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Found 36 clinical trials
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Comparing Cyclophosphamide and Abatacept With Standard of Care Treatment Following Stem Cell Transplantation in Patients With Hematologic Malignancy

The purpose of this study is to investigate whether the combination of cyclophosphamide and abatacept versus the treatment used in standard of care will reduce the incidence of moderate and

cyclophosphamide
lymphoma
multiple myeloma
chronic graft versus host disease
cancer
  • 0 views
  • 13 Mar, 2021
  • 1 location
None
Preventing Extension of Oligoarticular Juvenile Idiopathic Arthritis JIA (Limit-JIA)

This is a research study to test whether a once-weekly injection of abatacept will prevent the progression of Juvenile Idiopathic Arthritis (JIA) to a more severe form.To evaluate the

arthritis
polyarthritis
biologics
uveitis
DMARD
  • 0 views
  • 31 May, 2021
  • 13 locations
None
Acute GVHD Suppression Using Costimulation Blockade to Expand Non-malignant Transplant

patients with serious non-malignant hematologic diseases (NMHD) undergoing unrelated donor (URD) hematopoietic stem cell transplantation (HSCT) with abatacept added to conventional GVHD prophylaxis. The

blood disorder
anemia
chronic graft versus host disease
mycophenolate
acute graft-versus-host disease
  • 4 views
  • 19 Oct, 2021
  • 7 locations
None
Early Markers of Disease and Response to Therapy

The purpose of this study is to identify early immune markers associated with response to treatment with abatacept in individuals with Type 1 diabetes (T1D). In this open label mechanistic study

  • 0 views
  • 07 May, 2021
  • 2 locations
None
Usefulness of Non TNF Usage in RA Patients

>Tocilizmab treatment for 12 months Abatacept treatment for 12 months

tumor necrosis factor
abatacept
  • 0 views
  • 30 Sep, 2021
  • 1 location
None
TOLERA: Tolerance Enhancement in RA

(Rituximab) and a T cell targeting therapy (Abatacept) were described to lower anti-CCP2 antibody levels and occasionally trigger disappearance of these autoantibodies (sero conversion). By sequentially

  • 0 views
  • 23 Jan, 2021
  • 1 location
None
Biologics for Rheumatoid Arthritis Pain (BIORA-PAIN)

participants with active Rheumatoid Arthritis treated with abatacept and Tumor Necrosis Factor (TNF) inhibitors respectively. All measures will be conducted systematically in the abatacept and TNF inhibitor

DMARD
sulfasalazine
hydroxychloroquine
tumor necrosis factor alpha
adalimumab
  • 0 views
  • 26 Jan, 2021
  • 1 location
None
Clinical Trial Evaluating Methotrexate + Biologic Versus Methotrexate Salazopyrine and Hydroxychloroquine in Patients With Rheumatoid Arthritis and Insufficient Response to Methotrexate

unclear. Rheumatologists are currently used to adding a targeted biologic therapy, such as anti-TNF, and more recently abatacept or tocilizumab. Triple therapy using 3 conventional disease-modifying drugs

etanercept
golimumab
hydroxychloroquine
rheumatoid factor
adalimumab
  • 0 views
  • 14 Aug, 2021
  • 1 location
None
Using Adalimumab Serum Concentration to Choose a Subsequent Biological DMARD in Rheumatoid Arthritis Patients Failing Adalimumab Treatment

A potential application of therapeutic drug monitoring is to predict efficacy after switch to another biological in the case of inefficacy of the previous TNF-inhibitor (TNFi) in rheumatoid arthritis (RA) patients. It has been shown that when antidrug antibodies against adalimumab are detected (resulting in lower drug serum concentrations) in …

methotrexate
leflunomide
DMARD
adalimumab
tumor necrosis factor
  • 3 views
  • 22 Jun, 2021
  • 2 locations
None
SarS-Cov-2 Viral Infection (COVID-19) in Patients With Chronic Inflammatory Rheumatism

The purpose of this study is to assess whether immunosuppressive therapies used by patients with chronic inflammatory rheumatic diseases have an impact on the viral load and the humoral and cellular responses during viral infection with SarSCoV2, compared to members of their family cluster infected with the same viral strain.

baricitinib
tofacitinib
abatacept
methotrexate
rituximab
  • 0 views
  • 10 May, 2021
  • 1 location