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Found 50 clinical trials
Efficacy, Safety, and Tolerability of ATM-AVI in the Treatment of Serious Infection Due to MBL-producing Gram-negative Bacteria

intra-abdominal infections (cIAI), nosocomial pneumonia (NP) including hospital acquired pneumonia (HAP) and ventilator associated pneumonia (VAP), complicated urinary tract infections (cUTI), or

  • 14 views
  • 12 Aug, 2022
  • 9 locations
Closed or Open Abdomen for the Management of Abdominal Sepsis

This is a prospective randomized clinical study. The study will comprise the randomized decision to either A) primarily close the fascia after laparotomy for intra-abdominal infection (CLOSED

laparotomy
clinical decision making
sepsis
  • 2 views
  • 21 Mar, 2022
  • 1 location
Role of Delay and Antibiotics on Perforation Rate While Waiting Appendectomy

This study evaluates the effects of preoperative delay and antibiotics on perforation rate of appendix while waiting surgery for acute appendicitis. Patients with diagnosed acute appendicitis are randomized into two urgency groups: surgery within 8 hours or surgery within 24 hours. In addition, patients are randomized to either receive antibiotics …

metronidazole
appendectomy
antibiotic therapy
MRI
antibiotics
  • 0 views
  • 04 Sep, 2021
  • 2 locations
Restricted or Liberal Antibiotics After Appendectomy (CASA RELAX)

The purpose of this study is to see if decreasing the amount of antibiotics after appendicitis surgery can decrease the risk of adverse effects associated with antibiotics while at the same time ensuring participant safety.

antibiotics
appendectomy
  • 0 views
  • 25 May, 2022
  • 1 location
ERAS for Pediatric Acute Appendicitis (EPAA)

This multicenter, prospective randomized controlled study is designed to applicate perioperative Enhanced recovery after surgery (ERAS) management for children with acute appendicitis, the aim is to promote postoperative recovery, shorten the hospital length of stay, and reduce the incidence of postoperative complications.

  • 4 views
  • 14 May, 2022
  • 1 location
A Study to Determine the Efficacy, Safety and Tolerability of Aztreonam-Avibactam (ATM-AVI) ± Metronidazole (MTZ) Versus Meropenem (MER) ± Colistin (COL) for the Treatment of Serious Infections Due to Gram Negative Bacteria. (REVISIT)

A Phase 3 comparative study to determine the efficacy, safety and tolerability of Aztreonam-Avibactam (ATM-AVI) ± Metronidazole (MTZ) versus Meropenem (MER) ± Colistin (COL) for the treatment of serious infections due to Gram negative bacteria.

ct scan
metronidazole
colistin
ATM
antibiotic therapy
  • 969 views
  • 10 Aug, 2022
  • 121 locations
Safety, Tolerability, Efficacy and Pharmacokinetics of Imipenem/Cilastatin/Relebactam (MK-7655A) in Pediatric Participants With Gram-negative Bacterial Infection (MK-7655A-021)

infection types: hospital-acquired bacterial pneumonia (HABP) or ventilator-associated bacterial pneumonia (VABP); complicated intra-abdominal infection (cIAI); or complicated urinary tract infection (cUTI

  • 74 views
  • 27 Jul, 2022
  • 39 locations
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of Cefiderocol in Hospitalized Pediatric Participants

The primary objectives of this study are: To assess the safety and tolerability of cefiderocol after single-dose administration in hospitalized paediatric participants 3 months to < 18 years of age with suspected or confirmed aerobic Gram-negative bacterial infections To assess the pharmacokinetics (PK) of cefiderocol after single-dose administration of cefiderocol …

pneumonia
renal function
cefiderocol
sepsis
bacterial infection
  • 7 views
  • 28 Apr, 2022
  • 9 locations
Safety and Effectiveness of Early Feeding After Bowel Anastomosis in Neonates or Infants

The study is primary designed to evaluate the safety and effectiveness of early feeding after bowel anastomosis, and observe the effect of early postoperative feeding on promoting postoperative rehabilitation and reducing parenteral nutrition

  • 0 views
  • 25 Jan, 2021
  • 2 locations
Different Pancreaticojejunostomy After Pancreaticoduodenectomy

The aim of this study was to reduce the incidence of postoperative pancreatic fistula after pancreaticoduodenectomy by using different pancreaticojejunostomy methods according to the position of the pancreatic duct.

  • 0 views
  • 09 Aug, 2022