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Found 754 clinical trials
Local Ablative Therapy for Patients With Multiple (4-10) Brain Metastases

To observe the quality of life (QOL) and to report on toxicity and outcome parameters after the (repeated) use of local ablative therapy (LAT) i.e. stereotactic radiotherapy (SRT) for patients with multiple (4-10) brain metastases

  • 28 Oct, 2021
  • 1 location
BRIANSTORM - Early Identification of Patients With Brain Metastases

A single arm observational study investigating the incidence of brain metastasis in patients with cancer recti and lung metastasis

  • 23 Mar, 2022
  • 1 location
PFS and OS of Patients With Advanced Neuroendocrine Cancer (NEN) After Systemic Treatment

This is a retrospective study. The analysis includes patients with advanced neuroendocrine cancer (NEN) treated with systemic therapy, because of inoperable primary tumor or/and metastasis, clinical, imaging, biochemical disease progression and no standard method of treatment hormone overproduction symptoms. The data of patients with advanced NEN with histopathological confirmation is …

  • 24 May, 2021
  • 2 locations
Ultra-high-frequency ECG for Prediction of Left Ventricular Remodeling

The main goal of the project is to prove that ultra-high-frequency ECG (UHF-ECG) can be used as a diagnostic tool that allows the prediction of patients susceptible to the negative effect of right ventricular myocardial pacing. The prediction will be based on the assessment of electrical dyssynchrony and local depolarization …

  • 07 Jun, 2021
  • 1 location
The Use of Lymph Node Biopsies to Support HIV Pathogenesis Studies

HIV medicines have led to dramatic improvements in health. However, there remains a concern for potential drug toxicities, cost of drugs, and need for life-long treatment. In addition, research has found that health is not completely restored in HIV-infected patients, even if they have been taking effective HIV medicines for …

HIV Vaccine
antiretroviral agents
Accepts healthy volunteers
antiretroviral therapy
  • 09 Jun, 2022
  • 1 location
PTGS1 Genetic Variation and Increased Risk for Persistent Pulmonary Hypertension of the Newborn (PPHN)

The purpose of this study is to determine if normally occurring variations in a specific gene called PTGS-1 are associated with an increased risk of narrowing of the ductus arteriosus from exposure to over-the-counter pain medicines (NSAIDs).

Accepts healthy volunteers
  • 23 Mar, 2022
  • 1 location
Prospective Evaluation of Pathways for Preterm Birth (PEPP)

This is a single center, prospective cohort study of pregnant patients at high risk for spontaneous preterm birth: patient's with history of spontaneous preterm birth and patient's with a short cervix from 5-30 mm will be included. A control cohort of nulliparous patients without a short cervix will be recruited …

Accepts healthy volunteers
  • 11 Mar, 2022
  • 1 location
Sickle Cell Hemoglobinopathies and Bone Health

This research study has two purposes. The first purpose is to determine whether having sickle cell trait (SCT) is a risk factor for the development of bone thinning at an earlier age than expected. Nearly 10% of African Americans (AA) carry sickle cell trait and most of them are unaware …

hemoglobin s
Accepts healthy volunteers
sickle cell trait
  • 26 Jan, 2022
  • 1 location
Prospective Database for Prediction of Atrial Fibrillation in Pacemaker and ICD Patients (SAFE-ME)

Atrial fibrillation (AF) is associated with a five-fold increased risk of cerebrovascular stroke. While the risk of stroke in patients with known AF can be calculated via AF stroke prediction risk scores, the prediction of AF occurrence per se in individual patients remains difficult. We will recruit 250 patients with …

vascular disease
electrocardiographic monitoring
diagnostic procedure
  • 25 Feb, 2022
  • 1 location
Eribulin as a Second-line Treatment in Triple-negative Advanced Breast Cancer (HERMIONE-10)

Multicenter, retrospective and prospective, cohort, observational study evaluating the clinical efficacy and tolerability of Eribulin as second-line treatment in accordance with the indications authorized by AIFA in patients with triple negative advanced breast cancer in a real world setting.

advanced breast cancer
  • 07 Apr, 2022
  • 1 location