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Found 69 clinical trials
PreOperative Endocrine Therapy for Individualised Care With Abemaciclib (POETIC-A)

pre-surgery. Eligible patients will be randomised to standard adjuvant endocrine therapy alone or standard adjuvant endocrine therapy with a CDK4/6 inhibitor called abemaciclib.

  • 0 views
  • 25 Mar, 2022
  • 23 locations
Adj. Dyn. Marker-adjusted Personalized Therapy Comparing Abemaciclib + SOC ET vs. SOC ET in Clinical or Genomic High Risk HR+/HER2- EBC

early breast cancer benefits from treatment with the medication abemaciclib in combination with ET compared to ET alone.

  • 0 views
  • 03 Sep, 2021
  • 9 locations
Abemaciclib in Patients With Oligodendroglioma

This is a phase II, single arm, open label study looking how well a drug called abemaciclib works in patients with recurrent oligodendroglioma

nitrosoureas
neutrophil count
glomerular filtration rate
MRI
karnofsky performance status
  • 119 views
  • 05 Jun, 2022
  • 1 location
Study Evaluating Abemaciclib + Aromatase Inhibitors in HR+, HER2- Advanced Breast Cancer Patients (HERMIONE-7) (HERMIONE-7)

metastatic disease. Patients will receive aromatase inhibitors plus Abemaciclib.

estrogen
her2-negative breast cancer
progesterone receptor
aromatase inhibitor
measurable disease
  • 39 views
  • 25 Mar, 2022
  • 38 locations
Neoadjuvant Study Chemotherapy vs Letrozole + Abemaciclib in HR+/HER2- High/Intermediate Risk Breast Cancer Patients

Phase II, randomized, open-label, international, multicenter study to compare efficacy of standard chemotherapy vs. letrozole plus abemaciclib as neoadjuvant therapy in HR-positive/HER2-negative

  • 0 views
  • 19 Nov, 2021
  • 28 locations
A Study to Evaluate Abemaciclib in Advanced Biliary Tract Carcinoma Who Failed Prior First Line Therapy

and safety of abemaciclib in patients with late-stage or progressed BTC that has failed one line of chemotherapy.

  • 0 views
  • 25 Mar, 2022
  • 1 location
SARC041: Study of Abemaciclib Versus Placebo in Patients With Advanced Dedifferentiated Liposarcoma

This is a Phase 3 randomized double-blind study of abemaciclib versus placebo. Patients with progression of disease will cross over to open label abemaciclib.

  • 0 views
  • 19 Jun, 2022
  • 5 locations
A Study of Abemaciclib (LY2835219) in Combination With Temozolomide and Irinotecan and Abemaciclib in Combination With Temozolomide in Children and Young Adult Participants With Solid Tumors

The study's purpose is to see if the drug abemaciclib is safe and effective in combination with temozolomide and irinotecan (Part A) and abemaciclib in combination with temozolomide (Part B) in

  • 6 views
  • 27 Jun, 2022
  • 15 locations
Abemaciclib (LY2835219) Plus Fulvestrant Compared to Placebo Plus Fulvestrant in Previously Treated Breast Cancer (postMONARCH)

This study will evaluate the effect of adding abemaciclib to fulvestrant for the treatment of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) breast

aromatase inhibitor
EGFR
erbb2
epidermal growth factor receptor
breast cancer
  • 14 views
  • 15 Jun, 2022
  • 99 locations
A Study of Abiraterone Acetate Plus Prednisone With or Without Abemaciclib (LY2835219) in Participants With Prostate Cancer (CYCLONE 2)

This study is being done to see how safe and effective abemaciclib is when given together with abiraterone acetate plus prednisone in participants with metastatic castration resistant prostate

adenocarcinoma of prostate
prostate cancer metastatic
androgens
progressive disease
abiraterone
  • 537 views
  • 17 Jun, 2022
  • 55 locations