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Found 276 clinical trials
Featured trial
Clinical Study for Treatment-naïve IOPD Babies to Evaluate Efficacy and Safety of ERT With Avalglucosidase Alfa (Baby-COMET)  

This is a single group, treatment, Phase 3, open-label study to assess efficacy, safety, pharmacokinetic (PK), pharmacodynamics (PD) of avalglucosidase alfa in treatment-naïve male and female participants with IOPD. Study details include: Study duration: Screening - up to 4 weeks; Primary Analysis Period (PAP) - 52 weeks; Extended Treatment Period …

deficiency
replacement therapy
  • 8 views
  • 31 Jan, 2023
  • 3 locations
Featured trial
Study to Evaluate the Efficacy and Safety of Venglustat in Adult and Pediatric Patients With Gaucher Disease Type 3 (LEAP2MONO)  

This is a parallel arm, Phase 3, double-blind, double-dummy, active-comparator, 2 arm study to evaluate the efficacy and safety of daily oral venglustat versus intravenous Cerezyme infusions every two weeks for improvement or stabilization of the neurological manifestations and maintenance of systemic disease stability in participants aged ≥12 and <18 …

platelet count
cerezyme
bone pain
deficiency
alglucerase
  • 9 views
  • 02 Feb, 2023
  • 1 location
Featured trial
Persistent Acid Reflux Disease

Acid Reflux, Heartburn and currently taking proton pump inhibitors  

  • 343 views
  • 23 Nov, 2020
  • 1 location
Featured trial
The effect of daily intake of two different doses of Bifidobacterium Breve Bif195 on small-intestinal damage induced by Acetlysalicylic Acid- a randomized, double-blind, placebo-controlled, three-armed, parallel group trial in healthy volunteers.

Non-Steroidal-Anti-Inflammatory Drugs (NSAIDs), such as Aspirin, are commonly used worldwide, both as prescription-only medicines and as “over-the-counter” medications. They are often used in the treatment of many common pain-related conditions, including headaches and menstrual pain, and for long-term treatment of chronic inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Long-term use …

  • 848 views
  • 23 Nov, 2020
  • 1 location
Featured trial
Dietary Omega-7 Palmitoleic Acid-Rich Oil on Lipoprotein Metabolism and Satiety in Adults

Background: Omega-7 fatty acids are found in the oil extracted from certain fish and nuts like macadamia. Palmitoleic acid is one of the most common omega-7 fatty acids. Many studies suggest that this oil is good for heart health. Researchers want to find out more about these potential benefits. Objective: …

fatty acids
fish oil
  • 193 views
  • 23 Nov, 2020
  • 1 location
Featured trial
Randomized Global Phase 3 Study to Evaluate the Impact on NASH With Fibrosis of Obeticholic Acid Treatment (REGENERATE)

Randomized Global Phase 3 Study to Evaluate the Impact on NASH With Fibrosis of Obeticholic Acid Treatment (REGENERATE)

  • 237 views
  • 23 Nov, 2020
  • 1 location
TRAnexamic Acid for Preventing Blood Loss Following a Cesarean Delivery in Women With Placenta pREVIA (TRAAPrevia)

Several randomized, controlled trials, mostly involving women undergoing cesarean delivery, have shown that the prophylactic intravenous administration of 1 g of tranexamic acid after childbirth reduced blood loss. Most were small, single-centre trials with considerable methodologic limitations. It is important to emphasize that none of these RCTs has included women …

placenta previa
cesarean section
tranexamic acid
  • 0 views
  • 24 Apr, 2022
  • 1 location
A Trial of a Hospital Policy of Tranexamic Acid Use to Reduce Transfusion in Major Non-cardiac Surgery (TRACTION)

A Phase IV trial of a hospital policy of Tranexamic acid to reduce transfusion in major non-cardiac surgery.

  • 0 views
  • 19 Apr, 2022
  • 1 location
Effect of MIST on Esophageal Sensitivity in Patients With rGERD (MIST)

Effect of acute psychosocial stress on esophageal sensitivity in patients with refractory gastro-esophageal reflux disease and healthy volunteers.

  • 0 views
  • 13 Jul, 2022
  • 1 location
Stretta Treatment in GERD After SG

To evaluate the effect and explore the mechanism of action behind the potential effect of Stretta on GERD after SG.

  • 11 views
  • 10 Nov, 2021
  • 1 location