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Found 251 clinical trials
Study Assessing the Efficacy, Safety and PK of Alpelisib (BYL719) in Pediatric and Adult Patients With PIK3CA-related Overgrowth Spectrum

This is a prospective Phase II multi-center study with an upfront 16-week, randomized, double-blind, placebo-controlled period, and extension periods, to assess the efficacy, safety and pharmacokinetics of alpelisib in pediatric and adult participants with PIK3CA-related overgrowth spectrum (PROS).

  • 09 Jun, 2022
  • 30 locations
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression (RECOVER)

Objectives of this study are to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multiple depression scale assessment tools at 12 months from randomization.

depressive episode
depressive disorder
depressive symptoms
  • 07 Apr, 2022
  • 65 locations
Study of Efficacy and Safety of MIJ821 in Addition to Comprehensive Standard of Care on the Rapid Reduction of Symptoms of Major Depressive Disorder in Subjects Who Have Suicidal Ideation With Intent

Study of efficacy and safety of MIJ821 in addition to comprehensive standard of care on the rapid reduction of symptoms of Major Depressive Disorder (MDD) in subjects who have suicidal ideation with intent

  • 19 Jun, 2022
  • 32 locations
National Adaptive Trial for PTSD Related Insomnia (NAP)

Many Veterans with posttraumatic stress disorder (PTSD) have trouble sleeping or have frequent nightmares. So far, no medication has been approved for treatment of insomnia in PTSD. The purpose of this research study is to find out if taking medications called trazodone, eszopiclone, or gabapentin can help decrease symptoms of …

behavior therapy
poor sleep
wake up
  • 27 Jun, 2022
  • 34 locations
HyaloFAST Trial for Repair of Articular Cartilage in the Knee (FastTRACK)

The purpose of this study is to evaluate the safety and efficacy of Hyalofast scaffold with bone marrow aspirate concentrate (BMAC) compared to microfracture in the treatment of symptomatic cartilage defects of the knee.

  • 26 Jan, 2022
  • 24 locations
Adaptive Efficacy and Safety Study of Glenzocimab Used as an add-on Therapy on Top of Standard of Care un the 4.5 Hours Following an Acute Ischemic Stroke

A randomized, double blind, multicenter, multinational, placebo controlled, parallel group, single dose, adaptive phase II/III study (respectively Part 1 and 2). The study evaluates the efficacy and safety of a fixed dose of glenzocimab (1000 mg IV over 6 hrs including initial bolus of 15 minutes) on top of the …

  • 13 Oct, 2021
  • 1 location
Efficacy of Topical Treatment With Clobetasol in Symptomatic Oral Lichen Planus.

will receive active treatment both in the morning an evening. Group two receives placebo in the morning and active treatment in the evening. Group three will get placebo both in the morning and in the

Accepts healthy volunteers
lichen planus
  • 29 Apr, 2022
  • 2 locations
N-Acetylcysteine for Youth Cannabis Use Disorder

negative urine cannabinoid tests during the 12-week active treatment, compared between groups.

  • 15 Feb, 2022
  • 1 location
Scoliosis-specific Exercises for Mild Idiopathic Scoliosis

skeletal maturity without active treatment. If progression occurs and treatment is required, standard treatment consists of bracing 20 hours or more per day. Scoliosis-specific exercises have been reported

  • 23 Apr, 2022
  • 2 locations
Galcanezumab for Vestibular Migraine

effective in reducing or eliminating symptoms in VM. Therefore, the investigators propose a pilot study of changes in VM-PATHI scores, comparing active treatment (Galcanezumab) to placebo arms.

  • 06 Apr, 2022
  • 1 location