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Found 5723 clinical trials
Randomized Trial to Examine a Differential Therapeutic Response in Symptomatic Patients With Non-obstructive Coronary Artery Disease (EXAMINE-CAD)

EXAMINE-CAD-DZHK22 is a prospective, randomized, double-blind, placebo-controlled, crossover trial investigating the efficacy of beta blocker (bisoprolol) and calcium channel blocker (diltiazem) therapy in symptomatic patients with non-obstructed coronary arteries according to coronary physiological testing results.

artery disease
coronary artery stenosis
channel blockers
angina symptoms
  • 13 Apr, 2022
'Understanding the Electrophysiological Substrate Underlying Persistent Atrial Fibrillation Study II (USURP AF- Study II)' (USURPAF)

Atrial fibrillation (AF) is the most common type of chronic heart rhythm disease worldwide, with significant associated co-morbidities. Although there have been advances in understanding the mechanisms of AF, the underlying cause of AF and factors which perpetuate it remain incompletely understood. This is particularly the case for persistent AF …

pulmonary vein isolation
persistent atrial fibrillation
  • 14 Feb, 2022
  • 1 location
Skin-to-skin Contact in Neonatal Intensive Care Unit (NICU), Caregiving Touch and Neural Correlates of Slow Stroking Touch in Preterm Infants

Preterm (PT) infants spend their first weeks of life in Neonatal Intensive Care Unit (NICU) where receive little affective physical contact, which plays a crucial role in brain development. Evidence indicates that skin-to-skin contact (SSC) has a positive effect on infants' neurophysiological and behavioral adjustment to postnatal life. Moreover, caregiving …

Accepts healthy volunteers
  • 28 Feb, 2022
  • 1 location
Patient Reported Outcomes Measures to Predict Pancreatic Surgery Outcomes (PRO-PANC1)

This is a prospective single-center observational study with the mail objective to identify specific subgroups of patients planned for pancreatic resection, at high risk for postoperative morbidity and impaired recovery through preoperative screening of physical, functional, nutritional and psychological risk factors using patient reported questionnaires and performance tests. Consecutive patients …

pancreatic resection
pancreatic surgery
  • 14 Apr, 2022
  • 1 location
Post-radiation Dental Disease Amongst Head and Neck Cancer Patients

Background Post-radiotherapy head and neck cancer (HANC) patients are at increased risk of dental caries and periodontal disease due to radiation-related damage to the teeth and salivary glands. Currently the exact aetiology of post-radiotherapy dental disease, and variation in its incidence and severity based on tumour location and radiotherapy dose, …

  • 22 Jan, 2021
  • 1 location
The Influence of Urate-lowering Therapy on Sperm Quality of Male Gouty Patients A Prospective Cohort Study

Gout is a kind of crystal-associated arthropathy caused by monosodium urate deposition, which is directly related to hyperuricemia caused by purine metabolic disorder and/or decreased uric acid excretion. It belongs to the category of metabolic rheumatism. Gout can be complicated with kidney disease. The severe cases can occur joint destruction, …

serum uric acid
primary gout
type 2 diabetes
heart disease
monosodium urate
  • 23 Sep, 2021
  • 1 location
Brain Activity and Oxygenation Inflammatory Bowel Disease (IBD) Patients

Symptoms such as fatigue, sleep disturbances, anxiety and depression are common in patients with IBD, but the cause is unknown. Understanding how these behaviors occur in IBD and their role in symptoms may help improve management of IBD. How IBD leads to changes in brain function remains unclear. Inflammation and …

  • 10 May, 2021
  • 1 location
Gastro-intestinal Physiology After Anti-Reflux Procedures (GASP)

Gastro-oesophageal reflux disease (GORD) affects 1 in 4 adults and is a condition where stomach acid leaks back up into the oesophagus (gullet). It can cause an uncomfortable burning feeling in the chest and even lead to problems such as cancer of the oesophagus. Thankfully most people feel better by …

  • 07 Jun, 2022
  • 1 location
Feasibility of the PERformance Guided Fracture Rehablitation Method-protocol (PERFoRM)

Introduction: The scientific support for prescribed rehabilitation programs for upper extremity fractures is scarce, early mobilization has previously been shown to benefit the speed of recovery at the activity and participation level. Different (inter)national protocols for fracture rehabilitation of the upper extremity are not very specific with regard to the …

  • 04 Jun, 2022
  • 1 location
Health Indicators and Patient Reported Outcomes. Identification of Significative Items Aimed at Improving Health Care Procceses. (OUTCOMES)

The objective of this study is to identify key indicators in the follow-up of subjects with different pathologies related to both the person's environment, as well as the perception of their health and general quality of life and related to their disease. To this end, a cross-sectional observational study of …

Accepts healthy volunteers
  • 27 May, 2022
  • 1 location