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Found 10 clinical trials
Effect of Platelet Inhibition and / or Lipid Lowering in Non-ACS-patients With Positive Troponin

The study evaluates the effect of platelet inhibition and / or lipid lowering in non-ACS-patients with symptoms suggestive for ACS, and elevated high-sensitivity troponin values

  • 6 views
  • 08 May, 2021
  • 7 locations
Safety and Efficacy of Drug-Coated Balloon for De-novo Lesions in Patients With Acute Coronary Syndromes (DCB-ACS)

The DCB-ACS trial is a prospective, multi-center, non-inferiority, randomized controlled trail. The purpose of this trial is to evaluate the safety and efficacy of drug-coated balloon(DCB) in de novo lesions for acute coronary syndromes (ACS) .

zotarolimus
infarct
coronary artery stenosis
myocardial infarction
percutaneous coronary intervention
  • 0 views
  • 04 Jul, 2021
  • 1 location
Daily Vitamin D for Sickle-cell Respiratory Complications

This study aims to answer the question whether daily oral vitamin D supplementation can reduce the risk of respiratory or lung complications in children and adolescents with sickle cell disease. Respiratory problems are the leading causes of sickness and of death in sickle cell disease. The investigators hypothesize that daily …

sickle cell disease
sickle cell anemia
hemoglobin s
vitamin d supplementation
hb s
  • 1 views
  • 11 Jul, 2021
Imatinib for Pain in Sickle Cell Anemia

, and possibly acute chest syndrome and utilization of opioids. The study duration is planned as 6 months in order to provide adequate time for potential change in the primary endpoints (e.g. percent

  • 0 views
  • 26 Feb, 2021
  • 2 locations
High-flow Oxygen for Vaso-occlusive Pain Crisis

Sickle cell disease (SCD) is characterized by recurrent vaso-occlusive pain crisis (VOC), which may evolve to acute chest syndrome (ACS), the most common cause of death among adult patients with

acute pain
opioid
sickle hemoglobin
acute chest syndrome
analgesics
  • 0 views
  • 25 Jan, 2021
  • 1 location
Sickle Cell Disease and CardiovAscular Risk - Red Cell Exchange Trial (SCD-CARRE)

The SCD-CARRE trial is a Phase 3, prospective, randomized, multicenter, controlled, parallel two-arm study aimed to determine if automated exchange blood transfusion and standard of care administered to high mortality risk adult SCD patients reduces the total number of episodes of clinical worsening of SCD requiring acute health care encounters …

sickle hemoglobin
hydroxyurea
hemoglobin s
blood transfusion
exchange transfusion
  • 24 views
  • 31 Jul, 2021
  • 16 locations
Qualitative Survey of Potential Exercise Activity in Adults With Sickle Cell Anemia (SCA)

The purpose of this study is to assess the potential interventions of exercises in adults with sickle cell anemia (SCA) and cardiopulmonary disease; only including the more severe genotypes of sickle cell disease.

anemia
  • 0 views
  • 01 Aug, 2021
  • 1 location
The Effect of Frailty and Other Geriatric Syndromes on the Prognosis of Elderly Patients With Acute Coronary Syndrome

This is a prospective observational clinical trail which will recruit 1000-1500 participants over 65 years with frailty and acute coronary syndrome (ACS) in Beijing Friendship hospital. The investigators will conduct frailty assessment (FRAIL scale, CFS, SPPB), comorbidities, functional status (Barthel index, ADL, IADL), nutritional risk (MNA-SF), and then observe the …

  • 0 views
  • 25 Jan, 2021
  • 1 location
Acute Kidney Injury in Patients With Sickle Cell Disease

Patients with sickle cell disease may be at risk for acute kidney injury (AKI)during sickle cell crisis (pain or acute chest syndrome). This study will evaluate the role of hemolysis during SCD

acute chest syndrome
anemia
renal injury
thalassemia
acute renal failure
  • 132 views
  • 23 Jan, 2021
  • 1 location
Obesity in Pediatric Sickle Cell Disease: A New Phenomenon

The objective of this project is to determine the prevalence of hypertension, hyperlipidemia and hyperglycemia in the pediatric population with sickle cell disease who are obese in Mississippi compared to those pediatric patients with sickle cell disease who are not overweight/obese. The pediatric hematology department at the University of Mississippi …

  • 0 views
  • 13 May, 2021
  • 1 location