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Found 92 clinical trials
CAP-100 for Subjects With Relapsed/Refractory Chronic Lymphocytic Leukemia

therapies (e.g. ibrutinib, acalabrutinib) or combined immuno-chemotherapy regimens (e.g., fludarabine, cyclophosphamide, and rituximab for patients aged <65 years without del17p/TP53 mutations or

bendamustine
acalabrutinib
TP53
chronic lymphocytic leukemia
rituximab
  • 0 views
  • 01 Oct, 2021
  • 2 locations
The Culture of Ovarian Cancer Organoids and Drug Screening

The tumor organoids platform can provide the precise genetic information and phenotype, as well as the heterogeneity of the tumor, thus provide information on drug sensitivity specific to the patient.This is an exploratory research to see if organoids testing could help guide precision treatment for ovarian cancer(OC) patients.

cytoreductive surgery
cancer of the ovary
carcinoma
  • 0 views
  • 09 May, 2022
  • 1 location
Determine the Utility of Liquid Biopsies and Tumor Molecular Profiling in Predicting Recurrence in High-Risk Endometrial Cancers

This study is to find out how well liquid biopsies work as a non-invasive alternative to other methods of finding cancer cells (such as a tissue biopsy) in patients with high-risk endometrial cancer. A liquid biopsy is a blood test that may be able to find cancer cells. Collecting and …

carcinosarcoma
  • 0 views
  • 26 Sep, 2021
  • 1 location
Next Generation Sequencing (NGS) in Familial Acute Myeloid Leukemia and Myelodisplastic Syndromes

The aim of this study is to look for predisposing mutations in patients and relatives affected by AML and MDS with familial history of myeloid or, less frequently, lymphoid malignancies. Taking advantage of a next generation sequencing (NGS) platform, screening for known and unknown mutations potentially associated with the disease …

acute leukemia
myeloid leukemia
cancer
thrombocytopenia
  • 3 views
  • 01 May, 2022
  • 1 location
Developing a Test for the Detection of Ovarian Cancer

The study aims to develop a test for early detection of ovarian cancer using DNA from a growth involving the ovary found in a washing of the uterus (womb), and proteins found in the blood. The samples of the wash and the blood will be taken before surgery. After surgery, …

BRCA2
cancer of the ovary
fallopian tube
BRCA1
cavity
  • 0 views
  • 10 May, 2022
  • 4 locations
Men at High Genetic Risk for Prostate Cancer

Background Research studies have shown that genetic changes and family history may increase a man s risk for prostate cancer. Researchers want to follow the prostate health of men who have specific genetic changes associated with prostate cancer to help them learn more about which men are at higher risk …

testosterone
blood test
cancer
MRI
  • 109 views
  • 17 Jun, 2022
  • 1 location
Collecting and Storing Tissue From Young Patients With Cancer

This laboratory study is collecting and storing tissue, blood, and bone marrow samples from young patients with cancer. Collecting and storing samples of tissue, blood, and bone marrow from patients with cancer to study in the laboratory may help doctors learn more about changes that may occur in DNA and …

primary cancer
cancer
ewing sarcoma family of tumors
germ cell tumors
ewing sarcoma/peripheral primitive neuroectodermal tumor
  • 33 views
  • 14 Mar, 2022
  • 24 locations
NGS in Gallbladder Cancer and Response to Treatment

Evidence suggests distinct models of molecular and pathologic progression, and a growing body of genetics data points to a heterogeneous collection of underlying mutations in key oncogenes and tumor suppressor genes. Although tumor genetics have been used to tailor individual treatment regimens and guide clinical decision making in other cancers, …

  • 0 views
  • 18 Jun, 2022
  • 1 location
Circulating Tumor DNA as Marker for Response to Antineoplastic Treatment of Metastatic Cancer (FLUIDO)

Early monitoring of antineoplastic treatment benefit is a central medical need. Radiologic assessment for documentation of response is done after several months of treatment usually. This implies that patients not responding are exposed to unnecessary toxicity. According to several reports showing the correlation of the amount of circulating tumour DNA …

  • 0 views
  • 18 Mar, 2021
  • 1 location
The circTeloDIAG: Liquid Biopsy for Glioma Tumor

Gliomas represent the most frequent primary brain tumor, with 2,500 to 3,000 new cases per year in France. Their diagnosis, although highly complex, is essential for determining patient management. While grade I gliomas (infrequent) are curable by surgery or present a slow progression, grades II to IV require heavy treatment …

primary brain tumors
recurrent glioma
brain tumor
  • 0 views
  • 17 Aug, 2021
  • 1 location