare the root filling quality and the frequency of complications for …

  • 0 views
  • 26 Feb, 2021
  • 4 locations
Effect of Low-dose Esketamine Combined With Target-controlled Infusion of Propofol for Painless Gastrointestinal Endoscopy

Purpose: 1. To determine the efficacy of low-dose esketamine in painless gastrointestinal endoscopy. 2. To determine the safety of low-dose esketamine in painless gastrointestinal endoscopy. 3. To provide a theoretical basis and new ideas for the application of esketamine as a new drug in perioperative period.

  • 0 views
  • 29 Jan, 2021
  • 1 location
Celiac Plexus Radio-Surgery for Pain Management

Many cancer patients, especially those with pancreatic cancer, suffer from severe lower back / upper abdominal pain. This pain is often poorly managed with standard treatments; the doses of painkiller required often induce side effects, whereas nerve block procedures (where a needle is deeply inserted into the back) are both …

pain relief
cancer chemotherapy
nerve block
celiac
trastuzumab
  • 21 views
  • 23 Jan, 2021
  • 7 locations
Pragmatic RCT of SBIRT-PM

Veterans seeking compensation for musculoskeletal (MSD) conditions often develop chronic pain and are at high risk for substance misuse. The Investigators propose to test the effectiveness and cost-effectiveness of Screening, Brief Intervention and Referral to Treatment for Pain Management (SBIRT-PM), designed to reduce pain and reduce risky substance use, in …

chronic pain
analgesia
pain relieving
  • 7 views
  • 30 Apr, 2021
  • 9 locations
An Innovative Tailored Intervention for Improving Children's Postoperative Recovery (WebTIPS)

The goal of this randomized trial is to examine the effectiveness of a tailored Internet-based Preparation Program (WebTIPS) in reducing anxiety and improving the recovery process in children undergoing surgery. Two hospitals and all parent-child dyads and healthcare providers (HCPs) will be randomized to either a Web-based Tailored Intervention Preparation …

delirium
anxiety
anesthesia
anxiety reduction
behavioral problems
  • 0 views
  • 04 Apr, 2021
  • 2 locations
Partial Breast Versus no Irradiation for Women With Early Breast Cancer

All early breast cancer patients are offered adjuvant breast radiation therapy (RT) after breast conserving surgery for an early breast cancer. Breast cancer is heterogeneous, and selected patients have a very low gain from RT, whilst they still have risk of acute and late side effects from RT. This trial …

cancer
breast cancer
  • 10 views
  • 25 Jan, 2021
  • 19 locations
Standard of Care Therapy With or Without Stereotactic Radiosurgery and/or Surgery in Treating Patients With Limited Metastatic Breast Cancer

This randomized phase II/III trial studies how well standard of care therapy with stereotactic radiosurgery and/or surgery works and compares it to standard of care therapy alone in treating patients with breast cancer that has spread to one or two locations in the body (limited metastatic) that are previously untreated. …

endocrine therapy
small intestine
ct scan
hormone therapy
biomarker analysis
  • 574 views
  • 09 Jun, 2021
  • 84 locations
Sociocultural & Biobehavioral Influences on Pain Expression and Assessment

Background People can feel different levels of pain. This may depend on social, cultural, and biological factors. These factors can also influence how people respond to each other, and how they judge other people s experiences. Researchers want to learn more about these relationships. Objective To study if social and …

pain assessment
heat
  • 64 views
  • 08 Aug, 2021
  • 1 location