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Found 310 clinical trials
A Randomized Multicenter Phase III Trial Comparing Treatment With R-mini-CHOP With R-mini-CHP + Polatuzumab Vedotin in Patients With Diffuse Large Cell B Cell Lymphoma

4 weeks. The duration of active treatment is 18 weeks in both arms, and patients will be followed up to 36 months after end of treatment. Start of enrollment is planned in Q1 2020, and the last

high grade b-cell lymphoma
indolent lymphoma
follicular lymphoma
vincristine
b-cell lymphoma
  • 2 views
  • 19 Jul, 2021
  • 47 locations
Comprehensive Aneurysm Management Trial (CAM)

treatments, have a better long-term clinical outcome with active treatment or conservative management? when patients are considered ineligible for conservative management, and surgical and

  • 0 views
  • 19 Jun, 2022
  • 2 locations
Evaluation of the Safety and Efficacy of TLD in Patients With COPD (AIRFLOW-3)

The purpose of this study is to confirm the safety and efficacy of the Nuvaira Lung Denervation System (Nuvaira System) in the treatment of COPD.

bronchoscopy
pulmonary rehabilitation
bronchodilator
prednisolone
rehabilitation therapy
  • 435 views
  • 23 May, 2022
  • 33 locations
Study of SRP-4045 (Casimersen) and SRP-4053 (Golodirsen) in Participants With Duchenne Muscular Dystrophy (DMD) (ESSENCE)

The main objective of this study is to evaluate the efficacy of SRP-4045 (casimersen) and SRP-4053 (golodirsen) compared to placebo in participants with DMD with out-of-frame deletion mutations amenable to skipping exon 45 and exon 53, respectively.

muscular dystrophy
duchenne muscular dystrophy
forced vital capacity
deletion mutation
corticosteroids
  • 131 views
  • 07 Jul, 2022
  • 47 locations
MASter-1 Study to Evaluate the Efficacy and Safety of MAS825 in NLRC4-GOF Patients (MAS NLRC4-GOF)

This study is a Phase 2 trial designed to evaluate the clinical efficacy, safety, and tolerability of MAS825 in patients with NLRC4-GOF

  • 0 views
  • 08 Aug, 2022
  • 14 locations
A Study of PRN1008 in Adult Patients With Immune Thrombocytopenia (ITP)

This is a 2 part (Part A and B) adaptive, open-label, dose-finding study of PRN1008 in patients with ITP who are refractory or relapsed with no available and approved therapeutic options, with a platelet count <30,000/μL on two counts no sooner than 7 days apart in the 15 days before …

thrombocytopenia
platelet count
autoimmune thrombocytopenia
  • 462 views
  • 25 May, 2022
  • 28 locations
A Study of PRN1008 in Adult Patients With Immune Thrombocytopenia (ITP)

This is a 2 part (Part A and B) adaptive, open-label, dose-finding study of PRN1008 in patients with ITP who are refractory or relapsed with no available and approved therapeutic options, with a platelet count <30,000/μL on two counts no sooner than 7 days apart in the 15 days before …

thrombocytopenia
platelet count
  • 48 views
  • 13 May, 2022
  • 28 locations
MyopiaX Treatment for the Reduction of Myopia Progression in Children and Adolescents: Safety and Efficacy Investigation (MyopiaX-1)

The purpose of this trial is to investigate the safety and efficacy of MyopiaX - a digital treatment intended to slow the progression of myopia in children and adolescent.

  • 0 views
  • 25 Mar, 2022
  • 3 locations
STOP-MSU: Stopping Haemorrhage With Tranexamic Acid for Hyperacute Onset Presentation Including Mobile Stroke Units

The study is a prospective phase II randomised, double-blind, placebo-controlled investigator-driven trial in acute intracerebral haemorrhage patients. The study has 2 arms with 1:1 randomisation to either intravenous tranexamic acid or placebo and will test the hypothesis that in patients with spontaneous ICH, treatment with tranexamic acid within 2 hours …

intracranial hemorrhage
stroke
hematoma
  • 25 views
  • 20 Apr, 2022
  • 24 locations
Eptinezumab as Preventive Treatment of Migraine in Adults With Migraine (Sunrise)

This study evaluates the efficacy of eptinezumab to prevent migraine in patients with chronic migraine

headache
  • 0 views
  • 22 Jul, 2022
  • 55 locations