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Found 81 clinical trials
Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency: (DCA/PDCD)

dehydrogenase complex (PDC). PDC deficiency (PDCD) is the most common cause of congenital lactic acidosis and is a frequently fatal metabolic disease of childhood for which no proven treatment exists. The

  • 2 views
  • 26 Jan, 2022
  • 9 locations
L-Citrulline Dose Finding Safety Study in MELAS

metabolism called Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes (MELAS). Once established, this dose will be used in a future clinical trial.

  • 0 views
  • 06 May, 2022
  • 1 location
Optimal Dosage of Acetazolamide for OSA Treatment

Acetazolamide, a carbonic anhydrase inhibitor, has received some attention as potential treatment for obstructive sleep apnea (OSA). It produces a metabolic acidosis by excreting bicarbonate

  • 0 views
  • 30 May, 2021
  • 1 location
Efficacy of Metformin as add-on Therapy in Non-Diabetic Heart Failure Patients

related to the safety of metformin in such diabetic patients due to the risk of lactic acidosis. However, recent studies showed that metformin was safe or even beneficial in HF patients. We hypothesized

chronic heart failure
beta blockers
metformin
aldosterone
angiotensin ii receptor antagonists
  • 0 views
  • 21 Mar, 2022
  • 1 location
The KHENEREXT Study

This is an open-label, multi-centre study in subjects with a genetically confirmed mitochondrial deoxyribonucleic acid (DNA) transfer ribonucleic acid (tRNA)Leu(UUR) m.3243A>G mutation who completed study KH176-202. In the KH176-203 study subjects will be receiving KH176 100 mg BID or KH176 50 mg bid in die (BID) (as determined by the …

  • 0 views
  • 25 Jan, 2022
  • 2 locations
Comparing Mortality for Low vs High Peripheral Oxygen Saturation in COPD-patients With Acute Exacerbation (O2flow-COPD)

-day all-cause mortality, need for non-invasive ventilation, intubation or intensive care admission, over-all length of hospital stay and respiratory acidosis. We believe that a lower oxygen

non-invasive ventilation
pulmonary disease
dyspnea
intubation
  • 2 views
  • 26 Feb, 2022
  • 1 location
Ultraprotective Ventilation Without Extracorporeal Circulation During COVID 19 Pneumonia

extracorporeal circulation may be applied in approximately 2/3 of the patients, with a 4 cmH2O median reduction in driving pressure, at the price of transient episodes of severe acidosis in approximately 1/3 of

  • 0 views
  • 25 Feb, 2021
  • 11 locations
Efficacy of Morphine in Reducing the Rate of Early Non-Invasive Ventilation Failure in Acute Exacerbation of Chronic Obstructive Pulmonary Disease Phase I/IIa

hypercapnia and acidosis, Non Invasive Ventilation (NIV) is preferred as a first line treatment. NIV failures are not uncommon, from 15% in intensive care to 25 - 30% in emergency departments. They

  • 0 views
  • 23 Jul, 2021
  • 1 location
Dapagliflozin in Physical Exercise in Type 1 Diabetes

to acidosis. The underlying mechanisms of this observation are unknown. Ketone body production depends on the molar ratio of glucagon to insulin, with insulin suppressing but glucagon stimulating

  • 0 views
  • 07 Apr, 2021
  • 1 location
Comparison of Safety and Efficacy of Detaenial Sigmoid Neobladder and Ileal Neobladder

which caused anemia, metabolic acidosis, intestinal dysfunction. Not only that, as time goes by, this kind of neobladder will be unlimited expansion and resulting in a serious increase in residual urine

cancer
urinary diversion
bladder tumor
invasive bladder cancer
carcinoma
  • 0 views
  • 25 Jun, 2021
  • 1 location