Found 20 clinical trials
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Phase 4 trial
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Accepting Seniors
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Accepting adults
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10s of participants
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An interventional trial
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For all genders
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Family Medicine
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Currently Recruiting
Mechanisms Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 2
angiotensin-converting enzyme (ACE) inhibitor or ARB. After a 48-hour washout, they will undergo a study day in which they are given a single dose of 50 mg LCZ696. They will also receive either the bradykinin
- 2 views
- 24 Jan, 2021
- 1 location
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Phase 4 trial
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Accepting Seniors
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Accepting adults
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10s of participants
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An interventional trial
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For all genders
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Endocrinology
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Currently Recruiting
Oxidative Stress Lowering Effect of Simvastatin and Atorvastatin.
will be stratified for prior ACE-inhibitor use during randomization. All included patients are randomized to treatment with simvastatin 40 mg daily or atorvastatin 10 mg daily to achieve
- 91 views
- 07 Nov, 2020
- 1 location
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Phase 2 trial
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Accepting Seniors
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Accepting adults
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10s of participants
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An interventional trial
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For all genders
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Currently Recruiting
Treatment of Angiotensin Converting Enzyme Inhibitor-induced Angioedema
Angiotensin Converting Enzyme (ACE) inhibitors are among the most important and widely prescribed drugs. They reduce the morbidity and mortality associated with high blood pressure, heart disease, and kidney disease. Unfortunately, their use carries the risk of causing life-threatening airway swelling in some patients. There is currently no treatment for …
- 0 views
- 27 Jan, 2021
- 1 location
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Phase 2 trial
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Accepting pediatric ages
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Accepting Seniors
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10s of participants
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An interventional trial
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For all genders
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Nephrology
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Currently Recruiting
Evaluation of a Renin Inhibitor Aliskiren Compared to Enalapril in C3 Glomerulopathy
The aim of this cross-over trial is to assess aliskiren, a direct renin inhibitor, as a novel treatment to block complement activation in the kidneys and thereby attenuate renal disease and stabilize or improve kidney function and compare it to the currently used treatment with the angiotensin converting enzyme inhibitor, …
- 0 views
- 26 Jan, 2021
- 4 locations
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Phase 2 trial
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Accepting Seniors
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Accepting adults
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100s of participants
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An interventional trial
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For all genders
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Neurology
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Currently Recruiting
ACES - ACE Inhibitors Combined With Exercise for Seniors With Hypertension
The purpose of this project is to conduct a randomized, controlled trial (RCT) to determine if choice of antihypertensive medication influences changes in functional status and other cardiovascular risk factors among older persons with hypertension when combined with physical exercise.
- 164 views
- 23 Jan, 2021
- 3 locations
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Accepting Seniors
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Accepting adults
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10s of participants
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An interventional trial
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For all genders
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Family Medicine
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Currently Recruiting
PITA-HF: Feasibility Safety and Tolerability
Heart failure affects over 25 million people worldwide and nearly 7 million adults in the United States alone. Nearly 25% of patients with heart failure have worsened disease burden from dyssynchronous ventricular contraction due to abnormal electrical impulse propagation. These patients may benefit from cardiac resynchronization therapy (CRT) where contraction …
- 0 views
- 27 Jan, 2021
- 1 location
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Multi-country trial
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Phase 4 trial
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Accepting Seniors
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Accepting adults
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100s of participants
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An interventional trial
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For all genders
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Currently Recruiting
Stopping ACE-inhibitors in COVID-19
ACEI-COVID-19 is a multicenter, randomized trial testing the hypothesis that stopping/replacing chronic treatment with ACE-inhibitors (ACEI) or angiotensin receptor blockers (ARB) improves outcomes in symptomatic SARS-CoV2-infected patients
- 40 views
- 25 Jan, 2021
- 25 locations
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Accepting pediatric ages
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Accepting Seniors
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1000s of participants
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An observational study
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For all genders
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Currently Recruiting
Influenza Vaccination ACEI and ARB in the Evolution of SARS-Covid19 Infection
Some authors have proposed the use of the flu vaccine to reduce the severity of COVID-19 cases, while some have proposed the use of ACE Inhibitors (ACEI) or Angiotensin Receptor blockers (ARB), since this virus shares hemagglutinin as a transmission mechanism and acts on the ACE2 enzyme during infection. The …
- 0 views
- 25 Jan, 2021
- 1 location
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Accepting Seniors
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Accepting adults
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1000s of participants
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An observational study
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For all genders
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Family Medicine
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Currently Recruiting
Evaluation and Management of Cardio Toxicity in Oncologic Patients
addition of angiotensin-converting-enzyme inhibitor (ACE inhibitor) and beta blockers to the patient's treatment may prevent the development of cardiac dysfunction. However, currently there are no specific
- 1 views
- 24 Jan, 2021
- 1 location
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Accepting Seniors
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Accepting adults
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10s of participants
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An observational study
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For all genders
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Currently Recruiting
Multimodal IMAgery Characterization of Cardiac Damage and Severity After COVID-19 Infection
ACE inhibitor, beta-blockers, steroids...? ) In this study, the investigators proposed to collect multimodal cardiac imaging including MRI (Magnetic Resonance Imaging) and TTE (Transthoracic
- 0 views
- 23 Feb, 2021
- 1 location
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