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Found 83 clinical trials
Influence of Dexmedetomidine or Propofol on ICU Delirium

In this randomized study, the investigators aim to test the hypothesis that the reinstitution of a normal circadian rhythm by continuous infusions of dexmedetomidine compared to propofol between 8pm and 6am after diagnosis of hyperactive or mixed delirium, decreases the duration of delirium. The infusions might have to be repeated …

  • 24 Apr, 2022
  • 1 location
Sodium Bicarbonate for the Treatment of Severe Metabolic Acidosis With Moderate or Severe Acute Kidney Injury in ICU (BICARICU-2)

Severe metabolic acidemia in the critically ill (pH equal or less than 7.20; PaCO2 equal or less than 45mmHg and bicarbonate concentration equal or less than of 20 mmol/l) is associated with a 50% rate of day 28 mortality. Moderate to severe acute kidney injury is a frequent cause of …

critical illness
renal injury
  • 23 Mar, 2022
  • 1 location
Plasmalyte Versus Saline in Trauma Patients

acidosis and to a drop in renal perfusion after isotonic saline infusion. For this reason, we wonder whether fluid resuscitation with Plasmalyte would be beneficial for renal function of trauma patients in

renal injury
kidney function tests
  • 06 Dec, 2021
  • 1 location
PRone positioN in Patients With spontanEous ventiLation and Acute Hypoxemic respIratory FailurE (PRONELIFE)

The proposed randomized controlled trial aims at comparing the application of the prone position in spontaneously breathing patients with acute hypoxemic respiratory failure from any cause versus standard treatment on the rate of invasive mechanical ventilation or all-cause of mortality. The secondary endpoints will include time to tracheal intubation and …

  • 13 Apr, 2022
Lung UltrasouNd Guided Surfactant Therapy in Preterm Infants (LUNG Study) (LUNG)

The investigators hypothesized that the use of lung ultrasound (LU) for measuring RDS severity and deciding surfactant treatment thresholds might decrease the incidence of early and late sequelae in the study group. Thus, a timely surfactant therapy would eventually improve short (e.g. Need of mechanical ventilation in the first 3 …

  • 24 May, 2022
  • 7 locations
Meglimine Sodium Succinate for Correction of Metabolic Acidosis in Critically Ill Patients

An acid-base imbalance, called metabolic acidosis (acid-base disorder lasting from several minutes to several days, caused by a decrease in serum bicarbonate ion (HCO3) concentration), is often

  • 12 Dec, 2021
  • 6 locations
Effect of Alkali Therapy on Vascular and Graft Function in Kidney Transplant Recipients

Lower serum bicarbonate levels, even within the normal laboratory range, in kidney transplant recipients (KTRs) are associated with an increased risk of graft loss, cardiovascular events and mortality. Because acid retention is common in KTRs, it is plausible that alkali therapy in KTRs may also result in improved vascular and …

  • 20 Dec, 2021
  • 1 location
Study of the Effect of SZC on Serum Potassium and Serum Bicarbonate in Patients With Hyperkalemia and Metabolic Acidosis Associated With Chronic Kidney Disease (NEUTRALIZE)

The main objective of this study is to evaluate the efficacy of SZC as compared to placebo in maintaining normal sK+ in patients with hyperkalemia and metabolic acidosis associated with

  • 16 May, 2022
  • 34 locations
Bicarbonate Administration and Cognitive Function in Midlife and Older Adults With CKD

This is a pilot, randomized, double-blinded, placebo-controlled, 12-month trial of 50 patients with CKD stage 3b-4 with metabolic acidosis to examine the effect of sodium bicarbonate therapy on

  • 19 Dec, 2021
  • 1 location
Thiamine as Adjunctive Therapy for Diabetic Ketoacidosis

This is a randomized, double-blind, placebo-controlled trial to determine if administration of intravenous thiamine will lead to quicker resolution of acidosis in patients admitted to the

diabetic ketoacidosis
  • 16 Dec, 2021