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Found 109 clinical trials
Treating Persistent Post-concussion Symptoms With Exercise

The objective of this study is to investigate an aerobic exercise program as a treatment for adults with persistent post-concussive symptoms (PPCS) following mild traumatic brain injury. In this step-wise trial participants will be initially randomized into either a 6-week low-impact stretching protocol or 12-week aerobic exercise protocol. Following the …

concussion
aerobic exercise
traumatic brain injury
post-concussion syndrome
  • 24 views
  • 08 Feb, 2022
  • 1 location
Suvorexant: A Dual Orexin Receptor Antagonist for Treating Sleep Disturbance in Posttraumatic Stress

Post-traumatic stress disorder (PTSD) is a common consequence of combat that can result in trauma-related hyperarousal and sleep disturbances. Poor sleep, one of the most common complaints in Veterans with PTSD, can be distressing, impair concentration and memory, and contribute to physical health conditions, such as metabolic syndrome, inflammation, and …

poor sleep
cardiovascular disease
paroxetine
selective serotonin reuptake inhibitors
duloxetine
  • 132 views
  • 27 Feb, 2022
  • 2 locations
Relationship of Exercise, Sleep, and Inflammation Markers in People Living With HIV (REST)

The purpose of this randomized clinical trial is to characterize the effects of two exercise interventions, high-intensity interval training (HIIT) and continuous moderate-intensity exercise (CME), on sleep and inflammation in older people living with HIV (PWH). This study is a sub-study associated with The High Intensity Exercise Study to Attenuate …

hiv-1 rna measurement
HIV Vaccine
antiretroviral therapy
  • 0 views
  • 23 Mar, 2022
  • 2 locations
rTMS for Stimulant Use Disorders (CTN-0108)

The purpose of the study is to determine feasibility of repetitive transcranial magnetic stimulation (rTMS) for individuals with moderate to severe cocaine or methamphetamine use disorder (CUD/MUD). Potential participants will be age 18-65, and interested in cutting down or stopping use. Participants will be randomized to one of two groups; …

benzodiazepines
stimulant
  • 0 views
  • 25 Mar, 2022
  • 4 locations
Comparing Brief Behavioral Therapy (BBT-CI) and Healthy Eating Education Learning (HEAL) for Cancer-Related Sleep Problems While Receiving Chemotherapy

This phase III trial compares BBT-CI to HEAL for the reduction of insomnia in patients with stage I-III cancer who are receiving chemotherapy. Chemotherapy can cause side effects such as sleep problems. Sleep problems such as insomnia, are common for cancer patients. Insomnia can be described as difficulty falling asleep, …

cancer
  • 0 views
  • 09 Jun, 2022
  • 4 locations
Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin

The purpose of this study is to determine if prazosin is more effective than placebo in decreasing frequency, severity, disability, and other negative effects of headaches related to mild traumatic brain injury in Service Members and Veterans.

post concussion syndrome
traumatic brain injury
coma
amnesia
confusion
  • 59 views
  • 23 Feb, 2022
  • 1 location
Project REST: Regulation of Eating and Sleep Topography

Overweight/obesity and inadequate sleep are prevalent, and frequently co-occurring, health risks among children, both of which are associated with serious medical and psychosocial health complications including risk for cardiovascular disease. Although the investigator's data suggest that disrupted or shortened sleep may be causally associated with increased energy intake and weight …

cardiovascular disease
manipulation
Accepts healthy volunteers
  • 297 views
  • 22 Mar, 2022
  • 1 location
High-Intensity Exercise to Attenuate Limitations and Train Habits in Older Adults With HIV (HEALTH)

This is a multi-site, randomized, single-blind (researchers), active treatment concurrent control trial with individuals aged 50-80 living with HIV who experience fatigue and live a sedentary lifestyle. The overall goals of this proposal are to determine whether high-intensity interval training (HIIT) can overcome physical function impairments and increased fatigue (Aim …

hiv-1 rna measurement
HIV Vaccine
antiretroviral therapy
  • 0 views
  • 23 Mar, 2022
  • 1 location
An Exploratory Clinical Study on Autophagy and Multi-level Molecular Profiling During Spermidine Supplementation

Recently, the autophagy inducing caloric restriction mimic spermidine became available. Autophagy is essential for energy and cellular homeostasis through protein catabolism and dysregulation results in compromised proteostasis, stress-coping behavior, and in excessive secretion of signaling molecules and inflammatory cytokines. Antidepressants for example effect autophagy dependent pathways to exert their beneficial …

  • 5 views
  • 08 Apr, 2021
  • 1 location
The Impact of Physical Exercise on Sleep in Colorectal Cancer Patients During Prehabilitation Period

Main objective: To evaluate the bidirectional relationships between physical exercise and sleep parameters, as a part of multimodal prehabilitation intervention, on pre- and postoperative outcomes in surgical patients with colorectal cancer, in an RCT. Secondary objective: to determine whether the levels of anxiety and depression affect these relationships. Objectives are …

  • 2 views
  • 25 Apr, 2022
  • 1 location