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Found 247 clinical trials
Treatment of Newly Diagnosed High Risk Acute Lymphoblastic Leukemia in Children

Treatment of pediatric acute lymphoblastic leukemia (ALL) has advanced and the overall survival exceeds 80% nowadays. However the overall survival of high risk ALL remains 75-90%, thus recent

childhood all
white blood cell count
lymphoid leukemia
blood cell count
b-cell acute lymphoblastic leukemia
  • 8 views
  • 21 Jan, 2021
Vincristine Sulfate Liposome Injection (Marqibo®) in Combination With UK ALL R3 Induction Chemotherapy for Children, Adolescents, and Young Adults With Relapsed ALL

This is a pilot study utilizing Marqibo (vincristine sulfate liposome injection) combined with dexamethasone, mitoxantrone and asparaginase (UK ALL R3) for relapsed acute lymphoblastic leukemia

minimal residual disease
cytarabine
lymphoid leukemia
acute leukemia
lymphoma
  • 0 views
  • 27 Jan, 2022
  • 16 locations
Quality of Life in Pediatric Patients With Acute Lymphoblastic Leukemia Receiving Maintenance Chemotherapy

The purpose of the study is to evaluate the impact of exercise on physical activity levels and quality of life in children with acute lymphoblastic leukemia (ALL) receiving maintenance

  • 273 views
  • 09 Aug, 2021
  • 1 location
Ruxolitinib and Chemotherapy in Adolescents and Young Adults With Ph-like Acute Lymphoblastic Leukemia

This study will test if adding ruxolitinib to standard multi-drug chemotherapy regimen will be safe and tolerated in adolescents and young adults with newly diagnosed Ph-like acute lymphoblastic

cytarabine
cyclophosphamide
lymphoid leukemia
acute leukemia
methotrexate
  • 0 views
  • 27 Sep, 2021
  • 1 location
Effect of Fish Oil on Hyperlipidemia and Toxicities in Children and Young Adults With Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia (ALL) is the most common malignant disease among children. Treatment results have improved over time due to intensive risk-adapted therapy and the 5-year survival

asparaginase
dexamethasone
lymphoid leukemia
acute leukemia
pegaspargase
  • 1 views
  • 23 Jan, 2021
  • 4 locations
Study of the Infusion of ARI-0001 Cells in Patients With CD19 + Acute Lymphoid Leukemia Resistant or Refractory to Therapy (CART19-BE-02)

To assess the efficacy (in terms of response rate and duration) of the infusion of ARI-0001 cells (Adult differentiated autologous T-cells from peripheral blood, expanded and transducted with a lentivirus to express a chimeric antigen receptor with anti-CD19 specificity [A3B1] conjugated to the 4-aBB and CD3z co-stimulatory regions) in patients …

  • 0 views
  • 10 Aug, 2022
  • 6 locations
Acute Lymphoblastic Leukemia Therapies Informed by Genomic Analyses

adults with high-risk B and T cell precursor acute lymphoblastic leukemia (ALL). Using genomic and next generation DNA sequencing technologies, these investigators revealed that 14% of children with high

cytarabine
cancer
philadelphia chromosome
lymphoid leukemia
  • 7 views
  • 23 Feb, 2022
  • 1 location
A Triple-targeted Cell Preparation Targeting CD19/CD20/CD22 in Patients With Relapsed/Refractory B-cell Acute Lymphocytic Leukemia

A phase I, open-label clinical study to evaluate the safety, tolerability, and efficacy of LCAR-AIO, a triple-targeted cell preparation targeting CD19/CD20/CD22, in patients with relapsed/refractory B-cell acute lymphocytic leukemia

  • 0 views
  • 19 Jun, 2022
  • 2 locations
Augmentation of the Graft vs. Leukemia Effect Via Checkpoint Blockade With Pembrolizumab

This is a single arm, open-label, Phase 1b study of pembrolizumab for patients with myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), and acute lymphoblastic leukemia (ALL) whose

cancer
leukemia
myeloid leukemia
lymphoid leukemia
bone marrow procedure
  • 11 views
  • 23 Apr, 2022
  • 1 location
A Study of Blinatumomab in Patients With Pre B-cell ALL and B-cell NHL as Post-allo-HSCT Remission Maintenance

for patients with CD19+-B-cell malignancies (Acute Lymphoblastic Leukemia [ALL], Non-Hodgkin's Lymphoma [NHL]).

blinatumomab
white blood cell count
lymphoid leukemia
lymphocytic leukemia
lymphoma
  • 4 views
  • 08 Jun, 2022
  • 1 location