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Found 81 clinical trials
Inhibition of CArbonic Anhydrase in Combination With Platinum and Etoposide-based Radiochemotherapy in Patients With Localized Small Cell Lung Cancer (ICAR)

The investigators propose to study the carbonic anhydrase inhibition (acetazolamide) associated with concomitant radiochemotherapy in localized small cell lung cancer due to: The over-expression of carbonic anhydrases in this type of cancer, The Anti-tumor effect in preclinical acetazolamide in various tumor lines including neuroendocrine tumor lines, The observed synergy between …

cancer chemotherapy
neuroendocrine tumor
  • 25 Mar, 2022
  • 1 location
Development of Advanced Double Intravenous Vasopressor Automated (ADIVA) System

Maternal hypotension during spinal anaesthesia for Caesarean delivery may bring various adverse effects. It is therefore important to closely monitor hypotension during spinal anaesthesia, however current technology does not allow the blood pressure monitoring to respond in timely manner should there be any occurrence of hypotension. The investigators developed an …

elective cesarean delivery
spinal anesthesia
  • 27 Jan, 2021
  • 1 location
Comparison of Vasopressor Boluses for Management of Hypotension After Spinal Anesthesia

In this study the investigators will compare the efficacy and side effects of two doses of norepinephrine bolus (6 mcg and 10 mcg) in management of maternal hypotensive episode after subarachnoid block during Cesarean delivery.

  • 15 Feb, 2022
  • 1 location
Ketogenic Diet Following Moderate to Severe Pediatric Traumatic Brain Injury

The primary objective of this study is to evaluate the feasibility and safety of using the ketogenic diet (KD) in children who sustained moderate to severe traumatic brain injury (TBI). The secondary objective is a preliminary evaluation of the outcomes of children who have had the standard of care plus …

severe traumatic brain injury
traumatic brain injury
  • 09 Dec, 2021
  • 1 location
Multimodal Prehabilitation in Frail and Non-frail Patients Waiting for a Kidney Transplantation (the FRAILMAR Study)

Frailty is very frequent among patients waiting for a kidney transplantation (KT). Frailty and poor fitness powerfully predict mortality, kidney graft survival, and healthcare utilization after KT. Frailty in patients with chronic kidney disease (CKD) displays a constellation of features that characterize a special population. Intervention is essential to improve …

  • 28 Jan, 2021
  • 1 location
Oral Anti Diabetic Agents in the Hospital

This randomized controlled clinical trial will assess whether continuation of home oral antidiabetic agents during hospitalization can be used as a safe and effective alternative to insulin therapy in the management of diabetes in the hospital. The primary outcome of the study is to determine differences in glycemic control as …

diabetic ketoacidosis
continuous glucose monitoring
antidiabetic agents
  • 04 Jul, 2021
  • 3 locations
Side Effects of Mandibular Advancement Devices

Sleep-related breathing disorders (SBAS) are one of the most common causes of non-restorative sleep. Sleep therapy options include positive pressure ventilation with continuous positive airway pressure (CPAP) masks, mandibular advancement of the mandible with mandibular advancement devices (MAD), back restraining, weight reduction, ear, nose and throat surgical procedures, bimaxillary or …

body mass index
continuous positive airway pressure
mandibular advancement
  • 10 Oct, 2021
  • 9 locations
Comparison of Potassium Binders in the ER

Compare efficacy of 3 oral potassium binders (cation exchange resins) on lowering blood potassium, in patients presenting to the Emergency Room with acute hyperkalemia.

  • 20 Aug, 2021
  • 1 location
Effects of Large Tidal Volumes Despite Minimal Inspiratory Support in Spontaneously Ventilated Intubated Resuscitation Patients. Pathophysiological Exploratory Study.

Some ICU ventilated patients might present with large tidal volume despite very low or inexistant presser support. Patient-Self Inflicted Lung Injury (P-SILI) might appear related with large alveolar stretch an distension. Two clinical presentations are observed: patients with or without respiratory distress signs such as supra-clavicular depression and thoracic-abdominal asynchronies. …

positive end expiratory pressure
mechanical ventilation
  • 06 Oct, 2021
  • 1 location
Effects Generated on Arterial pCO2 by Postural Changes From 45 to 10 ° in ARDS Patients

Hypercapnia (arterial carbon dioxide levels more than 50 mmHg) is a severity and mortality marker in Acute respiratory distress syndrome (ARDS) patients. In this way, arterial carbon dioxide (pCO2) reduction has been the reason for multiple therapeutic strategies. Therefore, we hypothesized that a 45 to 10 ° postural change in …

acute respiratory distress
assisted breathing
mechanical ventilation
carbon dioxide
  • 12 May, 2022
  • 2 locations