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Found 17 clinical trials
Efficacy and Safety of LY01011 and Xgeva in Patients With Bone Metastases From Solid Tumors

This is a multicenterrandomized, double-blind, active-controlled, parallel-group study comparing efficacy and safety of LY01011 (recombinant anti-RANKL human monoclonal antibody injection) and

  • 12 views
  • 16 Jun, 2021
  • 1 location
Breast Cancer Toxicity (CANTO)

The aims of the cohort will be to quantify impact of cancer treatments toxicities , and to generate predictors of chronic toxicity in patients with non-metastatic breast cancer. The project will include four specific aims : To develop a database of chronic treatment related toxicity in a cohort of 14750 …

Accepts healthy volunteers
  • 0 views
  • 19 Apr, 2022
  • 1 location
RANKL Inhibition and Mammographic Breast Density (TRIDENT)

Data supporting a role for RANKL signaling in mammographic density and breast cancer development has begun to emerge, but clinical trial data providing definitive evidence that would allow the

  • 0 views
  • 23 Apr, 2022
  • 1 location
Clinical and Biochemical Evaluation of the Efficacy of Non-Surgical Treatment Approaches in the Treatment of Peri-implantitis

mechanical debridement with titanium curettes. In our study, we aimed to compare these two treatments biochemically by determining the changes in interleukin-1β, Interleukin-10, Interleukin-17, RANKL

Accepts healthy volunteers
  • 0 views
  • 14 Mar, 2022
  • 1 location
FITMI - First In Treating Male Infertility

This RCT aims to assess whether treatment with Denosumab can improve semen quality in infertile men selected by serum AMH as a positive predictive biomarker.

  • 0 views
  • 21 Mar, 2022
  • 1 location
Impact of the Rapid Normalization of Chronic Hyperglycemia and the Practice of Moderate Physical Activity on the "Receptor Activator of Nuclear Factor-kappa B Ligand / Osteoprotégérine (RANKL / OPG) System in Patients Living With Type II Diabetes (RANKL-GLYC)

The rapid normalization of hyperglycemia can cause a neuropathy called Diabetes Treatment-Induced Neuropathy (NITD). This phenomenon induces the presence of hyper vascularization and inflammation in contact with the nerve ends. In another register in patients living with diabetes, it has been observed the development of a rare and devastating complication …

  • 0 views
  • 27 May, 2022
  • 1 location
Effects of Denosumab on Bone Fusion in Osteoporotic Patients After Lumbar Fusion

reason for spinal fusion failure, implant fixation failure, and vertebral compression fractures above or below the fusion sites. Denosumab is a human monoclonal antibody against RANKL, it inhibits

x-rays
calcium
denosumab
x-ray absorptiometry
dual-energy x-ray absorptiometry
  • 0 views
  • 22 Mar, 2022
  • 1 location
Denosumab In Ebv Nasopharyngeal Carcinoma As A Model For RankMediated Immunologic Modulation Of Virus-Related Tumours (Dern)

The aim of the present investigation is to test of the modulation obtained with denosumab as "priming" therapy before the start of chemotherapy and as concurrent therapy in a population of first line NPC recurrent/metastatic patients

cancer
gemcitabine
carcinoma
neutrophil count
epstein-barr virus deoxyribonucleic acid
  • 1 views
  • 27 Feb, 2022
  • 1 location
Denosumab to Prevent High-Turnover Bone Loss After Bariatric Surgery

Bariatric surgery leads to bone loss and increases fracture risk. This study evaluates whether denosumab can prevent the high-turnover bone loss that occurs after Roux-en-Y Gastric Bypass (RYGB) and sleeve gastrectomy (SG) surgery.

roux-en-y
denosumab
gastric bypass
gastrectomy
zoledronic acid
  • 1 views
  • 27 Apr, 2022
  • 1 location
Denosumab and Nivolumab Combination as 2d-line Therapy in Stage IV NSC Lung Cancer With Bone Metastases (DENIVOS)

Bone metastases are common in Non-Small Cell Lung Cancer (NSCLC). They most often occur during disease progression. It is thought that more than half of the patients with bone metastases will have at least 1 skeletal-related event (SRE, i.e. pathological fractures, medullary compression, analgesic radiotherapy, preventive and/or analgesic surgery and …

cancer
x-rays
growth factor
bisphosphonate
renal function
  • 102 views
  • 18 Nov, 2021
  • 44 locations