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Found 250 clinical trials
Management of the PDA Trial (PDA)

Estimate the risks and benefits of active treatment versus expectant management of a symptomatic patent ductus arteriosus (sPDA) in premature infants.

preterm birth
premature
prematurity
active treatment
  • 88 views
  • 27 Feb, 2022
  • 15 locations
COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19)

-hospitalized adults with SARS-CoV-2 disease for preventing Covid-19 disease progression. To understand if the active treatment arms are superior to placebo in improving viral load, serologic markers

  • 21 views
  • 14 Mar, 2022
  • 8 locations
A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Participants With Pulmonary Hypertension (PH) Due to Chronic Obstructive Pulmonary Disease (COPD) (PERFECT)

Distance (6MWD) following 12 weeks of active treatment in participants with PH-COPD.

right heart catheterization
pulmonary disease
treprostinil
forced expiratory volume
left ventricular end-diastolic pressure
  • 2667 views
  • 10 May, 2022
  • 64 locations
Dutch National Randomized Study: PSMA-PET/CT as a Triage Tool for Pelvic Lymph Node Dissection in Prostatectomy Patients

morbidity, with comparable disease prognosis, compared to the current European Guideline-recommended standard practice which includes performing ePLND in PCa patients who are candidates for active treatment

  • 0 views
  • 25 Aug, 2021
  • 1 location
A Randomized Multicenter Phase III Trial Comparing Treatment With R-mini-CHOP With R-mini-CHP + Polatuzumab Vedotin in Patients With Diffuse Large Cell B Cell Lymphoma

4 weeks. The duration of active treatment is 18 weeks in both arms, and patients will be followed up to 36 months after end of treatment. Start of enrollment is planned in Q1 2020, and the last

high grade b-cell lymphoma
follicular lymphoma
b-cell lymphoma
vincristine
indolent lymphoma
  • 2 views
  • 19 Jul, 2021
  • 47 locations
Comprehensive Aneurysm Management Trial (CAM)

treatments, have a better long-term clinical outcome with active treatment or conservative management? when patients are considered ineligible for conservative management, and surgical and

  • 0 views
  • 19 Jun, 2022
  • 2 locations
Evaluation of the Safety and Efficacy of TLD in Patients With COPD (AIRFLOW-3)

The purpose of this study is to confirm the safety and efficacy of the Nuvaira Lung Denervation System (Nuvaira System) in the treatment of COPD.

bronchodilator
bronchoscopy
prednisone
rehabilitation therapy
pulmonary rehabilitation
  • 426 views
  • 23 May, 2022
  • 33 locations
Study of SRP-4045 and SRP-4053 in Participants With Duchenne Muscular Dystrophy (DMD) (ESSENCE)

The main objective of this study is to evaluate the efficacy of SRP-4045 and SRP-4053 compared to placebo in participants with DMD with out-of-frame deletion mutations amenable to skipping exon 45 and exon 53, respectively.

duchenne muscular dystrophy
deletion mutation
muscular dystrophy
forced vital capacity
corticosteroids
  • 131 views
  • 25 Jan, 2022
  • 45 locations
A Study of PRN1008 in Adult Patients With Immune Thrombocytopenia (ITP)

This is a 2 part (Part A and B) adaptive, open-label, dose-finding study of PRN1008 in patients with ITP who are refractory or relapsed with no available and approved therapeutic options, with a platelet count <30,000/μL on two counts no sooner than 7 days apart in the 15 days before …

thrombocytopenia
platelet count
autoimmune thrombocytopenia
  • 455 views
  • 25 May, 2022
  • 28 locations
A Study of PRN1008 in Adult Patients With Immune Thrombocytopenia (ITP)

This is a 2 part (Part A and B) adaptive, open-label, dose-finding study of PRN1008 in patients with ITP who are refractory or relapsed with no available and approved therapeutic options, with a platelet count <30,000/μL on two counts no sooner than 7 days apart in the 15 days before …

thrombocytopenia
platelet count
  • 16 views
  • 13 May, 2022
  • 28 locations