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Found 37 clinical trials
Short-term Survival of Subjects With Acute-on-chronic Liver Failure After Plasma Exchange With Human Serum Albumin 5%

This is a Phase 3, multicenter, randomized, controlled, parallel-group, open-label study to evaluate the effects of plasma exchange using human serum albumin 5% (PE-A 5%) in acute-on-chronic

plasma exchange
  • 35 views
  • 30 Sep, 2021
  • 45 locations
Effects of Long-Term Administration of Human Albumin in Subjects With Decompensated Cirrhosis and Ascites

with ascites (or with prior history of ascites requiring diuretic therapy) with or without acute-on-chronic liver failure (ACLF) at admission or during hospitalization but without ACLF at discharge.

  • 22 views
  • 25 Jul, 2021
  • 66 locations
Platelet Transfusion in Acute-on Chronic Liver Failure

Acute on-chronic liver failure (ACLF) is a severe liver disease with a 28-day mortality rate of up to 40%. When the patients get 3 or more organ failures, the 28-day mortality rate is up to 82.6

  • 0 views
  • 26 Jan, 2021
  • 8 locations
Study to Evaluate the Efficacy and Safety of HepaStem in Patients With Acute on Chronic Liver Failure (ACLF)

This is an interventional, double blind, randomized (2:1), and placebo-controlled study of 1 dose regimen of HepaStem in patients recently diagnosed (1 week) with ACLF grade 1 or 2 on top of Standard of Care (SoC), and for whom the diagnosis is not resolved on the day of infusion.

dose regimen
  • 0 views
  • 09 Jan, 2022
  • 8 locations
Mesenchymal Stem Cells Treatment for Decompensated Liver Cirrhosis

Decompensated liver cirrhosis is a life-threatening chronic liver disease with high mortality. Liver transplantation is the only option that can improve the survival of these patients; however, this procedure is associated with several limitations, such as the severe shortage of donor livers, long waiting lists, multiple complications, and high cost. …

  • 37 views
  • 23 Jan, 2021
  • 1 location
Anti-fungal Strategies in Acute-on-Chronic Liver Failure Patients

Early treatment of invasive fungal infections (IFI) may prevent undue mortality in acute on chronic liver failure (ACLF) patients. We aim to study the impact of early empiric treatment (based on

abdominal perforation
invasive fungal infections
pulmonary diseases
ascites
COPD
  • 0 views
  • 21 Mar, 2021
  • 1 location
Cytokine Adsorption in Acute-on-chronic Liver Failure

patients with acute-on-chronic liver failure. The primary goal for this trial is to assess whether the CytoSorb device used in addition to continuous renal replacement therapy (CRRT) will be able to

renal replacement therapy
  • 0 views
  • 11 Nov, 2021
  • 1 location
Study to Evaluate Safety and Efficacy of LifeLiver in Acute or Acute-on-Chronic Liver Failure Patients

approximately 40 acute or acute-on-chronic liver failure patients.

international normalized ratio
hepatic failure
liver transplant
encephalopathy
chronic liver failure
  • 4 views
  • 24 Jan, 2021
  • 1 location
Combination of DPMAS and Low Volume PE for Patients With HBV Related ACLF

exchange in patients with hepatitis b virus related acute-on-chronic liver failure.

  • 0 views
  • 28 Oct, 2021
  • 1 location
Three Types of Nucleotide/Nucleoside Analogues Treatment in HBV Related ACLF

This study is to investigate the clinical efficacy of three types of nucleotide/nucleoside analogues in treatment of HBV-related acute-on-chronic liver failure.

hepatitis b antigen
tenofovir
hepatic failure
entecavir
prothrombin
  • 3 views
  • 23 Jan, 2021
  • 1 location