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Found 109 clinical trials
Solriamfetol in Improving Sleep in Patients With Grade II-IV Glioma (JAZZ)

This phase II trial studies the side effects of solriamfetol in improving sleep in patients with grade II-IV glioma. Solriamfetol is a wakefulness-promoting drug. Giving solriamfetol may improve sleep, memory, fatigue, mood, or quality of life in patients with brain tumors (gliomas).

brain tumor
karnofsky performance status
mgmt gene
chemoradiotherapy
tumor progression
  • 120 views
  • 21 Mar, 2022
  • 1 location
Neurocognition After Perturbed Sleep (NAPS)

Individuals with schizophrenia display a wide range of neurocognitive difficulties resulting in functional impairment and disability. Extensive evidence indicates insomnia and sleep disturbances play a substantial role in degrading cognitive functioning. However, the putative impact of insomnia and sleep disturbances on neurocognition and daily functioning has not been investigated in …

schizophreniform disorder
antipsychotics
  • 0 views
  • 19 Apr, 2022
  • 1 location
Targeted Intervention for Insufficient Sleep Among Typically-Developing Adolescents (TAPAS)

The overall aim of Dr. Levenson's research proposal is to test the acceptability, feasibility, and preliminary outcomes of a sleep promotion program delivered to 13-15 year olds who report insufficient sleep. Dr. Levenson will examine the feasibility and acceptability of the program through a randomized pilot trial (n=40) that uses …

Accepts healthy volunteers
polysomnography
  • 0 views
  • 16 Jun, 2022
  • 1 location
Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging

The study will examine whether 5mg melatonin (over the counter, OTC) over a 9-month period improves Alzheimer's disease (AD) biomarkers and cognitive function in two groups of individuals: those with mild cognitive impairment (MCI+) and those who are not (MCI-). AD biomarkers will be measured from cerebrospinal fluid (CSF) obtained …

cognitive impairment
cognitive assessment
halcion
mild cognitive impairment
alzheimer's disease
  • 1 views
  • 15 Mar, 2022
  • 1 location
Recurrent Hypoglycemia in Type 1 Diabetes (Aim 1)

This study will explore the cerebral mechanisms of impaired awareness of hypoglycemia (IAH) in type 1 diabetics following exposure to experimental recurrent hypoglycemia (HG). To induce IAH, patients with T1D identified to have normal awareness of hypoglycemia (NAH) will undergo three 2-hour long hypoglycemic clamps. Neurochemical profiles will be measured …

glycosylated hemoglobin
hypoglycemia
hemoglobin a1c
hypoglycemic drugs
diabetes
  • 60 views
  • 03 Mar, 2022
  • 1 location
Circadian Mechanisms Underlying Non-Dipping Blood Pressure in Blacks

This study seeks to examine central and peripheral circadian mechanisms in Blacks with appropriately dipping systolic blood pressure (blood pressure that dips by at least 10%) compared with non-dipping systolic blood pressure (blood pressure that dips by less than 10%) using a constant routine protocol. Constant routine protocols are commonly …

Accepts healthy volunteers
  • 0 views
  • 13 Apr, 2022
  • 1 location
The Circadian Rhythm of ICU Patients With Acute Myocardial Infraction and the Effect of Light Therapy

By using subjective and objective measurements, the investigators monitore the change of circadian rhythm in Intensive Care Unit (ICU) patients with acute myocardial infarction and the effect of light therapy.

  • 0 views
  • 19 Jul, 2021
  • 1 location
Recurrent Hypoglycemia in Type 1 Diabetes (Aim 2)

This study will explore the cerebral mechanisms of impaired awareness of hypoglycemia (IAH) in type 1 diabetics following exposure to experimental recurrent hypoglycemia (HG). To induce IAH, patients with T1D identified to have normal awareness of hypoglycemia (NAH) will undergo three 2-hour long hypoglycemic clamps. Neurochemical profiles will be measured …

glycosylated hemoglobin
hypoglycemia
hemoglobin a1c
hypoglycemic drugs
hyperglycemia
  • 0 views
  • 05 Oct, 2021
  • 1 location
Sleep Subtypes in Adolescent Depression

The purpose of this study is to compare sleep neurophysiology and behavior in adolescents with MDD with hypersomnia (MDD-HYP) and insomnia (MDD-INS) with healthy controls (HC). In addition, the investigators will test the efficacy of a simple behavioral sleep restriction on mood and sleep in their sample.

insomnia
depression
major depressive disorder
Accepts healthy volunteers
  • 4 views
  • 29 May, 2022
  • 1 location
Reducing Suicide Risk in Adolescents and Young Adults Via a Psychobehavioral Intervention to Regularize Daily Rhythms and Improve Brain Circuitry Functioning

The purpose of this study is to advance a non-pharmacologic suicide preventive intervention with wide dissemination potential as an innovative high-yield solution to reduce suicide rates. The investigators aim to achieve this with this study of Brain Emotion Circuitry Self-Monitoring and Regulation Therapy for Daily Rhythms (BE-SMART-DR), a modification of …

depressive disorder
suicide
bipolar disorder
  • 0 views
  • 17 Jun, 2022
  • 2 locations