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Found 750 clinical trials
Study of VIB7734 for the Treatment of Moderate to Severely Active SLE (RECAST SLE)

A Phase 2 Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of VIB7734 for the Treatment of Moderate to Severely Active Systemic Lupus Erythematosus in approximately 195 participants. The study duration will be 48 weeks, with a safety follow-up through week 56.There will be 3 parallel arms - 2 active treatment …

  • 18 Apr, 2022
  • 70 locations
RESPONSE: Response to Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and an Inadequate Control to or an Intolerance to Ursodeoxycholic Acid (UDCA)

To evaluate the treatment effect of seladelpar on composite biochemical improvement in cholestasis markers based on ALP and total bilirubin and to evaluate the safety of seladelpar over 12 months of treatment compared to placebo

  • 13 Jun, 2022
  • 150 locations
Eptinezumab in Participants With Episodic Cluster Headache (ALLEVIATE)

The purpose of this study is to evaluate the efficacy of eptinezumab in participants with episodic Cluster Headache (eCH)

  • 15 May, 2022
  • 74 locations
Efficacy and Safety of M281 in Adults With Warm Autoimmune Hemolytic Anemia

The main purpose of this study is to evaluate the efficacy and safety of M281 in participants with warm autoimmune hemolytic anemia (wAIHA).

  • 14 Jun, 2022
  • 74 locations
A Study Evaluating the Efficacy and Safety of Mosunetuzumab in Combination With Lenalidomide in Comparison to Rituximab in Combination With Lenalidomide in Patients With Follicular Lymphoma After at Least One Line of Systemic Therapy (Celestimo)

This study will evaluate the efficacy and safety of mosunetuzumab in combination with lenalidomide (M + Len) compared to rituximab in combination with lenalidomide (R + Len) in participants with relapsed or refractory (R/R) follicular lymphoma (FL) who have received at least one line of prior systemic therapy.

  • 16 Jun, 2022
  • 85 locations
Use of Customized GROW Charts for Detection of SGA in Low Risk Woman.

A prospective randomised control trial to evaluate the effectiveness of customised growth charts for detection of small for gestational age fetus in low risk women, in comparison to conventional standard of care.

  • 02 Mar, 2021
  • 1 location
Securing Employment and Economic Keys to Stability for Persons With Disabilities (SEEKS)

There is a myth that if a person is applying for SSI/SSDI he cannot seek employment. This goal of this research is to learn if a new model of service can lead to employment, increase in gross wages, and a decrease in social isolation for persons with disabilities who work …

Accepts healthy volunteers
  • 15 May, 2022
A Long-term Study of Nemolizumab (CD14152) in Participants With Prurigo Nodularis (PN)

The primary purpose of this study is to assess the long-term safety of nemolizumab (CD14152) in participants with prurigo nodularis (PN).

  • 04 Jun, 2022
  • 83 locations
A Phase II Randomized Study Comparing the Efficacy and Safety of Targeted Therapy or Cancer Immunotherapy Versus Platinum-Based Chemotherapy in Patients With Cancer of Unknown Primary Site (CUPISCO)

This study will compare the efficacy and safety of molecularly-guided therapy versus standard platinum-containing chemotherapy in participants with poor-prognosis cancer of unknown primary site (CUP; non-specific subset) who have achieved disease control after 3 cycles of first-line platinum based induction chemotherapy.

  • 18 Jun, 2022
  • 112 locations
Seamless Controlled Trial To Evaluate Safety And Immunogenicity of Chikungunya Vaccine in LatinAmerica and Asia (IVICHIK001)

This study has a Phase II with part A and part B and a Phase III with part C. This Adaptive seamless design will prospectively include planned modifications and incorporate both dose selection (parts A and B) and confirmation of the selected dose (part C) based on the accumulation of …

Accepts healthy volunteers
  • 07 Apr, 2022
  • 6 locations