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Found 38 clinical trials
A Study to Evaluate Efficacy and Safety of Abatacept in Participants of Pemphigus Vulgaris (PV)

Pemphigus vulgaris (PV) is a rare, chronic, debilitating, and potentially life-threatening autoimmune disorder that is characterized by mucocutaneous blisters.Abatacept is a biologic drug that belongs to the class of T-cell co-stimulation modulators and is used for the treatment of autoimmune diseases.

biologics
immunoglobulin g
prednisone
follicle stimulating hormone
  • 0 views
  • 23 Apr, 2022
  • 1 location
The Immunogenicity and Safety of Zostavax® and Shingrix® in Rheumatoid Arthritis Patients Using Abatacept (BMS-188667)

. Inclusion/exclusion criteria for this sub-study mirror that of the parent VERVE trial with the exception of abatacept therapy being allowed. Preliminary data from the VERVE parent protocol enrolling

shingrix
tumor necrosis factor
abatacept therapy
zostavax
abatacept
  • 157 views
  • 15 Jun, 2022
  • 4 locations
Safety and Efficacy of Abatacept for Treating Chronic Cytopenia in Cytotoxic T-Lymphocyte Antigen 4 (CTLA4) Haploinsufficiency

want to see if the drug abatacept can treat cytopenias by replacing the missing protein CTLA4. Objective To see if abatacept is safe and helps

  • 2 views
  • 10 Aug, 2022
  • 1 location
Comparing Cyclophosphamide and Abatacept With Standard of Care Treatment Following Stem Cell Transplantation in Patients With Hematologic Malignancy

The purpose of this study is to investigate whether the combination of cyclophosphamide and abatacept versus the treatment used in standard of care will reduce the incidence of moderate and

cyclophosphamide
lymphoma
cell transplantation
graft versus host disease
hodgkin's disease
  • 5 views
  • 08 Apr, 2022
  • 1 location
Preventing Extension of Oligoarticular Juvenile Idiopathic Arthritis JIA (Limit-JIA) (Limit-JIA)

This is a research study to test whether a once-weekly injection of abatacept will prevent the progression of Juvenile Idiopathic Arthritis (JIA) to a more severe form.To evaluate the

biologics
abatacept
uveitis
DMARD
polyarthritis
  • 2 views
  • 19 Feb, 2022
  • 13 locations
High-Dose Post-Transplant Cyclophosphamide, Bortezomib and Abatacept for the Prevention of Graft-versus-Host-Disease (GvHD) Following Allogenic Hematopoietic Stem Cell Transplantation (HSCT) Study

a standard of care conditioning regimen. Subjects will receive investigational PTCy, investigational bortezomib and investigational abatacept as GvHD prophylaxis.

  • 0 views
  • 25 Apr, 2022
  • 1 location
Early Markers of Disease and Response to Therapy

The purpose of this study is to identify early immune markers associated with response to treatment with abatacept in individuals with Type 1 diabetes (T1D). In this open label mechanistic study

  • 18 views
  • 07 May, 2021
  • 2 locations
Acute GVHD Suppression Using Costimulation Blockade to Expand Non-malignant Transplant (ASCENT)

patients with serious non-malignant hematologic diseases (NMHD) undergoing unrelated donor (URD) hematopoietic stem cell transplantation (HSCT) with abatacept added to conventional GVHD prophylaxis. The

granulocyte colony stimulating factor
mycophenolate
cell transplantation
blood disorder
tacrolimus
  • 4 views
  • 04 Feb, 2022
  • 6 locations
Usefulness of Non TNF Usage in RA Patients

>Tocilizmab treatment for 12 months Abatacept treatment for 12 months

tumor necrosis factor
abatacept
  • 0 views
  • 30 Sep, 2021
  • 1 location
Biologics for Rheumatoid Arthritis Pain (BIORA-PAIN)

participants with active Rheumatoid Arthritis treated with abatacept and Tumor Necrosis Factor (TNF) inhibitors respectively. All measures will be conducted systematically in the abatacept and TNF inhibitor

cyclic citrullinated peptide antibody
tumor necrosis factor
adalimumab
DMARD
hydroxychloroquine
  • 13 views
  • 26 Jan, 2021
  • 1 location