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Found 10 clinical trials
Dihydroartemisinin-Piperaquine or Sulphadoxine-Pyrimethamine for the Chemoprevention of Malaria in Sickle Cell Anaemia

Sickle Cell Anaemia (SCA) is an inherited disease that makes the body produce red blood cells with abnormal sickle-shaped cells. The sickle-shaped cells are rigid, not flexible and break up easily resulting in anaemia. The abnormal cells also stick to the vessel walls, causing a blockage that slows or stops …

  • 0 views
  • 18 Aug, 2021
  • 3 locations
Defibrotide in Sickle Cell Disease-Related Acute Chest Syndrome

This study evaluates the safety of defibrotide in subjects with sickle cell disease (SCD)-associated acute chest syndrome (ACS).

dyspnea
thalassemia
sickle hemoglobin
cough
acute chest syndrome
  • 1 views
  • 26 Feb, 2022
  • 1 location
Daily Vitamin D for Sickle-cell Respiratory Complications (ViDAS-2)

This study aims to answer the question whether daily oral vitamin D supplementation can reduce the risk of respiratory or lung complications in children and adolescents with sickle cell disease. Respiratory problems are the leading causes of sickness and of death in sickle cell disease. The investigators hypothesize that daily …

cholecalciferol
vitamin d supplementation
thalassemia
sickle hemoglobin
haemoglobin
  • 1 views
  • 15 Jul, 2022
  • 1 location
Imatinib for Pain in Sickle Cell Anemia (IMPACT)

, and possibly acute chest syndrome and utilization of opioids. The study duration is planned as 6 months in order to provide adequate time for potential change in the primary endpoints (e.g. percent

opioid
Accepts healthy volunteers
thalassemia
acute chest syndrome
electrophoresis
  • 0 views
  • 11 Aug, 2022
  • 2 locations
Sickle Cell Disease and CardiovAscular Risk - Red Cell Exchange Trial (SCD-CARRE) (SCD-CARRE)

The SCD-CARRE trial is a Phase 3, prospective, randomized, multicenter, controlled, parallel two-arm study aimed to determine if automated exchange blood transfusion and standard of care administered to high mortality risk adult SCD patients reduces the total number of episodes of clinical worsening of SCD requiring acute health care encounters …

blood transfusion
thalassemia
sickle hemoglobin
hemoglobin s
exchange transfusion
  • 24 views
  • 26 May, 2022
  • 17 locations
Cutaneous Hydration Assessment in SCD

This study will validate the diagnostic accuracy of a cutaneous hydration sensor. This sensor will also be evaluated for its feasibility as a point-of-care device for the assessment of hydration status and its potential to guide hydration therapy in patients with sickle cell disease (SCD).

thalassemia
  • 0 views
  • 26 Apr, 2022
Qualitative Survey of Potential Exercise Activity in Adults With Sickle Cell Anemia (SCA) (SCA)

The purpose of this study is to assess the potential interventions of exercises in adults with sickle cell anemia (SCA) and cardiopulmonary disease; only including the more severe genotypes of sickle cell disease.

anemia
  • 6 views
  • 26 Jan, 2022
  • 1 location
Primary Prevention of Stroke in Children With Sickle Cell Anaemia in Nigeria in the Community (SPRING-COM)

The overall goal of this feasibility study is to establish a standard of care stroke prevention program for children with sickle cell anemia in a community hospital by task shifting stroke detection and transcranial Doppler ultrasound screening to nurses. In Nigeria, approximately 150,000 children with sickle cell anemia (SCA) are …

stroke
blood transfusion
hydroxyurea
  • 0 views
  • 15 Jul, 2022
  • 1 location
Low Dose Aspirin for Preventing Intrauterine Growth Restriction and Preeclampsia in Sickle Cell Pregnancy (PIPSICKLE) (PIPSICKLE)

Pregnancy in sickle cell disease (SCD) is fraught with many complications including preeclampsia (PE) and intrauterine growth restriction (IUGR). Previously, the investigators found an abnormality in prostacyclin-thromboxane ratio in sickle cell pregnant women, a situation that is also found in non-sickle pregnancies with PE and unexplained IUGR. Low dose aspirin …

fetal growth retardation
Accepts healthy volunteers
vasoconstrictor
aspirin
  • 0 views
  • 05 Mar, 2022
  • 13 locations
Sickle Cell Disease Obstetric Multi-Disciplinary Care Programme (SCOB-II)

for decreasing mortality across three hospital sites in Ghana. 2) assess the implementation fidelity for 2a) preventing and 2b) treating acute chest syndrome in pregnant women with SCD admitted to the

chest syndrome
acute chest syndrome
electrophoresis
  • 0 views
  • 02 May, 2022
  • 2 locations