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Found 20 clinical trials
Effects of Angiotensin Converting Enzyme Inhibitors on Patency of Arterio-Venous Fistulas: A Randomized Controlled Trial

conflicting results in terms of AVF patency when ACE inhibitors are used in conjunction. A study by Jackson RS and colleagues showed that ACE inhibitor were associated with reduced hazard ratio [HR], 0.35

  • 02 Dec, 2021
  • 1 location
A Study to Learn More About How Well the Study Treatment Finerenone Works, How Safe it is, How it Moves Into, Through, and Out of the Body, and the Effects it Has on the Body When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker in Children With Chronic Kidney Disease and Proteinuria (FIONA)

Researchers are looking for a better way to treat children who have chronic kidney disease (CKD), which is long-term kidney disease, and proteinuria, a condition in which a person´s kidneys leak protein into the urine. The kidneys filter waste and fluid from the blood to form urine. In children with …

ace inhibitor
angiotensin ii receptor antagonists
chronic kidney disease
  • 12 Jul, 2022
  • 11 locations
S1501 Carvedilol in Preventing Cardiac Toxicity in Patients With Metastatic HER-2-Positive Breast Cancer

This phase III trial studies how well carvedilol works in preventing cardiac toxicity in patients with human epidermal growth factor receptor (HER)-2-positive breast cancer that has spread to other places in the body. A beta-blocker, such as carvedilol, is used to treat heart failure and high blood pressure, and it …

brain metastases
human epidermal growth factor
coronary artery disease
ejection fraction
  • 26 Feb, 2022
  • 114 locations
Lokelma for RAAS Maximisation in CKD & Heart Failure. (LIFT)

Background: CKD in patients with heart failure (HF) is common and associated with poor prognosis. Despite evidence of benefit with Renin-Angiotensin-Aldosterone-System inhibitor (RAASi) agents, they are avoided due to fear of hyperkalaemia. New potassium binders, e.g. Sodium Zirconium Cyclosilicate (SZC), reduce incidence of hyperkalaemia in CKD-HF patients and hence may …

heart failure
  • 14 Mar, 2022
A Study of the Safety Tolerability Pharmacokinetics and Efficacy of Treatment With AP1189 in Patients With iMN

membranous nephropathy (iMN) who are on ACE inhibitor or angiotensin II receptor blocker treatment.

kidney biopsy
ace inhibitor
nephrotic syndrome
protein creatinine ratio
  • 30 Sep, 2021
  • 1 location
The Effect of Ramipril in Suppressing ST2 Expression in Rheumatic Mitral Stenosis Patients

Objective propose: to investigate the effect of Ramipril in suppressing ST2 (suppression of tumorigenicity 2) in the cardiac mitral valve in patients with Rheumatic Heart Disease. We hypothesized that we hypothesized that ramipril will improve rheumatic mitral valve fibrosis through the downregulation of ST2.

mitral valve replacement
rheumatic heart disease
tricuspid valve repair
heart disease
  • 10 Feb, 2022
  • 1 location
Centrally Acting ACE Inhibition in SLE

models of lupus and in lupus patients suggest that inflammation due to lupus can affect the brain directly. This research study is being done to test the effects of centrally-acting ACE inhibitor

ace inhibitor
autoimmune disease
  • 29 Nov, 2021
  • 7 locations
Mechanisms Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 2

angiotensin-converting enzyme (ACE) inhibitor or ARB. After a 48-hour washout, they will undergo a study day in which they are given a single dose of 50 mg LCZ696. They will also receive either the bradykinin

natriuretic peptide
ejection fraction
beta blockers
beta-adrenergic blocking agents
b-type natriuretic peptide
  • 14 Jun, 2022
  • 1 location
Treatment of Angiotensin Converting Enzyme Inhibitor-induced Angioedema

Angiotensin Converting Enzyme (ACE) inhibitors are among the most important and widely prescribed drugs. They reduce the morbidity and mortality associated with high blood pressure, heart disease, and kidney disease. Unfortunately, their use carries the risk of causing life-threatening airway swelling in some patients. There is currently no treatment for …

  • 12 Mar, 2022
  • 1 location
Effect of Olmesartan on Angiotensin(1-7) Levels and Vascular Functions in Diabetes and Hypertension (Ang(1-7))

In this study, we will assess the change of serum ACE-2, angiotensin(1-7), and vascular function after using olmesartan (an ARB), compared to conventional anti-hypertensive drug, amlodipine in hypertensive patients with T2DM.

blood pressure diastolic
  • 21 Mar, 2022
  • 1 location