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Found 109 clinical trials
Impact of Intravenous Iron Repletion On Mechanisms of Exercise InTolerance in HFpEF (IRONMET-HFpEF) (IRONMETHFpEF)

The primary objective of this study is to determine if the correction of functional iron deficiency by administering a single dose of intravenous iron (ferric derimaltose or Monoferric®) in participants with heart failure with preserved ejection fraction (HFpEF) will improve exercise capacity as measured by the change in peak oxygen …

  • 20 Jun, 2022
  • 1 location
The Influence of Time-Restricted Eating in Patients With Metabolic Syndrome (TIMET)

In a randomized controlled trial, the investigators intend to measure the health impact of TRE in patients with metabolic syndrome (with three or more of the following criteria: increased waist circumference, abnormal cholesterol levels, elevated blood pressure, or elevated blood sugar), who habitually eat for more than 14 hours every …

cholesterol level
blood pressure diastolic
fish oil
  • 25 Mar, 2022
  • 1 location
Glasses for Adolescent Delayed Sleep-Wake Phase Disorder

The purpose of this study is to determine if evening amber glasses combined with stable wake times will show an increase in total sleep time (TST) and an advance in sleep onset times (shift earlier) compared to the control group.

Accepts healthy volunteers
  • 26 Mar, 2022
  • 2 locations
Improving Outcomes for Patients With SDB and Insufficient Sleep

The purpose of this study is to look at how mild sleep disordered breathing (SDB), and not getting enough sleep each night, contribute to daytime sleepiness. The investigators also want to determine the treatment that works best for improving daytime sleepiness. In this study, the investigators are comparing 3 programs …

apnea-hypopnea index
sleep-disordered breathing
self monitoring
  • 18 Aug, 2021
  • 1 location
Suvorexant as an Adjunct to Buprenorphine in Persons Who Use Fentanyl

This is a 4-week, randomized-controlled trial of suvorexant vs placebo in persons with opioid use disorder who have recent fentanyl exposure. Participants will first undergo a 5-day residential phase wherein participants are stabilized on sublingual buprenorphine/naloxone, followed by a 3-week outpatient phase wherein participants are maintained on sublingual buprenorphine/naloxone and …

  • 19 Apr, 2022
  • 1 location
BBTI vs PSR in Musculoskeletal Orofacial Pain Adults

This clinical study aims to compare the efficacy of two brief psychological interventions: Brief Behavioral Therapy for Insomnia (BBIT) and Physical Self-Regulation or (PSR) delivered over telehealth for the management of chronic musculoskeletal orofacial pain conditions (local myalgia, myofascial pain, centrally mediated myalgia) in a tertiary orofacial pain clinic. It …

myofascial pain
  • 12 Nov, 2021
  • 1 location
Music Intervention in the Treatment of Sleep Disorders for Depressed Patients

The purpose of this study is to determine whether music hearing in the evening before going to sleep can improve sleep quality, depressive symptoms and quality of life in patients with affective disorders.

depressive symptoms
sleep disorder
depressed mood
mood disorder
  • 11 May, 2022
  • 1 location
Racial Differences in Circadian and Sleep Mechanisms for Nicotine Dependence, Craving, and Withdrawal

The number one preventable cause of death in the world is tobacco use. Cigarette smoking in particular, costs an estimated $300 billion due to expenses related to medical care and lost productivity. Despite similar smoking prevalence rates, blacks suffer disproportionately from smoking-related harms compared to whites.Sleep disparities such as shortened …

cigarette smoke
poor sleep
tobacco smoke
nicotine product
nicotine dependence
  • 19 Jun, 2022
  • 1 location
CBT to Reduce Insomnia and Improve Social Recovery in Early Psychosis (CRISP)

Sleep disturbances and cognitive dysfunction are consistently reported as extremely troublesome aspects of psychotic illnesses. While sleep disturbances are not included in definitions of psychosis they are associated with poor levels of daily function and impaired social recovery. Despite sleep problems being documented as co-occurring with psychosis, sleep remains unexamined …

cognitive therapy
psychotic symptoms
  • 24 Mar, 2022
  • 1 location
Bright Light Exposure in Critical Ill Patients

Elucidate the influence of intense light therapy pretreatment in patients undergoing cardiac surgery. We hypothesize that intense light exposure is associated with the peripheral stabilization of Per2 in human buccal swabs and plasma samples before surgery and with a decrease of Troponin I levels after surgery. In addition, we hypothesize …

troponin i
heart surgery
  • 16 May, 2022
  • 1 location