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Found 36 clinical trials
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Effects of Abatacept on Myocarditis in Rheumatoid Arthritis

This study aims to evaluate the effects of abatacept, a CTLA4-Ig fusion protein that binds CD80/86 (B7-1/B7-2), on subclinical myocarditis in rheumatoid arthritis (RA) through its effect on T

abatacept
heart failure
fusion protein
fdg pet/ct
methotrexate
  • 95 views
  • 12 Aug, 2021
  • 1 location
None
Abatacept for the Treatment of Giant Cell Arteritis

This randomized, double-blind, placebo-controlled trial will seek to determine the efficacy of abatacept in GCA. To examine this objective, 62 eligible patients who have newly diagnosed or

  • 0 views
  • 27 Mar, 2021
  • 1 location
None
Abatacept s.c. for aGVHD Prevention in Haplo-HCT

. Abatacept has been demonstrated as a potent drug to reduce the risk of aGVHD, but the efficacy of subcutaneous form has yet been investigated. This trial is designed to preliminarily determin the efficacy

  • 0 views
  • 10 Jun, 2021
  • 1 location
None
Abatacept for the Treatment of Myositis-associated Interstitial Lung Disease

A randomized, controlled pilot trial to evaluate the efficacy and safety of subcutaneous Abatacept in treating interstitial lung disease associated with the anti-synthetase syndrome.

igiv
myositis
prednisone
infliximab
ciclosporin
  • 188 views
  • 18 Apr, 2021
  • 5 locations
None
An Exploratory Study on the Efficacy and Safety of Abatacept in the Treatment of Refractory Dermatomyositis

regimens, which is called refractory dermatomyositis. Abatacept has been approved by the FDA for the treatment of three types of rheumatoid immune diseases, and the international consensus of experts

dermatomyositis
cyclophosphamide
methotrexate
cyclosporine
abatacept
  • 0 views
  • 09 Jul, 2021
  • 1 location
None
Abatacept in Individuals Who aRe Considered At Risk of Developing Inflammatory Arthritis

Phase II, single-centre, open label, two parallel arm cohort randomised controlled trial (RCT) testing abatacept in a population of anti-CCP Ab positive individuals at moderate to high risk of

abatacept
stiffness
  • 74 views
  • 24 Jan, 2021
  • 1 location
None
Abatacept for the Treatment of Common Variable Immunodeficiency With Interstitial Lung Disease

There is no standard of care therapy for patients with granulomatous-lymphocytic interstitial lung disease (GLILD) seen in common variable immunodeficiency (CVID). Abatacept has recently looked

interstitial lung disease
immunodeficiency
immune globulin
serum igg
lung biopsy
  • 0 views
  • 31 Jul, 2021
  • 1 location
None
Abatacept vs Tocilizumab for the Treatment of RA in TNF Alpha Inhibitor Inadequate Responders

. This new biotherapy class includes tocilizumab and abatacept, two drugs recently available for subcutaneous administration that enables ambulatory care for patients who would otherwise require

tumor necrosis factor
tumor necrosis factor inhibitors
roactemra
abatacept
tumor necrosis factor alpha
  • 11 views
  • 22 Jan, 2021
  • 1 location
None
Abatacept Ixazomib Citrate and Dexamethasone in Treating Patients With Multiple Myeloma Resistant to Chemotherapy

This phase II trial studies how well abatacept, ixazomib citrate, and dexamethasone work in treating patients with multiple myeloma that is resistant to chemotherapy. Abatacept may block certain

bortezomib
carfilzomib
proteasome inhibitor
neutrophil count
dexamethasone
  • 4 views
  • 11 Jun, 2021
  • 3 locations
None
The Immunogenicity and Safety of Zostavax in Rheumatoid Arthritis Patients Using Abatacept

. Inclusion/exclusion criteria for this sub-study mirror that of the parent VERVE trial with the exception of abatacept therapy being allowed. Preliminary data from the VERVE parent protocol enrolling

arthritis
shingrix
varicella
abatacept therapy
ovariectomy
  • 151 views
  • 20 Aug, 2021
  • 4 locations