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Found 9 clinical trials
External Counterpulsation Therapy for Severe Steno-occlusive Intracranial Stenosis

Intracranial stenosis is prevalent among Asians and constitute a common cause of cerebral ischemia. While the best medical therapy carries stroke recurrence rates in access of 10% per year, intracranial stenting was associated with unacceptable peri-procedural ischemic events. Cerebral ischemic events are strongly related to the severity of intracranial stenosis, …

acute stroke
stenosis
ischemia
stroke
cerebral infarction
  • 23 views
  • 03 Feb, 2022
  • 1 location
Acetazolamide for Treatment Resistant Schizophrenia (APTS)

This is a double blind adjunctive randomized controlled trial for schizophrenia using acetazolamide.

schizophrenia
  • 0 views
  • 23 Mar, 2022
  • 1 location
Acetazolamide to Prevent Impending Altitude-illness in Patients With COPD

The purpose of this randomized, placebo-controlled double-blind trial is to evaluate efficacy of acetazolamide in preventing overt altitude-related adverse health effects (ARAHE) in lowlanders

  • 0 views
  • 12 Jun, 2021
  • 1 location
Effect of Acetazolamide on Right Heart Function at Rest in Lowlanders With COPD Traveling to High Altitude

The purpose of this randomized, placebo-controlled double-blind trial is to evaluate the effect of acetazolamide on right heart function at rest in lowlanders with chronic obstructive pulmonary

  • 0 views
  • 18 Jun, 2021
  • 1 location
Phase I, Open-Label, Study of Tumor Infiltrating Lymphocytes Engineered With Membrane Bound IL15 Plus Acetazolamide in Adult Patients With Metastatic Melanoma

To find the recommended dose of OBX-115 in combination with acetazolamide that can be given to patients with metastatic melanoma previously treated with immune checkpoint inhibitors.

targeted therapy
fludarabine
BRAF
brain metastases
platelet count
  • 0 views
  • 07 Oct, 2022
  • 1 location
Inhibition of CArbonic Anhydrase in Combination With Platinum and Etoposide-based Radiochemotherapy in Patients With Localized Small Cell Lung Cancer (ICAR)

The investigators propose to study the carbonic anhydrase inhibition (acetazolamide) associated with concomitant radiochemotherapy in localized small cell lung cancer due to: The

cancer chemotherapy
neuroendocrine tumor
etoposide
  • 15 views
  • 25 Mar, 2022
  • 1 location
Combination Drug-Therapy for Patients With Untreated Obstructive Sleep Apnea

offer a more effective treatment approach. The goal of this study is to test the effect of combination therapy with three FDA-approved drugs (Diamox [acetazolamide], Lunesta [eszopiclone] +/- Effexor

  • 4 views
  • 01 Oct, 2021
  • 2 locations
Diuretic Treatment in Acute Heart Failure With Volume Overload Guided by Serial Spot Urine Sodium Assessment (DECONGEST)

This is a pragmatic, multicenter, interventional, parallel-arm, randomized, open-label trial to investigate whether a diuretic regimen, based on serial assessment of sodium concentration (UNa) on spot urine samples after diuretic administration and with low-threshold use of combination diuretic therapy, improves decongestion versus usual care in acute heart failure (AHF), potentially …

  • 0 views
  • 03 Jul, 2022
  • 1 location
Central Sleep Apnea : Physiologic Mechanisms to Inform Treatment (CSA)

Central sleep apnea (CSA) is common in patients with heart failure and those using opioid analgesics. Unfortunately, effective treatment of central apnea remains elusive, pressure therapy given the modest efficiency of positive airway pressure therapy. The focus of this proposal is to identify mechanistic pathways to guide future therapeutic interventions …

Accepts healthy volunteers
apnea-hypopnea index
opioid
heart failure
central sleep apnea
  • 35 views
  • 23 Mar, 2022
  • 1 location