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Found 52 clinical trials
Featured trial
Nasal Spray for Migraines

A research study is evaluating an investigational nasal spray for the acute treatment of migraines.  

  • 23 Nov, 2020
  • 1 location
Breast Cancer Toxicity (CANTO)

The aims of the cohort will be to quantify impact of cancer treatments toxicities , and to generate predictors of chronic toxicity in patients with non-metastatic breast cancer. The project will include four specific aims : To develop a database of chronic treatment related toxicity in a cohort of 14750 …

Accepts healthy volunteers
  • 19 Apr, 2022
  • 1 location
Long-term Safety Study of Rimegepant in Pediatric Subjects for the Acute Treatment of Migraine

The purpose of this study is to test the long-term safety of rimegepant in the acute treatment of moderate or severe migraine in children and adolescents (≥ 6 to < 18 years of age).

  • 17 Sep, 2023
  • 105 locations
Intravenous Gammaglobulin for Sickle Cell Pain Crises

The purpose of this study is to determine whether intravenous immune globulin is safe and effective in the acute treatment of pain crises in sickle cell disease.

  • 07 Nov, 2020
  • 1 location
STORM: Safety, Feasibility, and Efficacy of Non-invasive Vagus Nerve Stimulation (nVNS) in the Treatment of Aneurysmal Subarachnoid Hemorrhage (STORM)

This is a single-site, single-arm, open-label pilot study assessing the safety, feasibility, and efficacy of non-invasive vagus nerve stimulation (nVNS), gammaCore, for the acute treatment of

  • 22 Oct, 2022
  • 1 location
Nerivio Device for Treatment of New Daily Headache Persistence (NDHP)

pain modulation (CPM) that activates a descending endogenous analgesic mechanism. Ultimately, the investigators hope to gain insights into the safety and efficacy of Nerivio™ for the acute treatment of

  • 12 Sep, 2023
  • 1 location
Transcutaneous Supraorbital Nerve Stimulator Versus Topiramate in Prevention of Recurrent Migraine

topiramate treatment is a typical effective method, while transcutaneous supraorbital nerve stimulation (SNS) was reported to be valuable for migraine acute treatment and even the prevention. As a new

  • 07 Oct, 2022
  • 1 location
Repeated Ketamine Infusions for Treatment-Resistant Bipolar Disorder: A Randomized, Double-blind, Midazolam-controlled, Phase II Clinical Trial (KET-BD)

, double-blinded, midazolam-controlled, two-week RCT evaluating the efficacy, safety and tolerability of four flexibly-dosed adjunctive ketamine infusions (0.5-0.75mg/kg infused over 40 minutes) for acute

  • 19 Oct, 2022
  • 1 location
Trial of Enhanced Neurostimulation for Anorexia (TRENA)

(rTMS) have clinical benefits for improving psychological and eating disorder related symptoms, which can persist at long-term follow ups after acute treatment (i.e., at 6 and 12 months). Here

  • 13 Aug, 2023
Efficacy of Nerve Blocks for Episodic Migraine

The purpose of this study is to see how well blocking two to ten of the scalp nerves (that give feeling to the scalp and are painful during migraine headaches) with bupivacaine anesthetic (numbing medication) and low dose methylprednisolone (cortisone-like medicine or steroid) work for treating and preventing migraines. Our …

  • 30 Jul, 2023
  • 1 location