Found 23 clinical trials
The Effect of Ramipril in Suppressing ST2 Expression in Rheumatic Mitral Stenosis Patients
Objective propose: to investigate the effect of Ramipril in suppressing ST2 (suppression of tumorigenicity 2) in the cardiac mitral valve in patients with Rheumatic Heart Disease. We hypothesized that we hypothesized that ramipril will improve rheumatic mitral valve fibrosis through the downregulation of ST2.
- 110 views
- 27 Jan, 2021
- 1 location
Mechanisms Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 3
-converting enzyme (ACE) inhibitor or ARB. After a 48-hour washout, they will undergo a study day in which they are given a single dose of 50 mg LCZ696. They will also receive either the NK1 receptor
- 0 views
- 18 Jul, 2021
- 2 locations
Mechanisms Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 2
angiotensin-converting enzyme (ACE) inhibitor or ARB. After a 48-hour washout, they will undergo a study day in which they are given a single dose of 50 mg LCZ696. They will also receive either the bradykinin
- 2 views
- 06 May, 2021
- 1 location
Oxidative Stress Lowering Effect of Simvastatin and Atorvastatin.
will be stratified for prior ACE-inhibitor use during randomization. All included patients are randomized to treatment with simvastatin 40 mg daily or atorvastatin 10 mg daily to achieve
- 91 views
- 07 Nov, 2020
- 1 location
Treatment of Angiotensin Converting Enzyme Inhibitor-induced Angioedema
Angiotensin Converting Enzyme (ACE) inhibitors are among the most important and widely prescribed drugs. They reduce the morbidity and mortality associated with high blood pressure, heart disease, and kidney disease. Unfortunately, their use carries the risk of causing life-threatening airway swelling in some patients. There is currently no treatment for …
- 0 views
- 27 Jan, 2021
- 1 location
Evaluation of a Renin Inhibitor Aliskiren Compared to Enalapril in C3 Glomerulopathy
The aim of this cross-over trial is to assess aliskiren, a direct renin inhibitor, as a novel treatment to block complement activation in the kidneys and thereby attenuate renal disease and stabilize or improve kidney function and compare it to the currently used treatment with the angiotensin converting enzyme inhibitor, …
- 0 views
- 26 Jan, 2021
- 4 locations
ACES - ACE Inhibitors Combined With Exercise for Seniors With Hypertension
The purpose of this project is to conduct a randomized, controlled trial (RCT) to determine if choice of antihypertensive medication influences changes in functional status and other cardiovascular risk factors among older persons with hypertension when combined with physical exercise.
- 164 views
- 21 May, 2021
- 3 locations
Randomized Placebo-controlled Analysis of Superior Laryngeal Nerve Block for Neurogenic Cough
Prospective randomized placebo-controlled trial assessing the efficacy of superior laryngeal nerve block for adults with neurogenic cough refractory to proton pump inhibitor as determined by improvement in validated cough severity questionnaires before and after injection of Marcaine and Kenalog compared to placebo (saline injection).
- 0 views
- 09 May, 2021
- 1 location
PITA-HF: Feasibility Safety and Tolerability
Heart failure affects over 25 million people worldwide and nearly 7 million adults in the United States alone. Nearly 25% of patients with heart failure have worsened disease burden from dyssynchronous ventricular contraction due to abnormal electrical impulse propagation. These patients may benefit from cardiac resynchronization therapy (CRT) where contraction …
- 0 views
- 20 Jun, 2021
- 1 location
Influenza Vaccination ACEI and ARB in the Evolution of SARS-Covid19 Infection
Some authors have proposed the use of the flu vaccine to reduce the severity of COVID-19 cases, while some have proposed the use of ACE Inhibitors (ACEI) or Angiotensin Receptor blockers (ARB), since this virus shares hemagglutinin as a transmission mechanism and acts on the ACE2 enzyme during infection. The …
- 0 views
- 25 Jan, 2021
- 1 location