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Found 87 clinical trials
Clinical and Genetic Studies of Li-Fraumeni Syndrome

tissue, breast, and brain. It may also increase the risk for certain types of leukemia and other cancers. The only known cause of LFS is a change (called a mutation ) in a gene known as TP53. However

carcinoma
primary cancer
cancer screening
leukemia
Accepts healthy volunteers
  • 1 views
  • 28 Jul, 2022
  • 2 locations
Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

Background Researchers are interested in studying individuals who have known or suspected metabolic or genetic diseases that put them at a high risk for heart diseases or diseases of their blood vessels. To improve the results of the study, both affected and nonaffected individuals will be asked to provide blood …

cardiovascular disease
walk test
angiography
ct scan
heart disease
  • 167 views
  • 03 Jun, 2022
  • 1 location
Homologous Recombination Deficiency Status in Epithelial Ovarian Cancer

, TP53, CDH1. The study would select 150 patients with pathogenic or likely pathogenic mutations in BRCA1/2 and 150 patients without these mutations to further explore the HRD status. The HRD model is

BAP1
MRE11A
CHEK1
CDH1
homologous recombination deficiency
  • 0 views
  • 21 Feb, 2022
  • 1 location
Hereditary Gastric Cancer Syndromes: An Integrated Genomic and Clinicopathologic Study of the Predisposition to Gastric Cancer

Background Gastric cancers are cancers of the stomach. Hereditary ones are passed from parent to child. Researchers want to gather data about hereditary gastric cancers. They want to learn about changes these cause in the body and about the genes involved. Objective -To gather data about hereditary gastric cancer. Eligibility …

gastric neoplasm
CDH1
gastric cancer
Accepts healthy volunteers
adenocarcinoma
  • 214 views
  • 29 Jul, 2022
  • 1 location
Familial Investigations of Childhood Cancer Predisposition (SJFAMILY)

NOTE: This is a research study and is not meant to be a substitute for clinical genetic testing. Families may never receive results from the study or may receive results many years from the time they enroll. If you are interested in clinical testing please consider seeing a local genetic …

familial cancer
childhood cancer
biological factors
cancer
genetic testing
  • 223 views
  • 25 May, 2022
  • 1 location
Prospective Study of MAstectomy With Reconstruction Including Robot Endoscopic Surgery

Robotic mastectomy and immediate reconstruction have been introduced recently in 2015. However, since robotic mastectomy is latest surgical technique, there is a lack of studies comparing conventional mastectomy and immediate reconstruction with robotic mastectomy prospectively. For this reason, this study is designed to establish a single institution cohort study that …

BRCA1/2
mastectomy
BRCA1
TP53
palb2
  • 0 views
  • 20 Jun, 2021
  • 1 location
Personalized Medicine Program on Myelodysplastic Syndromes: Characterization of the Patient's Genome for Clinical Decision Making and Systematic Collection of Real World Data to Improve Quality of Health Care

BACKGROUND Myelodysplastic syndromes (MDS) typically occur in elderly people and with time, a portion of the patients evolve into acute myeloid leukemia (AML). Therefore a risk-adapted treatment strategy is mandatory. Current prognostic scores present limitations, and in most cases fail to capture reliable prognostic information at individual level. STATE OF …

  • 0 views
  • 05 Mar, 2021
  • 1 location
Long Term Follow-up of Mesothelioma Patients and Their Family Members With Germline Mutations in BAP1 and Other Genes

Background -A gene provides instructions to the body. Mutated genes can sometimes cause cancer. Germline mutations are those people are born with. These mutations in the BAP1 gene can cause mesothelioma and other cancers. Researchers want to study people with germline mutations of BAP1 and other genes known to cause …

BAP1
cancer
skin lesions
blood test
  • 5 views
  • 21 Jul, 2022
  • 1 location
Circulating Tumor DNA Analysis to Optimize Treatment for Patients With Colorectal Cancer (IMPROVE)

The overall objective of these studies are to confirm that ctDNA detected in plasma after intended curative treatment for CRC can be applied in clinical practice as a marker of subclinical residual disease and risk of recurrence.

rectal carcinoma
  • 18 views
  • 10 Jul, 2022
  • 10 locations
Li-Fraumeni Syndrome/TP53 Biobank

Li-Fraumeni Syndrome (LFS) and Li-Fraumeni-like (LFL) Syndrome are cancer predisposition syndromes due to germline aberrations in the TP53 gene. Patients with classical LFS have a lifetime

Accepts healthy volunteers
  • 0 views
  • 24 Mar, 2022
  • 2 locations