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Found 63 clinical trials
Featured trial
Schizophrenia Study

Schizophrenia Study

  • 566 views
  • 08 Nov, 2020
  • 1 location
None
Understanding Factors That Influence Electronic Cigarette Nicotine Delivery Through PET Imaging of Beta-2 Nicotinic Acetylcholine Receptors

The goal of this proposal is to test the overall hypothesis that e-cigarettes (ECs) provide efficient nicotine delivery to the brain and arterial blood in non-EC-nave smokers and e-cigarette users and that EC liquid characteristics modulate this effect. This study will test the hypothesis through complementary methods that include [ …

  • 0 views
  • 02 Jul, 2021
  • 1 location
None
In Vivo Involvement of the Cholinergic and Dopaminergic Systems in the Pathophysiology of Apathy.

of cortico-striato-thalamo-cortical loops, modulated by several neurotransmitter systems including dopamine and acetylcholine, thus complexifying pharmacological management. Post-stroke apathy (PSA

  • 0 views
  • 06 Jun, 2021
  • 1 location
None
Botox Instead of Strabismus Surgery (BISS)

prevents the release of acetylcholine in the synaptic cleft and thereby blocks the neuromuscular transmission thus inducing a palsy. Current evidence on the use of Botox in strabismus is incoherent

  • 51 views
  • 07 Sep, 2021
  • 9 locations
None
Comparative Efficacy and Safety of Sugammadex and Neostigmine

participants's vital signs. However, the reversal of acetylcholine ester inhibitors is slow, the curative effect has a ceiling effect, and the need to use anticholinergics (anticholinergics) to reduce the

  • 40 views
  • 10 Sep, 2021
  • 1 location
None
The Impact of an Epidural Ropivacaine-Neostigmine Injection for Perineal Analgesia at the End of Labor.

Perineal pain after childbirth occurs in the majority of women (with or without episiotomy). Perineal pain can become source of chronic pain in 9%-12% of the cases. Neostigmine a cholinesterase inhibitor at a dose of 500µg combined with Sufentanil or Ropivacaine (=local anaesthetic) is an analgesic. The goal of this …

  • 13 views
  • 07 Nov, 2020
  • 1 location
None
Botox in the Healing of Surgical Wounds of the Neck

The investigators hypothesize that Botox A will reduce scarring and improve healing of surgical neck wounds.

botulinum toxin type a
botox
scarring
botulinum toxin
surgical wound
  • 44 views
  • 08 Nov, 2020
  • 1 location
None
TAME-PD - Physical Therapy Atomoxetine and Methylphenidate to Enhance Gait and Balance in Parkinson's Disease

Gait and balance problems are a significant source of disability in patients with Parkinson disease. Physical therapy remains one of the main treatments. On the other hand some medications, such as methyphenidate and atomoxetine, have been tried with promising results. The outcomes in gait and balance in Parkinson disease after …

medication regimen
  • 15 views
  • 19 Feb, 2021
  • 1 location
None
Coronary Artery Disease in Patients With Friedreich's Ataxia

Friedreich's ataxia is a debilitating, inherited disease cause by mutations in a protein called frataxin (FXN). FXN is one of several proteins that controls the production of iron-sulfur clusters, molecules that are essential for energy production in our cells as well as repair of our genetic code embedded in DNA …

  • 0 views
  • 22 Feb, 2021
  • 1 location
None
Nicotinic Receptor Genetic Variation and Alcohol Reward

Background People with the brain disease AUD (alcohol use disorder) have a serious problem with drinking. Researchers want to study how different people react to alcohol, and how genes affect this. They will focus on a nicotine receptor gene that may increase a person s AUD risk. Objectives To see …

Accepts healthy volunteers
  • 9 views
  • 10 Oct, 2021
  • 1 location