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Found 91 clinical trials
P53MVA and Pembrolizumab in Treating Patients With Recurrent Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

This phase II trial studies how well modified vaccinia virus ankara vaccine expressing p53 (p53MVA) and pembrolizumab work in treating patients with ovarian, primary peritoneal, or fallopian tube cancer that has come back (recurrent). Vaccines made from a gene-modified virus may help the body build an effective immune response to …

  • 20 views
  • 12 Mar, 2022
  • 1 location
Study to Investigate the Use of Acalabrutinib in the Treatment of Patients With Chronic Lymphocytic Leukemia

and aggressive outcome (i.e., TP53). Against this background, it is of interest to investigate the role of new non-genotoxic drugs in the treatment of patients with CLL in early stages. Among

  • 0 views
  • 24 Mar, 2022
  • 14 locations
Sodium Stibogluconate in the MDS/AML With One of the 65 Defined p53 Mutations

To evaluate the safety and effectiveness of Sodium Stibogluconate in the treatment of myelodysplastic syndrome/acute myeloid leukemia (MDS/AML) with p53 mutation from a defined list. The list includes 65 p53 mutations that were experimentally confirmed to be pharmacologically restored with tumor-suppressive function by antimonials.

leukemia
myeloid leukemia
  • 0 views
  • 18 Jun, 2021
  • 1 location
Prognostic Value of Circulating Tumoral DNA After the First 6 Months of Treatment in Patients With Waldenstr m Macroglobulinemia

CXCL12, it is also associated with activations of ERK/MAPK and PI3K). Abnormalities of some of genes, such as TP53, of the expression of the protein CXCL13 and genes involved in the interleukin 6

cytopenia
monoclonal protein
monoclonal antibodies
bone marrow procedure
immunoglobulin
  • 0 views
  • 29 May, 2021
  • 1 location
Lavage of the Uterine Cavity for Diagnosis of Ovarian Cancer

while the woman is under anesthesia for planned debulking surgery. A novel, highly sensitive and accurate technique, Crispr-Duplex sequencing, will be used to detect tumor associated mutations in TP53

TP53
ovarian cancer
tumor debulking
  • 0 views
  • 19 Sep, 2021
  • 1 location
Clinical Research for Azacitidine Combined With Low-dose Dasatinib in Maintenance Therapy of Acute Myeloid Leukemia

mRNA expressions of DNA methyltransferase (DNMT1, DNMT3a, DNMT3b), tumor suppressor genes (TP53, P15, P16, P21, CDH1, DOK6, SHP1, PTPN11) and differentiation genes (pu.1, C/EBP α, C/EBP β) were

minimal residual disease
TP53
azacitidine
flow cytometry
consolidation therapy
  • 1 views
  • 14 May, 2022
  • 1 location
Acalabrutinib and Rituximab in Elderly Patients With Untreated Mantle Cell Lymphoma (ALTAMIRA)

. Patients who convert back to MRD positive after stopping acalabrutinib are reinstalled on acalabrutinib until progression. Patients with TP53 aberrations and/or blastoid histology, will

mantle cell lymphoma
lenalidomide
bendamustine
rituximab
acalabrutinib
  • 0 views
  • 21 Mar, 2022
Venetoclax and Decitabine in Treating Participants With Relapsed/Refractory Acute Myeloid Leukemia or Relapsed High-Risk Myelodysplastic Syndrome

This phase II trial studies how well venetoclax and decitabine work in treating participants with acute myeloid leukemia that has come back or does not respond to treatment, or with high-risk myelodysplastic syndrome that has come back. Drugs used in chemotherapy, such as venetoclax and decitabine, work in different ways …

blast cells
myeloid leukemia
decitabine
complex karyotype
leukemia
  • 54 views
  • 02 May, 2022
  • 1 location
Copanlisib and Nivolumab in Treating Patients With Richter's Transformation or Transformed Indolent Non-Hodgkin Lymphoma

This phase I trial studies the best dose and how well copanlisib when given together with nivolumab works in treating patients with Richter's transformation or transformed indolent non-Hodgkin lymphoma. Copanlisib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal …

tumor cells
monoclonal protein
rituximab
diffuse large b-cell lymphoma
direct bilirubin
  • 17 views
  • 09 Apr, 2022
  • 2 locations
Atezolizumab, Obinutuzumab, and Venetoclax in Treating Patients With Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or Relapsed or Refractory Richter Syndrome

This phase II trial studies how well atezolizumab, obinutuzumab, and venetoclax work in treating patients with chronic lymphocytic leukemia or small lymphocytic lymphoma or Richter syndrome that has come back (recurrent) or does not respond to treatment (refractory). Immunotherapy with monoclonal antibodies, such as atezolizumab and obinutuzumab, may help the …

cancer
monoclonal protein
beta human chorionic gonadotrophin
gilbert's syndrome
venetoclax
  • 0 views
  • 27 Jan, 2022
  • 1 location