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Found 367 clinical trials
Multi-centre Prospective Cohort of Childhood Leukaemia: Determinants of Health and Quality of Life of the Patients After Treatment for an Acute Leukaemia During Childhood or Adolescence - LEA

Regular advances in cancer treatment have dramatically improved the prognosis of children and adolescents with acute leukemia (AL), raising with a great acuity the problem of the late physical

  • 0 views
  • 21 Jan, 2021
  • 1 location
Intermittent Liposomal Amphotericin B Primary Prophylaxis

The purpose of this trial is to see which dose of liposomal amphotericin B is the safest when used as a preventer against invasive fungal infection in patients with acute leukaemia who

acute leukemia
  • 16 views
  • 07 Nov, 2020
  • 1 location
Microcirculation in Patients With Leukemic Hyperleukocytosis

Hyperleukocytosis in patients with acute leukemia impacts rheology and microvascularization, leading to severe symptoms or even death. The investigators investigated whether blood stream

  • 0 views
  • 24 Jan, 2021
  • 1 location
Risk Stratification-directed NAC for Prevention of Poor Hematopoietic Reconstitution

incidence of poor hematopoietic reconstitution after allo-HSCT in patients with ECs <0.1% pre-HSCT. Therefore, the investigators designed the study with acute leukemia patients who will be

cell transplantation
n-acetylcysteine
acute leukemia
remission
  • 0 views
  • 26 Jan, 2021
  • 1 location
The Role of Ruxolitinib in Secondary Acute Myelogenous Leukemia Evolving From Myeloproliferative Neoplasm

This trial aimed to investigate the therapeutic efficacy of ruxolitinib in combination with cytotoxic chemotherapy for post-myeloproliferative neoplasm secondary acute myeloid leukemia.

  • 1 views
  • 24 Jan, 2021
  • 2 locations
Different Therapies in Treating Infants With Newly Diagnosed Acute Leukemia

from happening. It is not yet known which treatment regimen is most effective in treating acute leukemia. PURPOSE: This randomized clinical trial is studying how well different therapies work in

busulfan
filgrastim
prednisone
cytarabine
asparaginase
  • 12 views
  • 23 Jan, 2021
  • 5 locations
Matched Unrelated vs. Haploidentical Donor for Allogeneic Stem Cell Transplantation in Patients With Acute Leukemia

Primary objective of this open label, two-arm, multicenter, multinational, randomized trial is to compare anti-leukemic activity of allogeneic stem cell transplantation for patients with acute

cyclophosphamide
acute leukemia
cell transplantation
leukemia
remission
  • 1 views
  • 03 May, 2021
  • 24 locations
A Study to Evaluate the Efficacy and Safety of Daratumumab in Pediatric and Young Adult Participants Greater Than or Equal to (>=)1 and Less Than or Equal to (<=) 30 Years of Age With Relapsed/Refractory Precursor B-cell or T-cell Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

The purpose of this study is to evaluate the efficacy of daratumumab in addition to standard chemotherapy in pediatric participants with relapsed/refractory B-cell acute lymphoblastic leukemia (ALL)/lymphoblastic lymphoma (LL) and T-cell ALL/LL as measured by the complete response (CR) rate.

vincristine
prednisone
cytarabine
asparaginase
methotrexate
  • 112 views
  • 04 Feb, 2021
  • 74 locations
Treatment Protocol for Children and Adolescents With Acute Lymphoblastic Leukemia - AIEOP-BFM ALL 2017

The understanding of acute lymphoblastic leukemia (ALL) in childhood and adolescence has largely changed due to extensive genetic research in recent years: ALL is now considered to be a very heterogeneous disease group. The leukemia cells present themselves with quite differently activated regulatory mechanisms of the malignant phenotype. The introduction …

cytarabine
daunorubicin
methotrexate
etoposide
pegaspargase
  • 562 views
  • 26 Jan, 2021
  • 168 locations
Childhood Acute Lymphoblastic Leukemia Treatment Protocol Moscow-Berlin 2015 (ALL-MB 2015)

QUESTIONS AND OBJECTIVES OF ALL-MB 2015 STUDY Will the new risk group stratification (especially of T-ALL) to improve overall and event-free survival? Will the new protocol is effective and feasible in patients older than 15 years, and especially in young adults? Whether the intermittent dexamethasone administration in induction will result …

dexamethasone
daunorubicin
adult t-cell leukemia/lymphoma
childhood all
lymphoid leukemia
  • 161 views
  • 23 Jan, 2021
  • 59 locations