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Found 134 clinical trials
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GRAVITAS-301: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of Itacitinib or Placebo in Combination With Corticosteroids for the Treatment of First-Line Acute Graft-Versus-Host Disease

GRAVITAS-301: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of Itacitinib or Placebo in Combination With Corticosteroids for the Treatment of First-Line Acute Graft-Versus-Host

graft-versus-host disease
  • 1462 views
  • 08 Dec, 2020
  • 11 locations
featured
A Single-Cohort, Phase 2 Study of Ruxolitinib in Combination With Corticosteroids for the Treatment of Steroid-Refractory Acute Graft Versus-Host Disease

A Single-Cohort, Phase 2 Study of Ruxolitinib in Combination With Corticosteroids for the Treatment of Steroid-Refractory Acute Graft Versus-Host Disease

bone marrow transplant
stem cell transplant
stem cell transplantation
transplant conditioning
nutritional supplement
  • 300 views
  • 08 Dec, 2020
  • 1 location
featured
Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease

Background: Peripheral blood stem cell transplantation procedures are used for people with sickle cell disease. Researchers want to improve the success and reduce the complications for these procedures. This might allow more people to have a transplant. Objective: To see if a new transplant regime is effective, safe and well …

red blood cell disorder
stroke
cell transplantation
sickle cell disease
  • 57 views
  • 22 Dec, 2020
  • 1 location
Vedolizumab in the Prophylaxis of Intestinal Acute Graft Versus Host Disease (aGVHD) in Participants Undergoing Allogeneic Hematopoietic Stem Cell (Allo-HSCT) Transplantation

The purpose of this study is to evaluate the efficacy of vedolizumab when added to background aGvHD prophylaxis regimen compared to placebo and background aGvHD prophylaxis regimen on intestinal

  • 42 views
  • 26 Jan, 2021
  • 113 locations
Fecal Microbiota Transplantation in aGvHD After ASCT

Acute graft-versus-host-disease (aGvHD) is a typical complication after allogeneic hematopoetic stem cell transplantation (ASCT). About 30-60% of patients after ASCT are affected by aGvHD, which

  • 0 views
  • 25 Jan, 2021
  • 1 location
MSCs Combined With CD25 Monoclonal Antibody and Calcineurin Inhibitors for Treatment of Steroid-resistant aGVHD

-resistant acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation.

calcineurin inhibitor
cell transplantation
monoclonal antibody
  • 0 views
  • 07 Nov, 2020
  • 1 location
Neihulizumab (AbGn-168H) in Patients With Steroid-refractory Acute Graft-versus-host Disease

A Phase I study to establish the pharmacokinetics, pharmacodynamics, safety and efficacy profiles of Neihulizumab in patients with steroid-refractory acute graft-versus-host disease(sr-aGvHD)

  • 32 views
  • 28 Jan, 2021
  • 17 locations
Individualized Dose Study of ATG in Haploidentical Hematopoietic Stem Cell Transplantation

The purpose of this study is to determine the response and toxicity rate of two different dosages (Individualized dosage VS. fixed dosage) of ATG as a prophylaxis for acute GVHD in

  • 0 views
  • 12 Mar, 2021
  • 1 location
Trial of Filgrastim Versus Placebo Following Allogeneic Bone Marrow Transplantation

study is to determine the effect of granulocyte colony-stimulating factor [G-CSF] (Neupogen; filgrastim) on the risk of acute GvHD after allogeneic bone marrow transplantation.

myeloablative conditioning
granulocyte colony stimulating factor
transplant conditioning
anemia
bone marrow transplant
  • 47 views
  • 07 Nov, 2020
  • 1 location
Hyperbaric Oxygen Therapy for Hemorrhagic Cystitis Post HSCT

bladder is also considered to be one of the immune attacked organs in acute graft-versus-host disease (aGVHD). The classic treatments for HC include hydration, alkalization, and bladder irrigation

clot formation
tissue damage
graft versus host disease
hemorrhagic cystitis
cell transplantation
  • 0 views
  • 24 Jan, 2021
  • 1 location