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Found 42 clinical trials
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A long-term 4+ year, double blind placebo controlled study to evaluate the effects of bexagliflozin on hemoglobin A1c in patients with type 2 diabetes and increased risk of cardiovascular adverse events

A long-term 4+ year, double blind placebo controlled study to evaluate the effects of bexagliflozin on hemoglobin A1c in patients with type 2 diabetes and increased risk of cardiovascular adverse events

  • 273 views
  • 08 Nov, 2020
  • 1 location
None
The Oral Iron on the Prevention of Iron Deficiency Anemia in Obese Pregnant

Anemia is known as a condition in which the hemoglobin level is lower than normal. Anemia is one of the most common complications during pregnancy. Anemia in pregnancy is defined as a hemoglobin

  • 0 views
  • 01 Nov, 2021
  • 1 location
None
Role of Blood Management in Perioperative Outcomes

There is currently limited information regarding the role of blood management in the benign gynecologic population and specifically, in patients who are scheduled to undergo surgery for fibroids and/or abnormal uterine bleeding. A thorough search through PubMed and clinicaltrials.gov did not reveal any studies on this issue. In 2019 at …

  • 0 views
  • 22 Aug, 2021
  • 1 location
None
CytoSorb Reduction of FREee Hemoglobin/Acute Kidney Injury (AKI) During Cardiac Surgery

Prospective, multi-center, randomized, blinded, pivotal clinical study. Subjects will be randomized in a 1:1 ratio to either standard of care (SOC) alone or standard of care plus treatment with the CytoSorb device.

  • 20 views
  • 09 Apr, 2021
  • 25 locations
None
A Monocentric Study Assessing the Efficacy of the Nitrosylated Hemoglobin as Biomarker for Detecting the Development of a Cardiovascular Complication During or After Surgery

Cardiovascular diseases are the first mortality cause in Occidental countries. Surgery and anesthesia can provoke hemodynamic instability and stimulation of the sympathetic nervous system as well as bleeding or thrombosis. These factors as top of some post-operative factors such as tissular hypoxemia, can result in cardiovascular complications. Developing a tool …

cardiovascular disease
diabetes
  • 0 views
  • 06 Oct, 2021
  • 1 location
None
Study of Safety & PK of Luspatercept (ACE-536) in Pediatric Participants Who Require Regular RBC Transfusions Due to Beta ( )-Thalassemia.

This is a Phase 2a study to evaluate the safety and pharmacokinetics (PK) of luspatercept in pediatric participants who require regular red blood cell transfusions due to -thalassemia. The study will be conducted in 2 parts: Part A will be in adolescent participants aged 12 to <18 years with two …

hysterectomy
progesterone
ace-536
luspatercept
hemoglobin e
  • 6 views
  • 18 Jun, 2021
  • 8 locations
None
HEMOglobin Transfusion Threshold in Traumatic Brain Injury OptimizatioN: The HEMOTION Trial

Most trauma deaths are related to traumatic brain injury (TBI). Although the management of patients has improved, mortality remains unacceptably high, and half of survivors of moderate and severe TBI are left with major functional impairment. Current management guidelines are based on limited evidence and practice is highly variable. Most …

coma
traumatic brain injury
  • 757 views
  • 25 Jan, 2021
  • 24 locations
None
A Study to Evaluate GBT021601 in Single and Multiple Doses in Healthy Participants

This first in human study is designed to evaluate the safety, tolerability, pharmacokinetics (PK), and food effect of GBT021601, a hemoglobin S (HbS) polymerization inhibitor, in healthy

body mass index
sickle hemoglobin
hemoglobin s
  • 0 views
  • 12 Sep, 2021
  • 2 locations
None
A Study to Evaluate GBT021601-012 Single Dose and Multiple Dose in Participants With Sickle Cell Disease (SCD)

GBT021601, a hemoglobin S (HbS) polymerization inhibitor, in participants with SCD, following single and multiple ascending doses.

sickle hemoglobin
hemoglobin s
  • 0 views
  • 03 Jan, 2022
  • 1 location
None
Time Limited Eating in Adolescents With Type 2 Diabetes

). One-hundred adolescents with T2D (aged 14-21 years), diagnosed within the last 6 months, with a hemoglobin A1c < 9%, and on Metformin monotherapy, will be recruited from Children's Hospital Los

fats
hemoglobin a1c
sugars
fasting
a 12
  • 0 views
  • 05 Aug, 2021
  • 1 location