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Found 247 clinical trials
Bio-CAR-T BS Study

The aim of this Study is the evaluation of post-infusion CAR-T (Chimeric Antigen Receptor T Cell) expansion and persistence in patients with DLBCL, PMBCL and ALL undergoing CAR-T therapy; and the feasibility and efficacy of the treatment in the real life practice.

  • 24 May, 2022
  • 1 location
Assessment of Chimerism and Relapse Post Bone Marrow/Hematopoietic Cell Transplant (HCT) Using AlloHeme Test (ACROBAT)

AlloHeme is a chimerism test service that utilizes NGS technology to analyze SNP loci to quantify donor and recipient cells by measuring genomic DNA. Before transplant, patient and donor peripheral blood sample will be collected to identify informative marker for routine chimerism testing and baseline establishment for AlloHeme. Post-transplant blood …

myeloablative conditioning
  • 27 Jul, 2022
  • 5 locations
Muscle Dysfunction in Patients With Haematological Diseases

PURPOSE: To evaluate the prevalence and prognostic value of sarcopenia in patients diagnosed with hematological cancer diseases.

multiple myeloma
  • 17 Dec, 2021
  • 1 location
Healthy Bones, Healthy Life

Childhood cancer treatments are increasingly effective, leading to dramatic improvements in survival rates. These treatments often have devastating effects on the overall health of pediatric cancer survivors (PCS) since they occur during a critical time of bone growth, including increased risks of poor bone health, fracture, and diabetes. In normal …

hemoglobin a1c
vitamin d
insulin sensitivity
  • 21 Dec, 2021
  • 1 location
Collecting and Storing Tissue From Young Patients With Cancer

This laboratory study is collecting and storing tissue, blood, and bone marrow samples from young patients with cancer. Collecting and storing samples of tissue, blood, and bone marrow from patients with cancer to study in the laboratory may help doctors learn more about changes that may occur in DNA and …

brain tumor
ewing sarcoma/peripheral primitive neuroectodermal tumor
myeloid leukemia
lymphocytic leukemia
  • 14 Mar, 2022
  • 24 locations
Monitoring Minimal Residual Disease MRD in Pediatric B-acute Lymphoblastic Leukemia

This study aimed to investigate the performance of next-generation sequencing (NGS) techniques measuring immunoglobulin heavy chain (IgH)-variable, diversity, and joining (V[D]J) clonal rearrangements IgH-V[D]J NGS compared with flow cytometry (FCM) in detecting of minimal residual disease (MRD) for children with acute lymphoblastic leukemia treated with South Chinese Children Leukemia Group …

  • 04 Aug, 2021
  • 1 location
Development and Application of a Novel Digital Array PCR for Acute Myeloid Leukemia (AML)

Purpose: The purpose of this trial is to investigate whether a digital array assay can detect trace amounts of residual leukemia and predict relapse in acute myeloid leukemia (AML) patients in remission who have undergone allogeneic stem cell transplantation (SCT) at the North Carolina Cancer Hospital (NCCH). Participants: Adult patients …

cell transplantation
  • 29 Jun, 2022
  • 1 location