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Found 8 clinical trials
Featured trial
A Placebo-controlled, Double-blind, Parallel-group, Bayesian Adaptive Randomization Design and Dose Regimen-finding Study to Evaluate Safety, Tolerability and Efficacy of BAN2401 in Subjects With Early Alzheimer's Disease

A Placebo-controlled, Double-blind, Parallel-group, Bayesian Adaptive Randomization Design and Dose Regimen-finding Study to Evaluate Safety, Tolerability and Efficacy of BAN2401 in Subjects With Early Alzheimer's Disease

  • 258 views
  • 08 Dec, 2020
  • 1 location
Featured trial
A Phase Ii, Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study To Investigate The Efficacy And Safety Of Ro4602522 Added To The Background Therapy Of The Acetylcholinesterase Inhibitors Donepezil Or Rivastigmine In Patients With Moderate Severity Alzheimer's Disease

A Phase Ii, Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study To Investigate The Efficacy And Safety Of Ro4602522 Added To The Background Therapy Of The Acetylcholinesterase Inhibitors Donepezil Or Rivastigmine In Patients With Moderate Severity Alzheimer's Disease

  • 153 views
  • 25 Mar, 2021
  • 1 location
Comparative Efficacy and Safety of Sugammadex and Neostigmine

the endotrachea tube. Traditionally, acetylcholinesterase inhibitor (AChEI, such as neostigmine, pyridostigmine, edrophonium) is used to reverse the efficacy of NMBA and stabilize the

  • 40 views
  • 10 Sep, 2021
  • 1 location
Enhancing Parasympathetic Activity to Improve Endothelial Dysfunction, Vascular Oxidative Stress in African Americans

Specific Aim 1: To test the hypothesis that prolonged (3-month) treatment with galantamine inhibits NADPH IsoLG-protein adducts formation and improves markers of endothelial cell (EC) dysfunction in AAs. Aim 1a: The investigators will determine if galantamine inhibits NADPH IsoLG-protein adducts formation, superoxide production, and immune cell activation compared to placebo. …

Accepts healthy volunteers
  • 0 views
  • 02 Jan, 2022
  • 2 locations
Efficiency of Donepezil in Elderly Patients for Prevention of POCD Dysfunction

method was proved. According to our previous study, the central cholinergic system impaired by the anesthesia and surgery play a very important role in the POCD and donepezil an acetylcholinesterase

anesthesia
total knee replacement
  • 0 views
  • 28 Jan, 2021
  • 1 location
Effect of Hydralazine on Alzheimer's Disease (EHSAN)

one of the acetylcholinesterase inhibitor (AChEI) donepezil, rivastigmine, or galantamine.

mental state examination
stroke
galantamine
acetylcholinesterase inhibitor
donepezil
  • 0 views
  • 21 Mar, 2022
  • 1 location
Donepezil for Oxaliplatin-induced Neuropathy Peripheral Neuropathy: Proof of Concept Study (DONEPEZOX)

, no treatment remains univocal for these peripheral neuropathies. But preclinical works have demonstrated that donepezil (acetylcholinesterase inhibitor use for Alzheimer's disease) was able to

  • 0 views
  • 08 Jul, 2022
  • 23 locations
The LUCINDA Trial: LeUprolide Plus Cholinesterase Inhibition to Reduce Neurological Decline in Alzheimer's (LUCINDA)

The LUCINDA Trial is a three-site, phase II, randomized, double-blind, placebo-controlled study of leuprolide acetate (Eligard) in women with Mild Cognitive Impairment or Alzheimer's Disease taking a stable dose of donepezil (Aricept.) Its objective is to assess the efficacy of a 48-week regimen of leuprolide (22.5 mg per 12 weeks) …

donepezil
mini-mental state examination
alzheimer's disease
memantine
mild cognitive impairment
  • 47 views
  • 28 Feb, 2022
  • 1 location